TY  - JOUR
T1  - EFfect of team sport participation on genetic predisposition to adolescent smoking progression
AU  - Audrain-McGovern J, Rodriguez D, Wileyto E, Schmitz KH, Shields PG
Y1  - 2006/04/01
N1  - 10.1001/archpsyc.63.4.433
JO  - Archives of General Psychiatry
SP  - 433
EP  - 441
VL  - 63
IS  - 4
N2  - Context 
    There is much to be learned about why some adolescents progress to a regular smoking habit and others do not.Objective 
    To evaluate whether (1) team sport participation buffers the effect of having 2 smoking risk genotypes (the dopamine reuptake transporter [SLC6A3] and the dopamine D2 receptor [DRD2]) or 1 of these risk genotypes vs having none on adolescent smoking progression and (2) the buffering effects of team sports were due to physical activity associated with team sport participation.Design 
    Longitudinal cohort study. Survey data were collected annually from grade 9 to the end of grade 12. Self-report measures included smoking, team sport participation, physical activity, depression, smoking exposure, and alcohol and marijuana use. DNA was collected via buccal swabs. Data were analyzed using latent growth modeling.Setting 
    Five public high schools in Virginia.Participants 
    A total of 361 students of European ancestry.Main Outcome Measure 
    Smoking progression.Results 
    For adolescents participating in at least 1 team sport, but not for adolescents with no team sport participation, physical activity had a significant negative effect on smoking progression (z = −3.85, P<.001; χ21,N = 361 = 6.73, P = .009). In addition, having 1 (z = 2.69; P = .007) and 2 (z = 2.22; P = .03) smoking risk genotypes had a positive effect on physical activity. These represented significant between-group effects (χ21,N = 361 = 6.29, P = .01; χ21,N = 361 = 3.81, P = .05, respectively). Thus, having 1 or more smoking risk genotypes was related to higher levels of physical activity, which, in turn, was related to lower levels of smoking progression for adolescents participating in at least 1 team sport but not for adolescents with no team sport participation.Conclusions 
    This study provides the first evidence of an interaction between environmental influences and specific genes on adolescent smoking and may promote an understanding of important protective relationships in the environment.
SN  - 0003-990X
M3  - doi: 10.1001/archpsyc.63.4.433
UR  - http://dx.doi.org/10.1001/archpsyc.63.4.433
ER  -