RT Journal
A1 Arnsten AT, Steere JC, Hunt RD
T1 The contribution of α2-noradrenergic mechanisms to prefrontal cortical cognitive function: Potential significance for attention-deficit hyperactivity disorder
JF Archives of General Psychiatry
JO Archives of General Psychiatry
YR 1996
FD May 1
VO 53
IS 5
SP 448
OP 455
DO 10.1001/archpsyc.1996.01830050084013
UL http://dx.doi.org/10.1001/archpsyc.1996.01830050084013
AB This article aims to review research in nonhuman primates demonstrating that norepinephrine can enhance the cognitive functioning of the prefrontal cortex through actions at α2A-adrenergic receptors postjunctional to noradrenergic terminals. As prefrontal cortex cognitive deficits are prominent in several psychiatric disorders, including attention-deficit hyperactivity disorder, these basic findings may have relevance for the development of novel pharmacotherapies.