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 Showing 1-18 of 18 Articles
Original Investigation  FREE
Lee M. Hampton, MD, MSc; Matthew Daubresse, MHS; Hsien-Yen Chang, PhD; G. Caleb Alexander, MD, MS; Daniel S. Budnitz, MD, MPH
Includes: Supplemental Content

Importance  In 2011, an estimated 26.8 million US adults used prescription medications for mental illness.

Objective  To estimate the numbers and rates of adverse drug event (ADE) emergency department (ED) visits involving psychiatric medications among US adults between January 1, 2009, and December 31, 2011.

Design ...

Original Investigation 
Sarah L. Karalunas, PhD; Damien Fair, PhD; Erica D. Musser, PhD; Kamari Aykes, BS; Swathi P. Iyer, MS; Joel T. Nigg, PhD
Includes: Supplemental Content

Importance  Psychiatric nosology is limited by behavioral and biological heterogeneity within existing disorder categories. The imprecise nature of current nosologic distinctions limits both mechanistic understanding and clinical prediction. We demonstrate an approach consistent with the National Institute of Mental Health Research Domain Criteria initiative to identify superior, ...

Original Investigation 
Benjamin B. Lahey, PhD; David H. Zald, PhD; Jahn K. Hakes, PhD; Robert F. Krueger, PhD; Paul J. Rathouz, PhD

Importance  Mental disorders predict future occurrences of both the same disorder (homotypic continuity) and other disorders (heterotypic continuity). Heterotypic continuity is inconsistent with a view of mental disorders as fixed entities. In contrast, hierarchical-dimensional conceptualizations of psychopathology, in which each form of psychopathology is hypothesized to have ...

Original Investigation 
W. Curt LaFrance Jr, MD, MPH; Grayson L. Baird, MS; John J. Barry, MD; Andrew S. Blum, MD, PhD; Anne Frank Webb, MA; Gabor I. Keitner, MD; Jason T. Machan, PhD; Ivan Miller, PhD; Jerzy P. Szaflarski, MD, PhD; for the NES Treatment Trial (NEST-T) Consortium
Includes: Supplemental Content

Importance  There is a paucity of controlled treatment trials for the treatment of conversion disorder, seizures type, also known as psychogenic nonepileptic seizures (PNES). Psychogenic nonepileptic seizures, the most common conversion disorder, are as disabling as epilepsy and are not adequately addressed or treated by mental health ...

Original Investigation 
Therese Ljung, PhD; Qi Chen, MSc; Paul Lichtenstein, PhD; Henrik Larsson, PhD
Includes: Supplemental Content

Importance  The prevention of suicidal behavior is one of the most important tasks for mental health clinicians. Although a few studies have indicated an increased risk of suicidal behavior among individuals with attention-deficit/hyperactivity disorder, the development of more effective ways of identifying and modifying the risk is ...

Original Investigation 
Rosa Alati, PhD, MApplSc; Kim S. Betts, MPH; Gail M. Williams, PhD, MSc; Jacob M. Najman, PhD; Wayne D. Hall, PhD

Importance  Increases in alcohol use in young women over recent decades are shown by national survey data but have yet to be replicated using prospective data.

Objective  To compare change in alcohol use over a generation of young women born in Australia from 1981 to 1983 ...

Original Investigation 
Thomas J. Hoffmann, PhD; Gayle C. Windham, PhD; Meredith Anderson, MA; Lisa A. Croen, PhD; Judith K. Grether, PhD; Neil Risch, PhD

Importance  Few studies have examined the curtailment of reproduction (ie, stoppage) after the diagnosis of a child with autism spectrum disorder (ASD).

Objective  To examine stoppage in a large, population-based cohort of families in which a child has received a diagnosis of ASD.

Design, Setting, and ...

Original Investigation 
Kristen Lyall, ScD; John N. Constantino, MD; Marc G. Weisskopf, PhD, ScD; Andrea L. Roberts, PhD; Alberto Ascherio, MD, DrPH; Susan L. Santangelo, ScD
Includes: Supplemental Content

Importance  Although autism spectrum disorder (ASD) is known to be heritable, patterns of inheritance of subclinical autistic traits in nonclinical samples are poorly understood.

Objective  To examine the familiality of Social Responsiveness Scale (SRS) scores of individuals with and without ASD.

Design, Setting, and Participants  ...

Original Investigation 
Ezra Wegbreit, PhD; Grace K. Cushman, BS; Megan E. Puzia, BA; Alexandra B. Weissman, BA; Kerri L. Kim, PhD; Angela R. Laird, PhD; Daniel P. Dickstein, MD
Includes: Supplemental Content

Importance  Bipolar disorder (BD) is a debilitating mental illness associated with high costs to diagnosed individuals and society. Within the past 2 decades, increasing numbers of children and adolescents have been diagnosed as having BD. While functional magnetic resonance imaging (fMRI) studies have begun to investigate the ...

Editorial 
Sonia J. Lupien, PhD
Three individuals with a substance use disorder enter an inpatient 12-step program in a community mental health center and for the first month of the program, all 3 individuals are abstinent. They are then discharged from inpatient treatment and return for face-to-face follow-up interviews at 14, 30, and 90 days ...
Original Investigation 
Kimberly Ann Yonkers, MD; Megan V. Smith, DrPh; Ariadna Forray, MD; C. Neill Epperson, MD; Darce Costello, EdD; Haiqun Lin, PhD, MD; Kathleen Belanger, PhD†
Includes: Supplemental Content

Importance  Posttraumatic stress disorder (PTSD) occurs in about 8% of pregnant women. Stressful conditions, including PTSD, are inconsistently linked to preterm birth. Psychotropic treatment has been frequently associated with preterm birth. Identifying whether the psychiatric illness or its treatment is independently associated with preterm birth may help ...

Original Investigation 
Monika A. Waszczuk, MSc; Helena M. S. Zavos, PhD; Alice M. Gregory, PhD; Thalia C. Eley, PhD
Includes: Supplemental Content

Importance  The DSM-5 classifies mood and anxiety disorders as separate conditions. However, some studies in adults find a unidimensional internalizing factor that underpins anxiety and depression, while others support a bidimensional model where symptoms segregate into distress (depression and generalized anxiety) and fear factors (phobia subscales). However, ...

Original Investigation 
Nicholas T. Van Dam, PhD; Kenneth Rando, BS; Marc N. Potenza, PhD, MD; Keri Tuit, PsyD; Rajita Sinha, PhD
Includes: Supplemental Content

Importance  Substance use disorders (SUDs) are among the most common sequelae of childhood maltreatment, yet the independent contributions of SUDs and childhood maltreatment to neurobiological changes and the effect of the latter on relapse risk (a critical variable in addiction treatment) are relatively unknown.

Objectives  To ...

Editorial 
C. Neill Epperson, MD; Deborah R. Kim, MD; Tracy L. Bale, PhD
Sex differences in the timing of onset, prevalence, and clinical course of neuropsychiatric and substance use disorders provide clues to the underlying pathophysiology of these disorders. Disorders that occur more frequently in males tend to be neurodevelopmental in nature and include attention-deficit/hyperactivity disorder, autism, Tourette syndrome, oppositional defiant disorder, and, ...
Original Investigation 
Paraskevi Vivien Rekkas, PhD; Alan A. Wilson, PhD; Vivian Wai Han Lee, BSc; Priyanga Yogalingam, BSc; Julia Sacher, MD, PhD; Pablo Rusjan, PhD; Sylvain Houle, MD, PhD; Donna E. Stewart, MD; Nathan J. Kolla, MSc, MD; Stephen Kish, PhD; Lina Chiuccariello, MSc; Jeffrey H. Meyer, MD, PhD
Includes: Supplemental Content

Importance  Perimenopause is a period of high risk for mood disorders, and it has been proposed that perimenopause is also a window of risk for processes linked to later dementia. However, in human perimenopause, the neurobiological changes implicated in the genesis of mood disorders or dementia have ...

Original Investigation 
Aurélie M. Lasserre, MD; Jennifer Glaus, PhD; Caroline L. Vandeleur, PhD; Pedro Marques-Vidal, MD, PhD; Julien Vaucher, MD; François Bastardot, MD; Gérard Waeber, MD; Peter Vollenweider, MD; Martin Preisig, MD, MPH
Includes: Supplemental Content

Importance  Depression and obesity are 2 prevalent disorders that have been repeatedly shown to be associated. However, the mechanisms and temporal sequence underlying this association are poorly understood.

Objective  To determine whether the subtypes of major depressive disorder (MDD; melancholic, atypical, combined, or unspecified) are predictive ...

Original Investigation 
Sarah R. Blumenthal, BS; Victor M. Castro, MS; Caitlin C. Clements, BA; Hannah R. Rosenfield, BA; Shawn N. Murphy, MD, PhD; Maurizio Fava, MD; Jeffrey B. Weilburg, MD; Jane L. Erb, MD; Susanne E. Churchill, PhD; Isaac S. Kohane, MD; Jordan W. Smoller, MD, ScD; Roy H. Perlis, MD, MSc
Includes: Supplemental Content

Importance  Short-term studies suggest antidepressants are associated with modest weight gain but little is known about longer-term effects and differences between individual medications in general clinical populations.

Objective  To estimate weight gain associated with specific antidepressants over the 12 months following initial prescription in a large ...

Reviewers List  FREE
Joseph T. Coyle, MD
The following is a list of the reviewers of manuscripts submitted to the Archives of General Psychiatry during 2011. As the Editor, I feel that the many hours reviewers give gratis to ensure that authors can present the highest quality of science is underappreciated by the public but incredibly valuable ...

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