RT Journal
A1 Bennett JP, Jr, Enna SJ, Bylund DB, Gillin J, Wyatt RJ, Snyder SH
T1 NEurotransmitter receptors in frontal cortex of schizophrenics
JF Archives of General Psychiatry
JO Archives of General Psychiatry
YR 1979
FD August 1
VO 36
IS 9
SP 927
OP 934
DO 10.1001/archpsyc.1979.01780090013001
UL http://dx.doi.org/10.1001/archpsyc.1979.01780090013001
AB • Frontal cerebral cortex brain samples from schizophrenics and controls have been assayed for binding associated with muscarinic cholinergic, serotonin (5HT), γ-aminobutyric acid (GABA), and β-adrenergic receptors as well as for the activity of the GABA-synthesizing enzyme glutamic acid decarboxylase (GAD). Binding levels of tritium-LSD, presumably associated with postsynaptic 5HT receptors, were reduced 40% to 50% in samples from schizophrenics in three independent studies, whereas no other consistent alteration was observed in levels of binding associated with other receptors or in the activity of GAD. This change in receptor binding levels does not seem to be attributable to postmortem changes, to influences of drugs received by the patients, or to demographic features of the patient populations.