TY  - JOUR
T1  - ASsociation of variants in manea with cocaine-related behaviors
AU  - Farrer LA, Kranzler HR, Yu Y, et al
Y1  - 2009/03/01
N1  - 10.1001/archgenpsychiatry.2008.538
JO  - Archives of General Psychiatry
SP  - 267
EP  - 274
VL  - 66
IS  - 3
N2  - Context 
    Cocaine dependence (CD) and related behaviors are highly heritable, but no genetic association has been consistently demonstrated. A recent genome-wide study of drug dependence identified an association between cocaine-induced paranoia (CIP) and a single-nucleotide polymorphism (SNP) in the α-endomannosidase (MANEA) locus in a family-based sample of European Americans and African Americans.Objective 
    To conduct a comprehensive genetic association study of the MANEA locus with CD and CIP.Design 
    Genome-wide association study.Setting 
    Four university hospitals.Participants 
    A total of 3992 individuals from 2 family-based and 2 case-control samples.Intervention 
    Participants were classified as having CD or CIP or as a control using the Semi-Structured Assessment for Drug Dependence and Alcoholism. They were genotyped for 11 SNPs spanning MANEA and its surrounding region.Main Outcome Measure 
    Association of CD and CIP with individual SNPs and haplotypes.Results 
    Cocaine-induced paranoia was associated with 6 SNPs in the European American families and 9 SNPs in the African American families. The strongest evidence in the total sample of families was observed in 3 markers located in the promoter and 3′ untranslated regions (P < .001). The association of MANEA SNPs with CD in both family samples was much weaker. In the African American case-control sample, multiple markers were significantly associated with CIP and CD; CIP and CD were also significantly associated with a 2-SNP haplotype in the European American case-control sample. The A allele of the 3′ untranslated region SNP rs9387522 was associated with increased risk of CIP in all 4 data sets.Conclusions 
    Our findings suggest that CD and associated behaviors may involve biological pathways not typically thought to be associated with brain metabolism.
SN  - 0003-990X
M3  - doi: 10.1001/archgenpsychiatry.2008.538
UR  - http://dx.doi.org/10.1001/archgenpsychiatry.2008.538
ER  -