RT Journal
T1 ARchives of general psychiatry
JF Archives of General Psychiatry
JO Archives of General Psychiatry
YR 2011
FD June 1
VO 68
IS 6
SP 541
OP 541
DO 10.1001/archgenpsychiatry.2011.52
UL http://dx.doi.org/10.1001/archgenpsychiatry.2011.52
AB 
The link between contemporary pharmacological models of schizophrenia, which emphasize dopamine dysregulation, and cognitive models focusing on disruption of distributed cortico-cortical information transmission has been highlighted by O’Daly et al Article . They used functional magnetic resonance imaging to demonstrate hyperactivity of the dorsal lateral prefrontal cortex, caudate nucleus, and thalamus following amphetamine sensitization, a well-established animal model of schizophrenia, and allied changes within the superior temporal gyrus and precuneus, similar to that seen in patients with schizophrenia.