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 Showing 1-20 of 37 Articles

Mindfulness-based approaches to clinical interventions are receiving increasing attention in psychiatric research.1 The article in this issue of JAMA Psychiatry by Kuyken et al2 is an important meta-analysis of mindfulness-based cognitive therapy (MBCT) in the prevention of depression relapse. This meta-analysis was conducted at the individual ...

Rachel L. Kember, PhD; Maja Bućan, PhD

Bipolar disorder (BD) is a severe mental disorder characterized by alternating periods of depression and mania. It is a highly heritable disorder, and the underlying etiology is thought to be largely genetic, although the identification of specific causal variants has remained challenging. In this issue of JAMA Psychiatry...

Original Investigation  FREE
Willem Kuyken, PhD; Fiona C. Warren, PhD; Rod S. Taylor, PhD; Ben Whalley, PhD; Catherine Crane, PhD; Guido Bondolfi, MD, PhD; Rachel Hayes, PhD; Marloes Huijbers, MSc; Helen Ma, PhD; Susanne Schweizer, PhD; Zindel Segal, PhD; Anne Speckens, MD; John D. Teasdale, PhD; Kees Van Heeringen, PhD; Mark Williams, PhD; Sarah Byford, PhD; Richard Byng, PhD; Tim Dalgleish, PhD
Includes: Supplemental Content

Importance  Relapse prevention in recurrent depression is a significant public health problem, and antidepressants are the current first-line treatment approach. Identifying an equally efficacious nonpharmacological intervention would be an important development.

Objective  To conduct a meta-analysis on individual patient data to examine the efficacy of mindfulness-based ...

Original Investigation 
Fernando S. Goes, MD; Mehdi Pirooznia, MD, PhD; Jennifer S. Parla, PhD; Melissa Kramer, BS; Elena Ghiban, BA; Senem Mavruk, BA; Yun-Ching Chen, PhD; Eric T. Monson, BS; Virginia L. Willour, PhD; Rachel Karchin, PhD; Matthew Flickinger, PhD; Adam E. Locke, PhD; Shawn E. Levy, PhD; Laura J. Scott, PhD; Michael Boehnke, PhD; Eli Stahl, PhD; Jennifer L. Moran, PhD; Christina M. Hultman, PhD; Mikael Landén, MD; Shaun M. Purcell, PhD; Pamela Sklar, MD, PhD; Peter P. Zandi, PhD; W. Richard McCombie, PhD; James B. Potash, MD, MPH
Includes: Supplemental Content

Importance  Complex disorders, such as bipolar disorder (BD), likely result from the influence of both common and rare susceptibility alleles. While common variation has been widely studied, rare variant discovery has only recently become feasible with next-generation sequencing.

Objective  To utilize a combined family-based and case-control ...

Editorial: Promising 2-Pronged Approach to Genetic Basis of Bipolar Disorder; Rachel L. Kember, PhD; Maja Bućan, PhD
Original Investigation 
Babak Hooshmand, MD, PhD, MPH; Francesca Mangialasche, MD, PhD; Grégoria Kalpouzos, PhD; Alina Solomon, MD, PhD; Ingemar Kåreholt, MD, PhD; David Smith, PhD; Helga Refsum, MD, PhD; Rui Wang, PhD; Marc Mühlmann, MD; Birgit Ertl-Wagner, MD; Erika Jonsson Laukka, PhD; Lars Bäckman, PhD; Laura Fratiglioni, MD, PhD; Miia Kivipelto, MD, PhD
Includes: Supplemental Content

Importance  Vitamin B12, folate, and sulfur amino acids may be modifiable risk factors for structural brain changes that precede clinical dementia.

Objective  To investigate the association of circulating levels of vitamin B12, red blood cell folate, and sulfur amino acids with the ...

Natalie Mota, PhD; Robert H. Pietrzak, PhD, MPH; Jitender Sareen, MD

Using data from the US Veterans Health Administration (VHA) from more than 600 000 veterans who served in Iraq or Afghanistan, Brignone et al1 report in this issue of JAMA Psychiatry that a history of military sexual trauma (MST) is independently associated with postdeployment homelessness over a 5-year ...

Andreas Heinz, MD, PhD; Anne Beck, PhD; Michael A. Rapp, MD, PhD

Alcohol is a major environmental hazard, with negative effects on many organs, including the brain, liver, pancreas, and heart.1 It is a leading cause of mortality in industrialized countries.2 Whether the mortality effects of alcohol are due to genetic or environmental effects or a combination of ...

Original Investigation 
Emily Brignone, BS; Adi V. Gundlapalli, MD, PhD, MS; Rebecca K. Blais, PhD; Marjorie E. Carter, MSPH; Ying Suo, MS; Matthew H. Samore, MD; Rachel Kimerling, PhD; Jamison D. Fargo, PhD, MS
Includes: Supplemental Content

Importance  Military sexual trauma (MST) is associated with adverse physical and mental health outcomes following military separation. Recent research suggests that MST may be a determinant in several factors associated with postdeployment homelessness.

Objective  To evaluate MST as an independent risk factor for homelessness and to ...

Editorial: Preventing Veteran Homelessness by Reducing Military Sexual Trauma; Natalie Mota, PhD; Robert H. Pietrzak, PhD, MPH; Jitender Sareen, MD
Original Investigation 
Malin Björnsdotter, MSc, PhD; Nancy Wang; Kevin Pelphrey; Martha D. Kaiser
Includes: Supplemental Content

Importance  Autism spectrum disorder (ASD) is marked by social disability and is associated with dysfunction in brain circuits supporting social cue perception. The degree to which neural functioning reflects individual-level behavioral phenotype is unclear, slowing the search for functional neuroimaging biomarkers of ASD.

Objective  To examine ...

Original Investigation 
Kenneth S. Kendler, MD; Henrik Ohlsson, PhD; Jan Sundquist, MD, PhD; Kristina Sundquist, MD, PhD
Includes: Supplemental Content

Importance  Excess alcohol consumption and alcohol use disorders (AUDs) are associated with substantially increased mortality. Efforts to reduce this toll require an understanding of their causes.

Objective  To clarify the degree to which the excess mortality associated with AUDs arises (1) from the predispositions of the ...

Editorial: Alcohol as An Environmental Mortality Hazard; Andreas Heinz, MD, PhD; Anne Beck, PhD; Michael A. Rapp, MD, PhD
Comment & Response 
Steven D. Hollon, PhD; Robert J. DeRubeis, PhD; Jan Fawcett, MD; Jay D. Amsterdam, MD; Richard C. Shelton, MD; John Zajecka, MD; Paula R. Young, PhD; Robert Gallop, PhD

To the Editor We write to report that we have discovered a number of pervasive errors in our published trial comparing recovery rates for major depressive disorder with cognitive therapy and medication vs medication alone (Effect of Cognitive Therapy With Antidepressant Medications vs Antidepressants Alone on the Rate ...

Health care professionals working with young children are familiar with growth charts. For example, deviation from age-expected values in head circumference triggers an evaluation for underlying disorders. Although it is an invaluable measure, head circumference is nonetheless imperfectly correlated with brain volume and does not reflect brain function. ...

Original Investigation 
Daniel Kessler, BS; Michael Angstadt, MAS; Chandra Sripada, MD, PhD
Includes: Supplemental Content

Importance  Intrinsic connectivity networks (ICNs), important units of brain functional organization, demonstrate substantial maturation during youth. In addition, interrelationships between ICNs have been reliably implicated in attention performance. It is unknown whether alterations in ICN maturational profiles can reliably detect impaired attention functioning in youth.

Objective  ...

Editorial: Brain’s Functional Architecture as Growth Charts; Philip Shaw, BM, BCh, PhD
Original Investigation 
Carolina Montano, BS; Margaret A. Taub, PhD; Andrew Jaffe, PhD; Eirikur Briem, MS; Jason I. Feinberg, BS; Rakel Trygvadottir, BS; Adrian Idrizi, BS; Arni Runarsson, BS; Birna Berndsen, MS; Ruben C. Gur, PhD; Tyler M. Moore, PhD; Rodney T. Perry, PhD; Doug Fugman, PhD; Sarven Sabunciyan, PhD; Robert H. Yolken, MD; Thomas M. Hyde, MD, PhD; Joel E. Kleinman, MD, PhD; Janet L. Sobell, PhD; Carlos N. Pato, MD, PhD; Michele T. Pato, MD; Rodney C. Go, PhD; Vishwajit Nimgaonkar, MD, PhD; Daniel R. Weinberger, MD; David Braff, MD; Raquel E. Gur, MD, PhD; Margaret Daniele Fallin, PhD; Andrew P. Feinberg, MD, MPH
Includes: Supplemental Content

Importance  DNA methylation may play an important role in schizophrenia (SZ), either directly as a mechanism of pathogenesis or as a biomarker of risk.

Objective  To scan genome-wide DNA methylation data to identify differentially methylated CpGs between SZ cases and controls.

Design, Setting, and Participants  ...

Comment & Response 
Jim van Os, MD, PhD

To the Editor We read with interest the findings by Jones et al.1 However, the authors may have overinterpreted the findings. First, correlations between the different dimensions of the Community Assessment of Psychic Experiences (CAPE) (positive, depressive, and negative) typically are in the order of 0.6 to ...

Comment & Response 
Hannah J. Jones, PhD; Stanley Zammit, MRCPsych, PhD

In Reply We thank van Os for his interest in our article.1 We agree that the evidence of association between schizophrenia genetic risk and negative symptoms, but not with psychotic experiences, could be due to greater measurement error when assessing psychotic experiences, as stated in the Discussion ...

Richard S. Schottenfeld, MD; Stephanie S. O’Malley, PhD

In this issue of JAMA Psychiatry, Oviedo-Joekes et al1 report the results of a single-site randomized noninferiority clinical trial in Vancouver, British Columbia, Canada, showing that supervised injection of hydromorphone hydrochloride is not inferior to supervised injection of heroin (diacetylmorphine hydrochloride) in long-term injection street opioid ...

Helen S. Mayberg, MD; Patricio Riva-Posse, MD; Andrea L. Crowell, MD

The article by Bergfeld et al1 in this issue of JAMA Psychiatry reports the results of an investigator-initiated trial of deep brain stimulation (DBS) to the ventral anterior limb of the internal capsule (vALIC) for treatment-resistant depression (TRD). Deep brain stimulation for TRD is an evolving experimental ...

Original Investigation 
Eugenia Oviedo-Joekes, PhD; Daphne Guh, MSc; Suzanne Brissette, MD; Kirsten Marchand, BSc; Scott MacDonald, MD; Kurt Lock, BA; Scott Harrison, MA; Amin Janmohamed, MSc; Aslam H. Anis, PhD; Michael Krausz, MD; David C. Marsh, MD; Martin T. Schechter, MD
Includes: Supplemental Content

Importance  Diacetylmorphine hydrochloride (the active ingredient in heroin), delivered under supervision, is effective for the treatment of severe opioid use disorder. However, owing to political and regulatory barriers, it is not available in many settings around the world, which limits the options for many long-term street opioid ...

Editorial: Meeting the Growing Need for Heroin Addiction Treatment; Richard S. Schottenfeld, MD; Stephanie S. O’Malley, PhD
Original Investigation 
Isidoor O. Bergfeld, MSc; Mariska Mantione, PhD; Mechteld L. C. Hoogendoorn, PhD; Henricus G. Ruhé, MD, PhD; Peter Notten, MD; Jan van Laarhoven, MD; Ieke Visser, MD; Martijn Figee, MD, PhD; Bart P. de Kwaasteniet, MD, PhD; Ferdinand Horst, MSc; Aart H. Schene, MD, PhD; Pepijn van den Munckhof, MD, PhD; Guus Beute, MD; Rick Schuurman, MD, PhD; Damiaan Denys, MD, PhD
Includes: Supplemental Content

Importance  Patients with treatment-resistant depression (TRD) do not respond sufficiently to several consecutive treatments for major depressive disorder. Deep brain stimulation (DBS) is a promising treatment for these patients, but presently placebo effects cannot be ruled out.

Objective  To assess the efficacy of DBS of the ...

Editorial: Deep Brain Stimulation for Depression; Helen S. Mayberg, MD; Patricio Riva-Posse, MD; Andrea L. Crowell, MD

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