TY  - JOUR
T1  - ALcohol and central serotonin metabolism in man
AU  - Ballenger JC, Goodwin FK, Major LF, Brown GL
Y1  - 1979/02/01
N1  - 10.1001/archpsyc.1979.01780020114013
JO  - Archives of General Psychiatry
SP  - 224
EP  - 227
VL  - 36
IS  - 2
N2  - • Animal studies and some of the phenomena associated with alcoholism in humans suggest that some central effects of alcohol may involve serotonergic systems. The CSF metabolites of serotonin and dopamine, 5-hydroxyindoleacetic acid (5HIAA), and homovanillic acid (HVA) were studied in hospitalized alcoholics. There were no significant differences in HVA levels between groups. The level of 5HIAA of alcoholics in the abstinence phase, 28 to 63 days after their last drink, was significantly lower (21.8 ± 1.9 ng/ml) than both a nonalcoholic comparison group (31.7 ± 2.0 ng/ml) and alcoholics in the immediate postintoxication phase, within one to two days after their last drink (32.3 ± 2.9 ng/mL).
SN  - 0003-990X
M3  - doi: 10.1001/archpsyc.1979.01780020114013
UR  - http://dx.doi.org/10.1001/archpsyc.1979.01780020114013
ER  -