RT Journal
A1 Mueller PS, Heninger GR, McDonald RK
T1 INtravenous glucose tolerance test in depression
JF Archives of General Psychiatry
JO Archives of General Psychiatry
YR 1969
FD October 1
VO 21
IS 4
SP 470
OP 477
DO 10.1001/archpsyc.1969.01740220086010
UL http://dx.doi.org/10.1001/archpsyc.1969.01740220086010
AB REPORTS on glucose utilization in depressive illness, as measured by the intravenous glucose tolerance test (GTT), are in conflict. In 1958 pryce1,2 reported that depressed patients had lower glucose utilization rates (k) than normal subjects. This lowered k was not related to loss of body weight, and it did not change significantly following successful treatment with electroconvulsive therapy (ECT). Herzberg et al in 19683 reported, however, no clear association between depression and lowered oral or intravenous GTT. These authors reported no significant change in glucose utilization rate following recovery whether ECT, tryptophan, or no somatic treatment was employed. They attributed previously reported positive findings of the GTT in depression to either malnutrition or inactivity. Pryce's data were more consistent with the report by Van Praag and Leijnse in 19654 6 where decreased glucose utilization, as measured by forearm arteriovenous glucose difference, was associated with depressive illness.