RT Journal
A1 Lock J, Le Grange D, Agras W, Moye A, Bryson SW, Jo B
T1 RAndomized clinical trial comparing family-based treatment with adolescent-focused individual therapy for adolescents with anorexia nervosa
JF Archives of General Psychiatry
JO Archives of General Psychiatry
YR 2010
FD October 4
VO 67
IS 10
SP 1025
OP 1032
DO 10.1001/archgenpsychiatry.2010.128
UL http://dx.doi.org/10.1001/archgenpsychiatry.2010.128
AB Context 
    Evidence-based treatment trials for adolescents with anorexia nervosa are few.Objective 
    To evaluate the relative efficacy of family-based treatment (FBT) and adolescent-focused individual therapy (AFT) for adolescents with anorexia nervosa in full remission.Design 
    Randomized controlled trial.Setting 
    Stanford University and The University of Chicago (April 2005 until March 2009).Participants 
    One hundred twenty-one participants, aged 12 through 18 years, with DSM-IV diagnosis of anorexia nervosa excluding the amenorrhea requirement.Intervention 
    Twenty-four outpatient hours of treatment over 12 months of FBT or AFT. Participants were assessed at baseline, end of treatment (EOT), and 6 months' and 12 months' follow-up posttreatment.Main Outcome Measures 
    Full remission from anorexia nervosa defined as normal weight (≥95% of expected for sex, age, and height) and mean global Eating Disorder Examination score within 1 SD of published means. Secondary outcome measures included partial remission rates (>85% of expected weight for height plus those who were in full remission) and changes in body mass index percentile and eating-related psychopathology.Results 
    There were no differences in full remission between treatments at EOT. However, at both the 6- and 12-month follow-up, FBT was significantly superior to AFT on this measure. Family-based treatment was significantly superior for partial remission at EOT but not at follow-up. In addition, body mass index percentile at EOT was significantly superior for FBT, but this effect was not found at follow-up. Participants in FBT also had greater changes in Eating Disorder Examination score at EOT than those in AFT, but there were no differences at follow-up.Conclusion 
    Although both treatments led to considerable improvement and were similarly effective in producing full remission at EOT, FBT was more effective in facilitating full remission at both follow-up points.Trial Registration 
    clinicaltrials.gov Identifier: NCT00149786