RT Journal
A1 van der Velde CD, Gordon MW
T1 MAnic-depressive illness, diabetes mellitus, and lithium carbonate
JF Archives of General Psychiatry
JO Archives of General Psychiatry
YR 1969
FD October 1
VO 21
IS 4
SP 478
OP 485
DO 10.1001/archpsyc.1969.01740220094011
UL http://dx.doi.org/10.1001/archpsyc.1969.01740220094011
AB OUR interest in the glucose metabolism of manic-depressive patients originated with the discovery of a diabetic condition in a patient whose complaints of polyuria, thirst, fatigue, and spells of profuse perspiration were initially interpreted as toxic manifestations of lithium carbonate therapy. In addition to a diabetic response to the glucose tolerance tests, a review of her hospital record revealed high-fasting blood sugar levels on several previous admissions. Similar findings among other manic-depressive patients formed the rationale of the following studies.Procedures 
    Repeated glucose tolerance tests were performed on 42 manic-depressive patients hospitalized at Norwich Hospital. The diagnoses of these patients were independently agreed upon by the referring hospital and research staff, and confirmed by their past histories as documented in their hospital records. Most of these patients were readmissions and not on medication. Some patients were receiving lithium carbonate.A second glucose tolerance survey was carried out on