RT Journal A1 Grob CS, Danforth AL, Chopra GS, et al T1 PIlot study of psilocybin treatment for anxiety in patients with advanced-stage cancer JF Archives of General Psychiatry JO Archives of General Psychiatry YR 2011 FD January 3 VO 68 IS 1 SP 71 OP 78 DO 10.1001/archgenpsychiatry.2010.116 UL http://dx.doi.org/10.1001/archgenpsychiatry.2010.116 AB In recent years, there has been a growing awareness that the psychological, spiritual, and existential crises often encountered by patients with cancer and their families need to be addressed more vigorously.1- 4 From the late 1950s to the early 1970s, research was carried out exploring the use of hallucinogens to treat the existential anxiety, despair, and isolation often associated with advanced-stage cancer.5- 15 Those studies described critically ill individuals undergoing psychospiritual epiphanies, often with powerful and sustained improvement in mood and anxiety as well as diminished need for narcotic pain medication. Despite these promising results, there has been no follow-up research.