TY  - JOUR
T1  - Evidence that familial liability for psychosis is expressed as differential sensitivity to cannabis: An analysis of patient-sibling and sibling-control pairs
AU  - et al
Y1  - 2011/02/07
N1  - 10.1001/archgenpsychiatry.2010.132
JO  - Archives of General Psychiatry
SP  - 138
EP  - 147
VL  - 68
IS  - 2
N2  - 
Randomized controlled experiments have shown that acute exposure to Δ9-tetrahydrocannabinol, the main psychotropic component of Cannabis sativa, induces psychotic symptoms in a substantial proportion of healthy controls.1- 2 Meta-analysis3- 4 of prospective epidemiological studies indicates that cannabis use not only predicts onset of psychotic disorder but also is associated with subthreshold expression of psychosis either in the form of schizotypy5- 7 or subclinical psychotic experiences.8- 10 Schizotypy and subclinical psychotic experiences represent related phenotypes; the positive and negative dimensions of the Structured Interview for Schizotypy–Revised (SIS-R) correlate strongly with the equivalent dimensions of self-reported psychotic experiences,11 and both measures of schizotypy and measures of subclinical psychotic experiences display familial clustering with psychotic disorder.12- 18 The results therefore suggest that cannabis may provoke a psychotic response in individuals with higher-than-average vulnerability for psychotic disorder.

SN  - 0003-990X
M3  - doi: 10.1001/archgenpsychiatry.2010.132
UR  - http://dx.doi.org/10.1001/archgenpsychiatry.2010.132
ER  -