TY  - JOUR
T1  - ALtered cerebral γ-aminobutyric acid type a–benzodiazepine receptor binding in panic disorder determined by [11c]flumazenil positron emission tomography
AU  - Hasler G, Nugent AC, Carlson PJ, Carson RE, Geraci M, Drevets WC
Y1  - 2008/10/06
N1  - 10.1001/archpsyc.65.10.1166
JO  - Archives of General Psychiatry
SP  - 1166
EP  - 1175
VL  - 65
IS  - 10
N2  - Context 
    The benzodiazepine (BZD) receptor system has been implicated in the pathophysiologic mechanism of panic disorder (PD) by indirect evidence from pharmacological challenge studies and by direct evidence from single-photon emission computed tomography and positron emission tomography neuroimaging studies. However, the results of previous neuroimaging studies are in disagreement, possibly because of experimental design limitations related to sample size, matching between patients and controls, and confounding medication effects.Objective 
    To compare BZD receptor binding between subjects with PD and healthy control subjects.Design 
    Cross-sectional study for association.Setting 
    Psychiatric outpatient clinic of the National Institute of Mental Health.Participants 
    Fifteen subjects with PD who were naïve to BZD drug exposure and were not receiving other drug treatment, and 18 healthy controls.Intervention 
    Images of BZD receptor binding were acquired using positron emission tomography and flumazenil tagged with carbon 11.Main Outcome Measures 
    The BZD receptor binding potential was assessed by a simplified reference tissue-tracer kinetic model.Results 
    The BZD receptor binding potential was decreased in multiple areas of the frontal, temporal, and parietal cortices and was increased in the hippocampus/parahippocampal region in subjects with PD vs controls. The most significant decrease was located in the dorsal anterolateral prefrontal cortex (DALPFC); the most significant increase, in the hippocampus/parahippocampal gyrus. These abnormalities were not accounted for by comorbid depression. In subjects with PD, the severity of panic and anxiety symptoms correlated positively with BZD receptor binding in the DALPFC but negatively with binding in the hippocampus/parahippocampal gyrus.Conclusions 
    These data provide evidence of abnormal BZD–γ-aminobutyric acid type A receptor binding in PD, suggesting that basal and/or compensatory changes in inhibitory neurotransmission play roles in the pathophysiologic mechanism of PD. They also provide evidence of an impairment of frontal-limbic interaction in the modulation of anxiety responses, consistent with previous functional and structural neuroimaging studies in PD.
SN  - 0003-990X
M3  - doi: 10.1001/archpsyc.65.10.1166
UR  - http://dx.doi.org/10.1001/archpsyc.65.10.1166
ER  -