TY  - JOUR
T1  - REduced gaba concentration in attention-deficit/hyperactivity disorder
AU  - Edden RE, Crocetti D, Zhu H, Gilbert DL, Mostofsky SH
Y1  - 2012/07/01
N1  - 10.1001/archgenpsychiatry.2011.2280
JO  - Archives of General Psychiatry
SP  - 750
EP  - 753
VL  - 69
IS  - 7
N2  - Context 
                  Attention-deficit/hyperactivity disorder (ADHD) is a developmental disorder characterized by a deficit in behavioral inhibition. Recent evidence also suggests a deficit in cortical inhibition via the GABA (γ-aminobutyric acid)–ergic system.Objective 
                  To investigate the GABAergic component of ADHD using magnetic resonance spectroscopy.Design 
                  Cross-sectional study.Setting 
                  Participants were recruited through local schools, local pediatric and other community clinics, and through advertisement in regional publications. Magnetic resonance spectroscopy was performed within the research institute.Participants 
                  Children (age range, 8-12 years) in a typically developing control group vs a group with ADHD were compared.Main Outcome Measures 
                  J-difference–edited magnetic resonance spectroscopy at 3 T was used to measure GABA concentration in a volume that included primary somatosensory and motor cortices.Results 
                  GABA concentration is reduced in children with ADHD compared with typically developing control subjects.Conclusion 
                  Our finding of reduced GABA concentration in ADHD is concordant with recently reported deficits in short intracortical inhibition in ADHD and suggests a GABAergic deficit in ADHD.
SN  - 0003-990X
M3  - doi: 10.1001/archgenpsychiatry.2011.2280
UR  - http://dx.doi.org/10.1001/archgenpsychiatry.2011.2280
ER  -