TY  - JOUR
T1  - CLomipramine-induced mania in unipolar depression
AU  - van Scheyen JD, van Kammen DP
Y1  - 1979/05/01
N1  - 10.1001/archpsyc.1979.01780050070008
JO  - Archives of General Psychiatry
SP  - 560
EP  - 565
VL  - 36
IS  - 5
N2  - • Manic behavior during randomly assigned treatment with clomipramine (chlorimipramine) or amitriptyline hydrochloride developed in seven of 50 hospitalized unipolar depressed patients. Six of the 25 clomipramine-treated patients became manic. Only one patient in the amitriptyline-treated group developed manic behavior. The switch into mania occurred at the mean age of 63, much later than the reported age of risk for mania. Significant correlations were observed between the age at onset of mania, the number of days of clomipramine treatment, and the duration of the manic episode. We hypothesize that such a switch into mania in unipolar patients is triggered by the psychopharmacological effect of clomipramine through an alleged change in activity of the central dopamine and serotonin systems.
SN  - 0003-990X
M3  - doi: 10.1001/archpsyc.1979.01780050070008
UR  - http://dx.doi.org/10.1001/archpsyc.1979.01780050070008
ER  -