RT Journal
A1 Lahey BB, Van Hulle CA, Singh AL, Waldman ID, Rathouz PJ
T1 HIgher-order genetic and environmental structure of prevalent forms of child and adolescent psychopathology
JF Archives of General Psychiatry
JO Archives of General Psychiatry
YR 2011
FD February 7
VO 68
IS 2
SP 181
OP 189
DO 10.1001/archgenpsychiatry.2010.192
UL http://dx.doi.org/10.1001/archgenpsychiatry.2010.192
AB Context 
    It is necessary to understand the etiologic structure of child and adolescent psychopathology to advance theory and guide future research.Objective 
    To test alternative models of the higher-order structure of etiologic effects on 11 dimensions of child and adolescent psychopathology using confirmatory factor analyses of genetic and environmental covariances.Design 
    Representative sample of twins.Setting 
    Home interviews.Participants 
    A total of 1571 pairs of 9- to 17-year-old twins.Main Outcome Measures 
    Structured assessments of psychopathology using adult caregivers and youth as informants.Results 
    The best-fitting genetic model revealed that most genetic factors nonspecifically influence risk for either all 11 symptom dimensions or for dimensions of psychopathology within 1 of 2 broad domains. With some notable exceptions, dimension-specific genetic influences accounted for modest amounts of variance.Conclusions 
    To inform theory and guide molecular genetic studies, an etiologic model is offered in which 3 patterns of pleiotropy are hypothesized to be the principal modes of genetic risk transmission for common forms of child and adolescent psychopathology. Some common environmental influences were found, but consistent with a “generalist genes, specialist environments” model, there was little sharing of environmental influences. This implies that prevalent dimensions of child and adolescent psychopathology mostly share their genetic liabilities but are differentiated by nonshared experiences.