RT Journal
A1 DAVIES BM
T1 THe methacholine test in depressive states
JF Archives of General Psychiatry
JO Archives of General Psychiatry
YR 1960
FD July 1
VO 3
IS 1
SP 14
OP 16
DO 10.1001/archpsyc.1960.01710010016003
UL http://dx.doi.org/10.1001/archpsyc.1960.01710010016003
AB Funkenstein, Greenblatt, and Solomon1 claimed that any significant alteration in a patient's mental state is invariably accompanied by a change in his physiological response to their test. Feinberg,2 reviewing the current status of the Funkenstein test, concluded that the value of the test as an objective index of clinical change could not be assessed, as this aspect of it had not been systematically studied. It is the aim of this paper to describe an investigation in which the hypothesis that clinical improvement in hospitalized patients with depressive illnesses is associated with a change in their blood pressure response to methacholine was tested.Material and Methods 
    Many of the investigations into the value of the Funkenstein test deal with tests done by different observers on patients with different types of illnesses. Often, too, the selection of patients is not clearly defined. In the present investigation, 25 consecutive admissions to one