RT Journal
A1 O’Daly O, Joyce D, Stephan K, Murray R, Shergill SS
T1 FUnctional magnetic resonance imaging investigation of the amphetamine sensitization model of schizophrenia in healthy male volunteers
JF Archives of General Psychiatry
JO Archives of General Psychiatry
YR 2011
FD June 6
VO 68
IS 6
SP 545
OP 554
DO 10.1001/archgenpsychiatry.2011.3
UL http://dx.doi.org/10.1001/archgenpsychiatry.2011.3
AB 
Patients with schizophrenia, and those with stimulant-induced psychosis, commonly display stress hypersensitivity and a profoundly reduced threshold for the psychotogenic action of stimulant drugs.1- 7 These effects have been linked to enhanced drug-induced striatal dopamine release.8- 10 Rodents receiving repeated intermittent amphetamine exposure display a similar “sensitization” to stress,11- 12 the psychomotor stimulatory effects of the drug,13- 19 and the elevation of striatal dopamine levels.20 Thus, amphetamine sensitization in rodents is used to model some aspects of schizophrenia.