RT Journal
A1 Crowe RR, Thompson JS, Flink R, Weinberger B
T1 HLa antigens and schizophrenia
JF Archives of General Psychiatry
JO Archives of General Psychiatry
YR 1979
FD February 1
VO 36
IS 2
SP 231
OP 233
DO 10.1001/archpsyc.1979.01780020121014
UL http://dx.doi.org/10.1001/archpsyc.1979.01780020121014
AB • We typed 45 schizophrenic patients for 35 HLA antigens and compared their frequencies with 1,263 population controls. No significant differences between schizophrenics and controls were found. When the schizophrenics were subtyped, a significant (P <.05) excess of Aw26 was found among the hebephrenics, compared with the population controls. When the published literature on schizophrenia-HLA associations was surveyed, none of the reported associations were found to be consistent across studies. Some possible explanations for the heterogeneity among studies are discussed and it is concluded that an association between schizophrenia and any of the HLA antigens has not yet been demonstrated.