TY  - JOUR
T1  - EStimation of haplotypes at drd2 may have produced misleading results
AU  - Curtis D, Gurling H
Y1  - 2006/08/01
N1  - 10.1001/archpsyc.63.8.939-a
JO  - Archives of General Psychiatry
SP  - 939
EP  - 939
VL  - 63
IS  - 8
N2  - 
We are concerned that the results appearing to implicate an effect of DRD2 polymorphisms on the susceptibility to heroin dependence1 may represent statistical artifacts rather than a true genetic effect. To a very large extent, the results are based on estimating the frequencies of haplotypes in cases and controls and testing for a difference, the frequencies being estimated using the MLOCUS program.2 Likelihood ratio tests assuming a χ2 distribution were reported to produce P values as low as 10−10. A Fisher exact test for 1 haplotype produced a P value of 10−22.

SN  - 0003-990X
M3  - doi: 10.1001/archpsyc.63.8.939-a
UR  - http://dx.doi.org/10.1001/archpsyc.63.8.939-a
ER  -