TY  - JOUR
T1  - MIrtazapine in the treatment of panic disorder
AU  - Carli V, Sarchiapone M, Camardese G, Romano L, DeRisio S
Y1  - 2002/07/01
N1  - 10.1001/archpsyc.59.7.661
JO  - Archives of General Psychiatry
SP  - 661
EP  - 662
VL  - 59
IS  - 7
N2  - 
Mirtazapine has been reported to target symptoms of anxiety (agitation,
somatization, psychic anxiety, panic attacks) that often occur in depressed
patients.1- 3
Enhancement of both noradrenergic and serotonergic transmission through α
autoreceptor and α-heteroreceptor antagonism, respectively, coupled
with the blockade of 5-HT2 and 5-HT3 receptors, has
been considered the main mechanism of this apparent pharmacological efficacy
for anxiety symptoms.3- 4
Additionally, H1 receptor antagonism facilitates an initial soporific
effect.

SN  - 0003-990X
M3  - doi: 10.1001/archpsyc.59.7.661
UR  - http://dx.doi.org/10.1001/archpsyc.59.7.661
ER  -