RT Journal
A1 Tomppo L, Hennah W, Miettunen J, et al
T1 ASsociation of variants in disc1 with psychosis-related traits in a large population cohort
JF Archives of General Psychiatry
JO Archives of General Psychiatry
YR 2009
FD February 1
VO 66
IS 2
SP 134
OP 141
DO 10.1001/archgenpsychiatry.2008.524
UL http://dx.doi.org/10.1001/archgenpsychiatry.2008.524
AB Context 
    There is an abundance of data from human genetic studies and animal models that implies a role for the disrupted in schizophrenia 1 gene (DISC1) in the etiology of schizophrenia and other major mental illnesses.Objective 
    To study the effect of previously identified risk alleles of DISC1 on quantitative intermediate phenotypes for psychosis in an unselected population.Design 
    We examined 41 single-nucleotide polymorphisms within DISC1 and performed tests of association with 4 quantitative phenotypes.Setting 
    Academic research.Participants 
    Individuals from an unselected birth cohort in Finland. Originally, everyone born in the catchment area in 1966 (N = 12 058) was included in the study. Of these, 4651 (38.6%) attended the 31-year follow-up and could be included in the study.Main Outcome Measures 
    Scores on 4 psychometric instruments selected to function as proxies for positive and negative aspects of psychotic disorders, including the Perceptual Aberration Scale, Revised Social Anhedonia Scale, Revised Physical Anhedonia Scale, and Schizoidia Scale by Golden and Meehl.Results 
    Carriers of the minor allele of marker rs821577 had significantly higher scores on social anhedonia (P < .001). The minor allele of marker rs821633 was strongly associated with lower scores on social anhedonia when analyzed dependent on the absence of the minor alleles of markers rs1538979 and rs821577 (P < .001).Conclusions 
    Variants in DISC1 affect the level of social anhedonia, a cardinal symptom of schizophrenia in the general population. DISC1 might be more central to human psychological functioning than previously thought, as it seems to affect the degree to which people enjoy social interactions.