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Basic View | Expanded View
 Showing 1-20 of 27 Articles
Original Investigation 
Amelia Versace, MD; Heather Acuff, BS; Michele A. Bertocci, PhD; Genna Bebko, PhD; Jorge R. C. Almeida, MD, PhD; Susan B. Perlman, PhD; Alexander Leemans, PhD; Claudiu Schirda, PhD; Haris Aslam, BA; Amanda Dwojak, BA; Lisa Bonar, BS; Michael Travis, MD; Mary Kay Gill, RN, MSN; Christine Demeter, MA; Vaibhav A. Diwadkar, PhD; Jeffrey L. Sunshine, MD, PhD; Scott K. Holland, PhD; Robert. A. Kowatch, MD, PhD; Boris Birmaher, MD; David Axelson, MD; Sarah M. Horwitz, PhD; Thomas W. Frazier, PhD; L. Eugene Arnold, MD, MEd; Mary. A Fristad, PhD, ABPP; Eric A. Youngstrom, PhD; Robert L. Findling, MD, MBA; Mary L. Phillips, MD, MD(Cantab)
Includes: Supplemental Content

Importance  Psychiatric disorders in youth characterized by behavioral and emotional dysregulation are often comorbid and difficult to distinguish. An alternative approach to conceptualizing these disorders is to move toward a diagnostic system based on underlying pathophysiologic processes that may cut across conventionally defined diagnoses. Neuroimaging techniques have ...

Original Investigation 
Jacob A. S. Vorstman, MD, PhD; Elemi J. Breetvelt, MD, PhD; Sasja N. Duijff, PhD; Stephan Eliez, MD; Maude Schneider, MSc; Maria Jalbrzikowski, PhD; Marco Armando, MD, PhD; Stefano Vicari, MD, PhD; Vandana Shashi, MD; Stephen R. Hooper, PhD; Eva W. C. Chow, MD, MPH, FRCPC; Wai Lun Alan Fung, MD, ScD, FRCPC; Nancy J. Butcher, MSc; Donald A. Young, PhD, EdD; Donna M. McDonald-McGinn, MS, CGC; Annick Vogels, MD, PhD; Therese van Amelsvoort, MD, PhD; Doron Gothelf, MD; Ronnie Weinberger, MA; Abraham Weizman, MD; Petra W. J. Klaassen, MSc; Sanne Koops, MSc; Wendy R. Kates, PhD; Kevin M. Antshel, PhD; Tony J. Simon, PhD; Opal Y. Ousley, PhD; Ann Swillen, PhD; Raquel E. Gur, MD, PhD; Carrie E. Bearden, PhD; René S. Kahn, MD, PhD; Anne S. Bassett, MD, FRCPC; for the International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome
Includes: Supplemental Content

Importance  Patients with 22q11.2 deletion syndrome (22q11DS) have an elevated (25%) risk of developing schizophrenia. Recent reports have suggested that a subgroup of children with 22q11DS display a substantial decline in cognitive abilities starting at a young age.

Objective  To determine whether early cognitive decline is ...

Original Investigation 
Jordan E. DeVylder, PhD; Ellen P. Lukens, PhD, MSW; Bruce G. Link, PhD; Jeffrey A. Lieberman, MD

Importance  Suicide is a leading cause of preventable death, especially among individuals with psychotic disorders, and may also be common among nonclinical populations of adults with subthreshold psychotic experiences. Understanding this association has the potential to critically bolster suicide prevention efforts.

Objectives  To examine the association ...

Original Investigation 
Matthew P. Hyett, BSc, PGDipPsych; Michael J. Breakspear, MBBS, PhD, FRANZCP; Karl J. Friston, MBBS, MRCPsych, FRS; Christine C. Guo, PhD; Gordon B. Parker, MD, PhD, FRANZCP
Includes: Supplemental Content

Importance  Patients with melancholia report a distinct and intrusive dysphoric state during internally generated thought. Melancholia has long been considered to have a strong biological component, but evidence for its specific neurobiological origins is limited. The distinct neurocognitive, psychomotor, and mood disturbances observed in melancholia do, however, ...

Original Investigation 
Heidi A. Browne, BSc; Stefan N. Hansen, MSc; Joseph D. Buxbaum, PhD; Shannon L. Gair, BA; Judith B. Nissen, MD, PhD; Kathrine H. Nikolajsen, MD; Diana E. Schendel, PhD; Abraham Reichenberg, PhD; Erik T. Parner, PhD; Dorothy E. Grice, MD
Includes: Supplemental Content

Importance  Tourette syndrome/chronic tic disorder (TS/CT) and obsessive-compulsive disorder (OCD) overlap in their phenomenological features and often co-occur in affected individuals and families. Understanding how these disorders cluster in families provides important clinical information and is an important step in understanding the causes of these disorders.

Objective...

Research Letter 
Robert H. Pietrzak, PhD, MPH; Lynnette A. Averill, PhD; Chadi G. Abdallah, MD; Alexander Neumeister, MD; John H. Krystal, MD; Ifat Levy, PhD; Ilan Harpaz-Rotem, PhD
The amygdala and hippocampus have been implicated consistently in the pathophysiology of posttraumatic stress disorder (PTSD).1,2 While several studies have observed reduced hippocampal volume in PTSD, studies of amygdala volume and PTSD have been mixed.1- 3
Original Investigation 
Jeffrey F. Scherrer, PhD; Hong Xian, PhD; Wendy S. Slutske, PhD; Seth A. Eisen, MD, MSc; Marc N. Potenza, MD, PhD
Includes: Supplemental Content

Importance  Because of shared characteristics, pathological gambling (PG) has been variously conceptualized as an obsessive-compulsive (OC) spectrum disorder or as an addictive disorder. Prior community-based studies have not systematically determined the association between PG and OC features and whether common genetic factors contribute to both conditions.

Objective...

Original Investigation 
Elizabeth Reisinger Walker, PhD, MPH, MAT; Robin E. McGee, MPH; Benjamin G. Druss, MD, MPH
Includes: Supplemental Content

Importance  Despite the potential importance of understanding excess mortality among people with mental disorders, no comprehensive meta-analyses have been conducted quantifying mortality across mental disorders.

Objective  To conduct a systematic review and meta-analysis of mortality among people with mental disorders and examine differences in mortality risks ...

Original Investigation 
Matthew E. Hirschtritt, MD, MPH; Paul C. Lee, MD, MPH; David L. Pauls, PhD; Yves Dion, MD; Marco A. Grados, MD; Cornelia Illmann, PhD; Robert A. King, MD; Paul Sandor, MD; William M. McMahon, MD; Gholson J. Lyon, MD, PhD; Danielle C. Cath, MD, PhD; Roger Kurlan, MD; Mary M. Robertson, MBChB, MD, DSc(Med), FRCP, FRCPCH, FRCPsych; Lisa Osiecki, BA; Jeremiah M. Scharf, MD, PhD; Carol A. Mathews, MD; for the Tourette Syndrome Association International Consortium for Genetics
Includes: Supplemental Content

Importance  Tourette syndrome (TS) is characterized by high rates of psychiatric comorbidity; however, few studies have fully characterized these comorbidities. Furthermore, most studies have included relatively few participants (<200), and none has examined the ages of highest risk for each TS-associated comorbidity or their etiologic relationship to ...

Research Letter 
Stacey C. Sigmon, PhD
Opioid abuse and dependence are reaching epidemic proportions in the United States, resulting in a staggering number of overdose deaths1 and economic costs that exceed $56 billion annually.2 Medication-assisted therapies, such as buprenorphine (Suboxone) and methadone, represent the most efficacious treatments for opioid dependence. Office-based buprenorphine treatment is especially well ...
Viewpoint 
Arthur Robin Williams, MD, MBE; Mark Olfson, MD, MPH; Marc Galanter, MD
This Viewpoint discusses the differences between patients experiencing denial and those exhibiting lack of insight and addresses interventions that may improve care for patients exhibiting lack of insight.
Original Investigation  FREE
Madeleine Goodkind, PhD; Simon B. Eickhoff, DrMed; Desmond J. Oathes, PhD; Ying Jiang, MD; Andrew Chang, BS; Laura B. Jones-Hagata, MA; Brissa N. Ortega, BS; Yevgeniya V. Zaiko, BA; Erika L. Roach, BA; Mayuresh S. Korgaonkar, PhD; Stuart M. Grieve, DPhil; Isaac Galatzer-Levy, PhD; Peter T. Fox, MD; Amit Etkin, MD, PhD
Includes: Supplemental Content

Importance  Psychiatric diagnoses are currently distinguished based on sets of specific symptoms. However, genetic and clinical analyses find similarities across a wide variety of diagnoses, suggesting that a common neurobiological substrate may exist across mental illness.

Objective  To conduct a meta-analysis of structural neuroimaging studies across ...

Original Investigation 
Mark Slifstein, PhD; Elsmarieke van de Giessen, MD, PhD; Jared Van Snellenberg, PhD; Judy L. Thompson, PhD; Rajesh Narendran, MD; Roberto Gil, MD; Elizabeth Hackett, RT; Ragy Girgis, MD; Najate Ojeil, MS; Holly Moore, PhD; Deepak D’Souza, MD; Robert T. Malison, MD; Yiyun Huang, PhD; Keunpoong Lim, PhD; Nabeel Nabulsi, PhD; Richard E. Carson, PhD; Jeffrey A. Lieberman, MD; Anissa Abi-Dargham, MD
Includes: Supplemental Content

Importance  Multiple lines of evidence suggest a deficit in dopamine release in the prefrontal cortex (PFC) in schizophrenia. Despite the prevalence of the concept of prefrontal cortical hypodopaminergia in schizophrenia, in vivo imaging of dopamine release in the PFC has not been possible until now, when the ...

Original Investigation 
Elaine Setiawan, PhD; Alan A. Wilson, PhD; Romina Mizrahi, MD, PhD; Pablo M. Rusjan, PhD; Laura Miler, HBSc; Grazyna Rajkowska, PhD; Ivonne Suridjan, HBSc; James L. Kennedy, MD; P. Vivien Rekkas, PhD; Sylvain Houle, MD, PhD; Jeffrey H. Meyer, MD, PhD, FRCPC
Includes: Supplemental Content

Importance  The neuroinflammatory hypothesis of major depressive disorder is supported by several main findings. First, in humans and animals, activation of the immune system causes sickness behaviors that present during a major depressive episode (MDE), such as low mood, anhedonia, anorexia, and weight loss. Second, peripheral markers ...

Original Investigation 
Peter Szatmari, MD; Stelios Georgiades, PhD; Eric Duku, PhD; Teresa A. Bennett, MD; Susan Bryson, PhD; Eric Fombonne, MD; Pat Mirenda, PhD; Wendy Roberts, MD; Isabel M. Smith, PhD; Tracy Vaillancourt, PhD; Joanne Volden, PhD; Charlotte Waddell, MD; Lonnie Zwaigenbaum, MD; Mayada Elsabbagh, PhD; Ann Thompson, MS; for the Pathways in ASD Study Team
Includes: Supplemental Content

Importance  Symptom severity and adaptive functioning are fundamental domains of the autism spectrum disorder (ASD) phenotype. To date, the longitudinal association between these 2 domains has not been examined.

Objective  To describe the developmental trajectories of autistic symptom severity and adaptive functioning in a large inception ...

Original Investigation 
Robert H. Pietrzak, PhD, MPH; Yen Ying Lim, PhD; Alexander Neumeister, MD; David Ames, MD; Kathryn A. Ellis, PhD; Karra Harrington, BA; Nicola T. Lautenschlager, MD; Carolina Restrepo, BA; Ralph N. Martins, PhD; Colin L. Masters, MD; Victor L. Villemagne, MD; Christopher C. Rowe, MD; Paul Maruff, PhD; for the Australian Imaging, Biomarkers, and Lifestyle Research Group

Importance  Alzheimer disease (AD) is now known to have a long preclinical phase in which pathophysiologic processes develop many years, even decades, before the onset of clinical symptoms. Although the presence of abnormal levels of amyloid-β (Aβ) is associated with higher rates of progression to clinically classified ...

Viewpoint 
Yuhua Bao, PhD; Yan Tang, MS; Julie Donohue, PhD
This Viewpoint briefly reviews evidence on the range of antidepressant choices needed for depression treatment, examines current antidepressant use patterns in Part D, and assesses how the proposed change would affect the quality of antidepressant treatment in Medicare.
Original Investigation 
Jesse R. Fann, MD, MPH; Charles H. Bombardier, PhD; J. Scott Richards, PhD; Catherine S. Wilson, PsyD; Allen W. Heinemann, PhD; Ann Marie Warren, PhD; Larry Brooks, PhD; Cheryl B. McCullumsmith, MD, PhD; Nancy R. Temkin, PhD; Catherine Warms, PhD; Denise G. Tate, PhD; for the PRISMS Investigators

Importance  Depression is prevalent and associated with negative outcomes in individuals with spinal cord injury (SCI). Antidepressants are used routinely to treat depression, yet no placebo-controlled trials have been published in this population to our knowledge.

Objective  To determine the efficacy and tolerability of venlafaxine hydrochloride ...

Original Investigation 
David P. G. van den Berg, MSc; Paul A. J. M. de Bont, MSc; Berber M. van der Vleugel, MSc; Carlijn de Roos, MSc; Ad de Jongh, PhD; Agnes Van Minnen, PhD; Mark van der Gaag, PhD

Importance  The efficacy of posttraumatic stress disorder (PTSD) treatments in psychosis has not been examined in a randomized clinical trial to our knowledge. Psychosis is an exclusion criterion in most PTSD trials.

Objective  To examine the efficacy and safety of prolonged exposure (PE) therapy and eye ...

Research Letter 
M. Justin Coffey, MD; C. Edward Coffey, MD; Brian K. Ahmedani, PhD
The US Surgeon General and the Institute of Medicine have called for health care systems to help reduce the number of suicides.1,2 However, the few assessments of suicide in such systems have examined specific patient groups rather than the entire population of health plan members.3,4 Here we report, to our ...

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