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Boyle and coauthors used data from a longitudinal epidemiologic, clinicopathologic study of aging that included detailed annual clinical evaluations and brain autopsy to determine the risk of Alzheimer disease in persons with a strong sense of purpose in life.
In a case-control study, Kegeles et al measure γ-aminobutyric acid and glutamate-glutamine levels in vivo in 2 prefrontal brain regions in unmedicated and medicated patients with schizophrenia and healthy controls.
Joffe et al evaluate whether previous affective illness is associated with low health-related quality of life during midlife in the absence of current illness episodes.
In a case-control study, Grosshans and coauthors assess changes in regional brain activations in response to food-related cues in association with body mass index and the plasma concentration of the appetite regulating peptide leptin.
Articles published ahead of print
Original Article | May 7, 2012
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