TY - JOUR T1 - SErendipity in biological psychiatry—a myth? AU - Jeste DV, Gillin J, Wyatt R Y1 - 1979/10/01 N1 - 10.1001/archpsyc.1979.01780110027003 JO - Archives of General Psychiatry SP - 1173 EP - 1178 VL - 36 IS - 11 N2 - • It is often stated that major biological treatments in psychiatry were discovered by accident or serendipity. Tracing the history of the concept of serendipity, we find that serendipity has been subjected to greatly divergent interpretations. According to the current usage, it is a discovery in which chance was a necessary and/or sufficient condition. With this definition, none of the discoveries of major biological treatments in psychiatry can be labeled serendipitous. The necessary factors common to these discoveries were creative minds that were variably influenced by the zeitgeist and that were persistent in their search for answers. Another important prerequisite was the availability of crucial basic knowledge of many related sciences. We conclude that chance cannot substitute for long-term research and that the latter is the most likely way to lead to valuable discoveries. SN - 0003-990X M3 - doi: 10.1001/archpsyc.1979.01780110027003 UR - http://dx.doi.org/10.1001/archpsyc.1979.01780110027003 ER -