RT Journal
A1 Shapiro PA, Sloan RP, Horn EM, Myers MM, Gorman JM
T1 EFfect of innervation on heart rate response to mental stress
JF Archives of General Psychiatry
JO Archives of General Psychiatry
YR 1993
FD April 1
VO 50
IS 4
SP 275
OP 279
DO 10.1001/archpsyc.1993.01820160045004
UL http://dx.doi.org/10.1001/archpsyc.1993.01820160045004
AB • Heart transplant recipients provide a useful model for study of the autonomic control of the cardiovascular response to mental stress. Utilizing the innervated native atrial tissue of heart transplant recipients as an internal control exposed to the same circulatory milieu as the denervated graft heart was exposed to, the effect of innervation on the heart rate response to a mentally stressful arithmetic task was examined in eight subjects. Compared with the graft, the innervated atrial tissue manifested a larger heart rate increase during the task, larger heart rate decrease after the task, and more rapid rate of change in heart rate during the task and recovery periods. Thus, cardiac denervation results in a chronotropic response to mental arithmetic-induced stress that is blunted and more gradual than that of the innervated heart but not completely eliminated. The cardiac chronotropic response to mental arithmetic stress is dependent on both humoral factors and, predominantly, its direct autonomic innervation.