TY  - JOUR
T1  - FUnctional magnetic resonance imaging investigation of the amphetamine sensitization model of schizophrenia in healthy male volunteers
AU  - O’Daly O, Joyce D, Stephan K, Murray R, Shergill SS
Y1  - 2011/06/06
N1  - 10.1001/archgenpsychiatry.2011.3
JO  - Archives of General Psychiatry
SP  - 545
EP  - 554
VL  - 68
IS  - 6
N2  - 
Patients with schizophrenia, and those with stimulant-induced psychosis, commonly display stress hypersensitivity and a profoundly reduced threshold for the psychotogenic action of stimulant drugs.1- 7 These effects have been linked to enhanced drug-induced striatal dopamine release.8- 10 Rodents receiving repeated intermittent amphetamine exposure display a similar “sensitization” to stress,11- 12 the psychomotor stimulatory effects of the drug,13- 19 and the elevation of striatal dopamine levels.20 Thus, amphetamine sensitization in rodents is used to model some aspects of schizophrenia.

SN  - 0003-990X
M3  - doi: 10.1001/archgenpsychiatry.2011.3
UR  - http://dx.doi.org/10.1001/archgenpsychiatry.2011.3
ER  -