TY  - JOUR
T1  - A primary candidate gene for obsessive-compulsive disorder
AU  - Leckman JF, Kim Y
Y1  - 2006/07/01
N1  - 10.1001/archpsyc.63.7.717
JO  - Archives of General Psychiatry
SP  - 717
EP  - 720
VL  - 63
IS  - 7
N2  - 
Although dozens of genes have been linked to psychiatric disorders, connecting the dots between behavioral phenotypes and genetic variations has not been easy. In this issue of the Archives, 2 groups of investigators report that statistically significant associations between the transmission of obsessive-compulsive disorder (OCD) for male but not female offspring, and a genetic locus on chromosome 9p24 that codes for a high-affinity neuronal/epithelial excitatory amino acid transporter (ECCA-1) known in the genetic world as SLC1A1 (solute carrier family 1, member 1; Online Mendelian Inheritance in Man [OMIM] 133550).1- 2 In the brain, this transporter is crucial in terminating the action of the excitatory neurotransmitter glutamate and in maintaining extracellular glutamate concentrations within a normal range.

SN  - 0003-990X
M3  - doi: 10.1001/archpsyc.63.7.717
UR  - http://dx.doi.org/10.1001/archpsyc.63.7.717
ER  -