RT Journal
A1 Grof P
T1 Some practical aspects of lithium treatment: Blood levels, dosage prediction, and slow-release preparations
JF Archives of General Psychiatry
JO Archives of General Psychiatry
YR 1979
FD July 20
VO 36
IS 8
SP 891
OP 893
DO 10.1001/archpsyc.1979.01780080065015
UL http://dx.doi.org/10.1001/archpsyc.1979.01780080065015
AB The purpose of this report is to discuss practical issues in lithium management, focusing on (a) the reasons for standardizing procedures for drawing blood for the determination of serum lithium levels, (b) a discussion of the findings to date concerning slow-release lithium preparations, and (c) single dosage prediction of serum lithium levels, a technique particularly valuable in clinical situations that require patients to reach promptly a desired serum lithium concentration.SERUM LITHIUM LEVELS 
    Historically, the appreciation of the clinical value of serum lithium levels has developed slowly, from monitoring safety through monitoring adequacy of lithium treatment to the management of lithium intoxication. After initial disappointments, it gradually became clear that serum lithium levels can be of substantial use only if the blood samples are drawn in a standardized way. Defining the best conditions for the standardization of serum lithium levels had to take into account the pharmacokinetics of lithium as