TY  - JOUR
T1  - LIthium as an antidepressant
AU  - Mendels J, Ramsey T, Dyson WL, Frazer A
Y1  - 1979/07/20
N1  - 10.1001/archpsyc.1979.01780080019004
JO  - Archives of General Psychiatry
SP  - 845
EP  - 846
VL  - 36
IS  - 8
N2  - Evidence has been accumulating from several sources in support of the claim that lithium is an effective antidepressant in a subgroup of depressed patients. The acceptance of this has been somewhat impaired by the availability of the tricyclic compounds that are relatively effective in a much larger number of depressed patients. Further, lithium's clear antimanic action has prompted resistance to the implications that a single compound is both antidepressant and antimanic.The evidence for lithium's antidepressant action derives from 12 controlled studies that have been conducted in nine different centers (Table). Three of these1-3 concluded that lithium was not an antidepressant, while the remaining nine4-11 all reported a significant antidepressnat effect. These studies have been reviewed in detail else-where.10,12,13Also listed in this table is the most recent study from our group (T. A. Ramsey, MD, W. Dyson, MD, J. Mendels, MD, et al; unpublished findings, 1978), a single-blind study in
SN  - 0003-990X
M3  - doi: 10.1001/archpsyc.1979.01780080019004
UR  - http://dx.doi.org/10.1001/archpsyc.1979.01780080019004
ER  -