TY  - JOUR
T1  - THis month in archives of general psychiatry
Y1  - 2000/04/01
N1  - 10.1001/archpsyc.57.4.310
JO  - Archives of General Psychiatry
SP  - 310
EP  - 310
VL  - 57
IS  - 4
N2  - 
During the past decade several new antidepressants have gotten to market, and potential antidepressants continue to be evaluated in double-blind, placebo-controlled clinical trials. Scientists, ethicists, and the public have raised concern about risks and ethics of treating depressed patients with placebo. Khan et alArticle examined the Food and Drug Administration database for antidepressants approved during the past 10 years to assess the frequency of suicides, suicide attempts, and symptom reduction in depressed patients assigned to placebo. Rates of suicide and attempted suicide did not differ for placebo-treated vs antidepressant-treated patients. Placebo-treated patients experienced substantial reduction in symptoms. These data may help inform discussions about the use of placebo in antidepressant clinical trials.

SN  - 0003-990X
M3  - doi: 10.1001/archpsyc.57.4.310
UR  - http://dx.doi.org/10.1001/archpsyc.57.4.310
ER  -