TY  - JOUR
T1  - TRyptophan hydroxylase gene and manic-depressive illness
AU  - Kirov G, Owen MJ, Jones I, McCandless F, Craddock N
Y1  - 1999/01/01
N1  - 10.1001/archpsyc.56.1.98
JO  - Archives of General Psychiatry
SP  - 98
EP  - 99
VL  - 56
IS  - 1
N2  - 
We read with interest the article on a positive association between a polymorphism in the tryptophan hydroxylase (TPH) gene and manic-depressive illness.1 The authors found a significantly increased rate of the "A" allele in patients compared with control subjects (52% vs 36%).1 The TPH gene encodes for the rate-limiting enzyme of serotonin synthesis, making it a strong candidate gene for manic-depressive disorder; therefore, we attempted to replicate these results.

SN  - 0003-990X
M3  - doi: 10.1001/archpsyc.56.1.98
UR  - http://dx.doi.org/10.1001/archpsyc.56.1.98
ER  -