TY  - JOUR
T1  - CLozapine plus lamotrigine in treatment-resistant schizophrenia
AU  - Dursun SM, McIntosh D, Milliken H
Y1  - 1999/10/01
N1  - 10.1001/archpsyc.56.10.950
JO  - Archives of General Psychiatry
SP  - 950
EP  - 950
VL  - 56
IS  - 10
N2  - 
Glutamate is an excitatory neurotransmitter, and clozapine acts as a glutamate antagonist. Lamotrigine, an anticonvulsant and mood stabilizer, inhibits excessive release of glutamate.2 Both drugs block the psychotomimetic effects of phencyclidine (PCP). These schizophrenia-like symptoms are attributed to PCP's activity at the NMDA (glutamate) receptor. The biochemical significance of these glutamate interactions in schizophrenia remains unclear and is hotly debated. There is evidence to suggest that there is abnormal glutamatergic binding in the areas of the brain associated with psychotic symptoms in patients with schizophrenia.3

SN  - 0003-990X
M3  - doi: 10.1001/archpsyc.56.10.950
UR  - http://dx.doi.org/10.1001/archpsyc.56.10.950
ER  -