RT Journal
A1 Rapaport M, McAllister CG, Pickar D, Nelson DL, Paul SM
T1 ELevated levels of soluble interleukin 2 receptors in schizophrenia
JF Archives of General Psychiatry
JO Archives of General Psychiatry
YR 1989
FD March 1
VO 46
IS 3
SP 291
OP 292
DO 10.1001/archpsyc.1989.01810030097017
UL http://dx.doi.org/10.1001/archpsyc.1989.01810030097017
AB To the Editor — 
    Immunologic factors have been implicated in both the cause Levels of soluble interleukin 2 (IL-2) receptor in the serum of schizophrenic patients and healthy controls. Soluble IL-2 receptors were measured by a sandwich enzymelinked immunosorbent assay as previously described.7 Each point represents the value for one subject; 1 U is approximately 3 pg of soluble IL-2 receptor. Schizophrenic patients (N = 30) were diagnosed using DSMIII and Research Diagnostic Criteria. The horizontal line indicates 2 SDs above the mean value for healthy controls; asterisk, P<.001 compared with controls (N =13) by Student's t test. and pathogenesis of schizophrenia, and alterations in immune measures, such as serum and cerebrospinal fluid immunoglobulin levels, circulating B and T lymphocytes, and the presence of anti—brain autoantibodies, have been reported by some but not all laboratories.1 Problems in demonstrating consistent immunologic stigmata in schizophrenia may