RT Journal
A1 Tamminga CA, Crayton JW, Chase TN
T1 IMprovement in tardive dyskinesia after muscimol therapy
JF Archives of General Psychiatry
JO Archives of General Psychiatry
YR 1979
FD May 1
VO 36
IS 5
SP 595
OP 598
DO 10.1001/archpsyc.1979.01780050105013
UL http://dx.doi.org/10.1001/archpsyc.1979.01780050105013
AB • Muscimol, thought to be a agonist of γ-aminobutyric acid (GABA), was administered to eight neuroleptic-free subjects with tardive dyskinesia. At oral dose levels from 5 to 9 mg, involuntary movements were consistently attenuated, usually in the absence of sedation. These results support the view that pharmacologic attempts to stimulate GABA-mediated synaptic transmission may afford symptomatic relief to patients with tardive dyskinesia.