RT Journal
A1 RODIN EE, LUBY EE
T1 EFfects of lsd-25 on the eeg and photic evoked responses
JF Archives of General Psychiatry
JO Archives of General Psychiatry
YR 1966
FD April 1
VO 14
IS 4
SP 435
OP 441
DO 10.1001/archpsyc.1966.01730100099013
UL http://dx.doi.org/10.1001/archpsyc.1966.01730100099013
AB SINCE the accidental discovery of the Psychosomimetic properties of Lysergic acid diethylamide (LSD-25) by Stoll,1 in 1947, a great amount of work has been carried out to elucidate the behavioral effects and pathophysiological mechanisms of action of this substance. The literature on this topic is steadily growing and contains now more than 1,000 publications.2There are several studies available that report on the electroencephalographic changes resulting from LSD administration to humans as seen by surface recordings3-9 and there are also some observations on changes in the human depth electrogram.10-13 It is generally agreed that the amplitude of the EEG decreases, α-rhythms tend to disappear and the tracings become of the lowvoltage fast or desynchronized type. Gastaut4 reported that the average α-frequencies are increased by 0.5 to 4 cycles per second (cps) and Grey Walter7 noted an increase from 11.6 to