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Editorial  FREE
John M. Kane, MD; Christoph U. Correll, MD

In this issue of JAMA Psychiatry, the study by Samara et al1 provides an important update on the evidence surrounding clozapine as the treatment of choice for those individuals with schizophrenia that is considered resistant to other medications. The authors indicate that as many as one-third ...

Myrna M. Weissman, PhD

One of the best-replicated findings in clinical psychiatry is that the biological offspring of depressed parents (usually mothers are studied) themselves have considerable emotional and functional problems, usually depression and anxiety. These findings have been shown cross-sectionally in infants1 and in prepubescent, adolescent, and adult offspring.2...

Original Investigation 
Hanyang Shen, MPH, MSc; Cecilia Magnusson, MD, PhD; Dheeraj Rai, MRCPsych, PhD; Michael Lundberg, MPH; Félice Lê-Scherban, PhD; Christina Dalman, MD, PhD; Brian K. Lee, PhD, MHS
Includes: Supplemental Content

Importance  Depression is a common cause of morbidity and disability worldwide. Parental depression is associated with early-life child neurodevelopmental, behavioral, emotional, mental, and social problems. More studies are needed to explore the link between parental depression and long-term child outcomes.

Objective  To examine the associations of ...

Original Investigation  FREE
Myrto T. Samara, MD; Markus Dold, MD; Myrsini Gianatsi, MSc; Adriani Nikolakopoulou, MSc; Bartosz Helfer, MSc; Georgia Salanti, PhD; Stefan Leucht, MD
Includes: Supplemental Content

Importance  In treatment-resistant schizophrenia, clozapine is considered the standard treatment. However, clozapine use has restrictions owing to its many adverse effects. Moreover, an increasing number of randomized clinical trials (RCTs) of other antipsychotics have been published.

Objective  To integrate all the randomized evidence from the available ...

Editorial: Role of Clozapine in Treatment-Resistant Schizophrenia; John M. Kane, MD; Christoph U. Correll, MD
Nora D. Volkow, MD; James M. Swanson, PhD; A. Eden Evins, MD; Lynn E. DeLisi, MD; Madeline H. Meier, PhD; Raul Gonzalez, PhD; Michael A. P. Bloomfield, MRCPsych; H. Valerie Curran, PhD; Ruben Baler, PhD

With a political debate about the potential risks and benefits of cannabis use as a backdrop, the wave of legalization and liberalization initiatives continues to spread. Four states (Colorado, Washington, Oregon, and Alaska) and the District of Columbia have passed laws that legalized cannabis for recreational use by ...

To the Editor In their analysis of the National Health and Nutrition Survey (NHANES), Jokela and colleagues1 address a timely question: Is systemic inflammation more strongly associated with particular depressive symptoms? While C-reactive protein (CRP) was positively associated with all 9 depressive symptoms in separate models, it ...

John R. Blosnich, PhD, MPH; Robert M. Bossarte, PhD

Afifi et al1 corroborate results from a recent US study showing higher prevalence of childhood abuse among persons with a history of military service compared with persons who did not serve in the military.2 More importantly, Afifi and colleagues show how childhood abuse was differentially associated ...

The initial goal of genome-wide association studies (GWASs) of psychiatric disorders was to identify individual genetic variants that predispose to illness. Along the way, another application of GWAS data was discovered1: the polygenic risk score (PRS). The concept is simple. We start with all single-nucleotide polymorphisms ...

Original Investigation 
Andrea J. Gonzalez-Mantilla, MD; Andres Moreno-De-Luca, MD; David H. Ledbetter, PhD; Christa Lese Martin, PhD
Includes: Supplemental Content

Importance  Developmental brain disorders are a group of clinically and genetically heterogeneous disorders characterized by high heritability. Specific highly penetrant genetic causes can often be shared by a subset of individuals with different phenotypic features, and recent advances in genome sequencing have allowed the rapid and cost-effective ...

Original Investigation 
Tracie O. Afifi, PhD; Tamara Taillieu, MSc; Mark A. Zamorski, MD; Sarah Turner, BHSc; Kristene Cheung, MA; Jitender Sareen, MD, FRCPC
Includes: Supplemental Content

Importance  Recent evidence indicates a high prevalence of child abuse exposure in modern US veterans, which may explain in part their higher likelihood of suicide relative to civilians. However, the relationship between child abuse exposure and suicide-related outcomes in military personnel relative to civilians is unknown. Furthermore, ...

Editorial: Childhood Abuse and Military Experience; John R. Blosnich, PhD, MPH; Robert M. Bossarte, PhD
Original Investigation 
Hannah J. Jones, PhD; Evie Stergiakouli, PhD; Katherine E. Tansey, PhD; Leon Hubbard, PhD; Jon Heron, PhD; Mary Cannon, MD, PhD; Peter Holmans, PhD; Glyn Lewis, PhD; David E. J. Linden, DPhil; Peter B. Jones, PhD; George Davey Smith, MD, DSc; Michael C. O’Donovan, PhD, FRCPsych; Michael J. Owen, PhD, FRCPsych; James T. Walters, MRCPsych, PhD; Stanley Zammit, MRCPsych, PhD
Includes: Supplemental Content

Importance  Schizophrenia is a highly heritable, polygenic condition characterized by a relatively diverse phenotype and frequent comorbid conditions, such as anxiety and depression. At present, limited evidence explains how genetic risk for schizophrenia is manifest in the general population.

Objective  To investigate the extent to which ...

Editorial: The Schizophrenia Polygenic Risk Score; Kenneth S. Kendler, MD
Original Investigation 
Sandra M. Meier, PhD; Manuel Mattheisen, MD; Ole Mors, PhD; Diana E. Schendel, PhD; Preben B. Mortensen, DrMedSc; Kerstin J. Plessen, MD, PhD
Includes: Supplemental Content

Importance  Several mental disorders have consistently been found to be associated with decreased life expectancy, but little is known about whether this is also the case for obsessive-compulsive disorder (OCD).

Objective  To determine whether persons who receive a diagnosis of OCD are at increased risk of ...

Charles F. Reynolds III, MD; Ellen Frank, PhD

The US Preventive Services Task Force (USPSTF) has recommended screening for depression in the general adult population, including pregnant and postpartum women, with the use of brief, self-report instruments like the Patient Health Questionnaire 9 that typically take less than 5 minutes to complete. It further underscores the ...

Original Investigation 
Britta Galling, MD; Alexandra Roldán, MD; René E. Nielsen, MD, PhD; Jimmi Nielsen, MD, PhD; Tobias Gerhard, PhD; Maren Carbon, MD; Brendon Stubbs, PhD; Davy Vancampfort, PhD; Marc De Hert, MD, PhD; Mark Olfson, MD, MPH; Kai G. Kahl, MD; Andres Martin, MD; Jeff J. Guo, MD; Hsien-Yuan Lane, MD, PhD; Fung-Chang Sung, PhD, MPH; Chun-Hui Liao, MD; Celso Arango, MD; Christoph U. Correll, MD
Includes: Supplemental Content

Importance  Antipsychotics are used increasingly in youth for nonpsychotic and off-label indications, but cardiometabolic adverse effects and (especially) type 2 diabetes mellitus (T2DM) risk have raised additional concern.

Objective  To assess T2DM risk associated with antipsychotic treatment in youth.

Data Sources  Systematic literature search of ...

Original Investigation 
Ji-Won Hur, PhD; Randolph Blake, PhD; Kang Ik K. Cho, BA; Jejoong Kim, PhD; So-Yeon Kim, PhD; Soo-Hee Choi, MD, PhD; Do-Hyung Kang, MD, PhD; Jun Soo Kwon, MD, PhD
Includes: Supplemental Content

Importance  Exploration of the ability to process socially relevant events portrayed by biological motion and to identify underlying neuronal processes can provide clues for understanding the pathophysiology of psychosis. Individuals with schizotypal personality disorder (SPD) have pervasive interpersonal deficits and odd behaviors. An understanding of the neural ...

Neuroscience and Psychiatry 
John Lisman, PhD

This review reports on what has been learned about the network mechanisms that underlie abnormal delta oscillations.

Patrick McGorry, MD, PhD, FRCP, FRANZCP; Barnaby Nelson, PhD

One of the urgent challenges for psychiatry is to create a simpler, more useful approach to diagnosis.1 Our traditional diagnostic systems are categorical and siloed, consisting of polythetic operational definitions of clinical phenotypes. The boundaries between syndromes and phenotypes are not clear and comorbidity is the rule ...

Original Investigation 
Paolo Fusar-Poli, MD, PhD; Marco Cappucciati, MD; Ilaria Bonoldi, MD; L. M. Christy Hui, PhD; Grazia Rutigliano, MD; Daniel R. Stahl, PhD; Stefan Borgwardt, MD, PhD; Pierluigi Politi, MD, PhD; Aaron L. Mishara, PsyD; Stephen M. Lawrie, MD; William T. Carpenter Jr, MD, PhD; Philip K. McGuire, MD, PhD
Includes: Supplemental Content

Importance  The prognostic significance of competing constructs and operationalizations for brief psychotic episodes (acute and transient psychotic disorder [ATPD], brief psychotic disorder [BPD], brief intermittent psychotic symptoms [BIPS], and brief limited intermittent psychotic symptoms [BLIPS]) is unknown.

Objective  To provide a meta-analytical prognosis of the risk ...

Editorial: Clinical Staging in Emerging Psychotic Illness; Patrick McGorry, MD, PhD, FRCP, FRANZCP; Barnaby Nelson, PhD
Original Investigation 
Shuyang Yao, MSc; Ralf Kuja-Halkola, PhD; Laura M. Thornton, PhD; Cristin D. Runfola, PhD; Brian M. D’Onofrio, PhD; Catarina Almqvist, MD, PhD; Paul Lichtenstein, PhD; Arvid Sjölander, PhD; Henrik Larsson, PhD; Cynthia M. Bulik, PhD
Includes: Supplemental Content

Importance  Suicide attempts are common in individuals with eating disorders. More precise understanding of the mechanisms underlying their concomitant occurrence is needed.

Objective  To examine the association between eating disorders and suicide attempts and whether familial risk factors contribute to the association.

Design, Setting, and Participants...

Comment & Response 
Diana E. Schendel, PhD; Erik Parner, PhD

To the Editor Based on a discordant sibling analysis, Curran et al1 concluded that the elevated risk for autism spectrum disorder (ASD) from cesarean section (CS) was explained by familial factors. Sibling designs are applied to control for unmeasured confounders believed to have a significant influence on ...

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