TY  - JOUR
T1  - PRolongation of brainstem auditory-evoked responses in autistic probands and their unaffected relatives
AU  - Maziade M, Mérette C, Cayer M, et al
Y1  - 2000/11/01
N1  - 10.1001/archpsyc.57.11.1077
JO  - Archives of General Psychiatry
SP  - 1077
EP  - 1083
VL  - 57
IS  - 11
N2  - Background 
    Brain function, as indexed by brain electrical activity, is heritable in humans, and it may be impaired in autism. Autism also has strong genetic determinants, and like all major psychiatric disorders, its complex clinical phenotype renders genetic studies difficult. Innovative strategies focused on alternative biological phenotypes are needed.Methods 
    The early brain auditory-evoked response was assessed in 73 autistic probands and 251 relatives who were compared with 521 normal controls.Results 
    We first confirmed in the autistic probands the presence of a slowing in nerve conduction in the auditory system as expressed by the prolongation of early brain auditory-evoked response under the form of I-III interpeak latencies (IPLs). Furthermore, we observed the same I-III IPL prolongation in the unaffected first degree relatives of the autistic probands compared with controls. Despite clear evidence of a coaggregation of autism and I-III IPL prolongation in families, the IPLs did not seem to be the sole liability factor for autism as suggested by the observation of 52% of families in which the autistic proband and relatives showed normal IPLs.Conclusion 
    A prolongation of the early brain auditory-evoked response IPLs may be a marker for one of several deficits underlying autism and deserves further analysis as a potential alternative phenotype for the disorder.
SN  - 0003-990X
M3  - doi: 10.1001/archpsyc.57.11.1077
UR  - http://dx.doi.org/10.1001/archpsyc.57.11.1077
ER  -