RT Journal
A1 Koslow SH, Maas JW, Bowden CL, Davis JM, Hanin I, Javaid J
T1 TRicyclic antidepressant washout effects on cerebrospinal fluid and urinary monoamine and metabolites
JF Archives of General Psychiatry
JO Archives of General Psychiatry
YR 1986
FD October 1
VO 43
IS 10
SP 1012
OP 1013
DO 10.1001/archpsyc.1986.01800100106014
UL http://dx.doi.org/10.1001/archpsyc.1986.01800100106014
AB To the Editor.— 
    Our previous publication on cerebrospinal fluid (CSF) and urinary concentrations of biogenic amines and metabolites in depression reported higher concentrations in many of these measures relative to the concentrations measured from samples collected from age- and sexmatched normal healthy controls.1 The possibility exists that these higher concentrations in depressed subjects are due to an inadequate drug washout period before sample collection. This may be especially true in light of the publication by Charney et al2 that reported a rebound or increase in concentrations of plasma and urinary 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) following withdrawal of tricyclic antidepressants.2Patients and Methods.— 
    On intake into this study, all medications were withdrawn and information regarding medication usage during the current illness was obtained from all subjects and recorded on a medication review form. Drug class (eg, antidepressant, neuroleptic, anxiolytics, sedatives), specific generic information, and time of discontinuation of medication(s)