TY  - JOUR
T1  - PSychiatry and cigarettes
AU  - Glassman AH
Y1  - 1998/08/01
N1  - 10.1001/archpsyc.55.8.692
JO  - Archives of General Psychiatry
SP  - 692
EP  - 693
VL  - 55
IS  - 8
N2  - 
IN THIS issue of the ARCHIVES, Hall and her colleagues1 present data indicating that nortriptyline hydrochloride, a tricyclic antidepressant, increases smoking abstinence rates. Using antidepressant drugs as aids to smoking cessation stems from the 1988 observation that cigarette smoking is associated with a history of major depression and that a history of depression predicts smoking cessation failure.2 These observations have been replicated on numerous occasions and it is now clear that nicotine withdrawal can provoke depression in smokers with a history of depression.3 These observations led a number of individual investigators as well as pharmaceutical manufacturers to hypothesize that antidepressant compounds might aid smoking cessation. However, the trials that tested this hypothesis produced unanticipated results.

SN  - 0003-990X
M3  - doi: 10.1001/archpsyc.55.8.692
UR  - http://dx.doi.org/10.1001/archpsyc.55.8.692
ER  -