TY  - JOUR
T1  - White matter abnormalities in obsessive-compulsive disorder: A diffusion tensor imaging study
AU  - Szeszko PR, Ardekani BA, Ashtari M, et al
Y1  - 2005/07/01
N1  - 10.1001/archpsyc.62.7.782
JO  - Archives of General Psychiatry
SP  - 782
EP  - 790
VL  - 62
IS  - 7
N2  - Context 
    Several neurobiological models of obsessive-compulsive disorder (OCD) posit a primary role for dysfunction of the anterior cingulate gyrus. Both functional and structural neuroimaging studies have implicated anterior cingulate gray matter abnormalities in the pathophysiology of OCD, but there has been little investigation of the anterior cingulate white matter in this disorder.Objective 
    To test the hypothesis that patients with OCD have abnormal white matter microstructure in the anterior cingulate gyrus compared with healthy volunteers as inferred from diffusion tensor imaging. Additional analyses examined group differences in white matter integrity across the entire brain.Design, Setting, and Participants 
    Fifteen patients with a DSM-IV diagnosis of OCD and 15 healthy volunteers matched for age, sex, and handedness underwent diffusion tensor imaging and structural magnetic resonance imaging examinations. Fractional anisotropy (FA), a robust intravoxel measure of water self-diffusion, was compared between groups on a voxel-by-voxel basis in the anterior cingulate white matter after standardization in Talairach space.Main Outcome Measures 
    Clinical ratings of symptom severity (ie, Yale-Brown Obsessive-Compulsive Scale) and FA.Results 
    Compared with healthy volunteers, patients demonstrated significantly lower FA bilaterally in 3 areas of the anterior cingulate gyrus white matter. Additional analyses conducted across the rest of the brain white matter revealed lower FA bilaterally in the parietal region (supramarginal gyri), right posterior cingulate gyrus, and left occipital lobe (lingual gyrus). No areas of significantly higher FA were observed in patients compared with healthy volunteers. Lower FA in the parietal region correlated significantly with higher Yale-Brown Obsessive-Compulsive Scale scores.Conclusions 
    These preliminary findings provide evidence of an abnormality that involves the anterior cingulate white matter in the pathogenesis of OCD and are consistent with neurobiological models that posit a defect in connectivity in the anterior cingulate basal ganglia–thalamocortical circuit. White matter abnormalities in other brain regions may also be implicated in the neurobiology of OCD.
SN  - 0003-990X
M3  - doi: 10.1001/archpsyc.62.7.782
UR  - http://dx.doi.org/10.1001/archpsyc.62.7.782
ER  -