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 Showing 1-20 of 38 Articles

Pediatric obsessive-compulsive disorder (OCD) is treated effectively with cognitive behavior therapy (CBT). However, there is clearly room for further improvement, and the exposure strategies used in this treatment are often distressing to patients. Therefore, it is desirable to improve the efficacy of CBT or to accelerate the treatment ...

Editorial  FREE
Harold G. Koenig, MD

According to an April 2016 report from the Centers for Disease Control and Prevention, the suicide rate among white women in the United States increased by 60% from 4.7 per 100 000 in 1999 to 7.5 per 100 000 in 2014.1 The article in this issue of JAMA Psychiatry...

Original Investigation  FREE
Eric A. Storch, PhD; Sabine Wilhelm, PhD; Susan Sprich, PhD; Aude Henin, PhD; Jamie Micco, PhD; Brent J. Small, PhD; Joseph McGuire, PhD; P. Jane Mutch, PhD; Adam B. Lewin, PhD, ABPP; Tanya K. Murphy, MD; Daniel A. Geller, MD
Includes: Supplemental Content

Importance  Cognitive behavior therapy (CBT) among youth with obsessive-compulsive disorder (OCD) is effective, but many patients remain symptomatic after intervention. d-cycloserine, a partial agonist at the N-methyl-d-aspartate receptor in the amygdala, has been associated with enhanced CBT outcome for OCD among adults but ...

Original Investigation  FREE
Tyler J. VanderWeele, PhD; Shanshan Li, ScD; Alexander C. Tsai, MD; Ichiro Kawachi, PhD
Includes: Supplemental Content

Importance  Previous studies have linked suicide risk with religious participation, but the majority have used ecologic, cross-sectional, or case-control data.

Objective  To examine the longitudinal association between religious service attendance and suicide and the joint associations of suicide with service attendance and religious affiliation.

Design, Setting, ...

Editorial: Religious Involvement and Suicide; Harold G. Koenig, MD
Neuroscience and Psychiatry 
Ariel Y. Deutch, PhD

This article discusses advances in the study of corticostriatal circuits and the involvement of these circuits in psychiatric disorders such as schizophrenia.

Original Investigation 
Constance M. Weisner, DrPH, LCSW; Felicia W. Chi, MPH; Yun Lu, MD, MPH; Thekla B. Ross, PsyD; Sabrina B. Wood, BA; Agatha Hinman, BA; David Pating, MD; Derek Satre, PhD; Stacy A. Sterling, DrPH, MSW

Importance  Research has shown that higher activation and engagement with health care is associated with better self-management. To our knowledge, the linkage intervention (LINKAGE) is the first to engage patients receiving addiction treatment with health care using the electronic health record and a patient activation approach.


Research Letter 
Mehmet Burcu, MS; Julie M. Zito, PhD; Leanne Metcalfe, PhD; Howard Underwood, MD, FSA; Daniel J. Safer, MD

This pharmacoepidemiology study uses BCBS claims data to characterize recent trends in use of methylphenidate and amphetamine-related products in 4 US states between 2010 and 2014.

Comment & Response 
Marieke J. H. Begemann, MSc; Sophie M. Heringa, PhD; Iris E. C. Sommer, MD, PhD

To the Editor Mollon and colleagues1 present data from a population-based study evaluating neuropsychological functioning in adults with subclinical psychotic experiences. As rightly noted by the authors,1 previous studies did not adjust for key sociodemographic confounders. Therefore, Mollon et al1 evaluated ethnicity, occupation, cannabis use, ...

Comment & Response 
Josephine Mollon, MSc; Craig Morgan, PhD; Abraham Reichenberg, PhD

In Reply We agree with Begemann and colleagues on the importance of considering relevant environmental factors in studies investigating the association between psychotic experiences and cognition. An association between childhood trauma and risk for later psychosis has been documented.1 Indeed, we found strong evidence in the South ...

Joseph T. Coyle, MD; Glenn Konopaske, MD

Positron emission tomography has been the dominant method for probing the neurochemistry of psychiatric disorders in living humans. This bias reflects the widely held belief that biogenic amines are central to the pathologic processes responsible for serious mental disorders including schizophrenia and affective disorders. Until recently, magnetic resonance ...

Despite the tremendous personal agony and societal burden associated with major depressive disorder (MDD), we have not been able to significantly improve the effectiveness of our treatments for more than 5 decades. Large real-world studies, such as the Sequenced Treatment Alternatives to Relieve Depression (STAR*D),1 have presented ...

Original Investigation 
Kate Merritt, MSc; Alice Egerton, PhD; Matthew J. Kempton, PhD; Matthew J. Taylor, DPhil; Philip K. McGuire, FMedSci
Includes: Supplemental Content

Importance  Alterations in glutamatergic neurotransmission may be fundamental to the pathophysiology of schizophrenia, and the glutamatergic system is a target for novel therapeutic interventions in the disorder.

Objective  To investigate the nature of brain glutamate alterations in schizophrenia by conducting a meta-analysis of glutamate proton magnetic ...

Editorial: Glutamatergic Dysfunction in Schizophrenia; Joseph T. Coyle, MD; Glenn Konopaske, MD
Original Investigation 
Jorge A. Quiroz, MD, MBA; Paul Tamburri, PharmD; Dennis Deptula, PhD; Ludger Banken, PhD; Ulrich Beyer, PhD; Michael Rabbia, MA; Nikhat Parkar, MSc; Paulo Fontoura, MD, PhD; Luca Santarelli, MD
Includes: Supplemental Content

Importance  Antagonism of the postsynaptic metabotropic glutamate subtype 5 receptor is a novel approach to modulate glutamatergic function and has proven efficacy in a number of preclinical behavioral models of depression.

Objective  To evaluate the safety and efficacy of basimglurant modified-release (MR) vs placebo as adjunctive ...

Editorial: Early Glutamate Trials for Major Depressive Disorder; Gerard Sanacora, MD, PhD
Original Investigation 
Luke J. Norman, MSc; Christina Carlisi, BA; Steve Lukito, MSc; Heledd Hart, PhD; David Mataix-Cols, PhD; Joaquim Radua, MD, PhD; Katya Rubia, PhD
Includes: Supplemental Content

Importance  Patients with attention-deficit/hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD) share impaired inhibitory control. However, it is unknown whether impairments are mediated by shared or disorder-specific neurostructural and neurofunctional abnormalities.

Objective  To establish shared and disorder-specific structural, functional, and overlapping multimodal abnormalities in these 2 disorders ...

Original Investigation 
M. Katherine Shear, MD; Charles F. Reynolds III, MD; Naomi M. Simon, MD, MSc; Sidney Zisook, MD; Yuanjia Wang, PhD; Christine Mauro, PhD; Naihua Duan, PhD; Barry Lebowitz, PhD; Natalia Skritskaya, PhD
Includes: Supplemental Content

Importance  To our knowledge, this is the first placebo-controlled randomized clinical trial to evaluate the efficacy of antidepressant pharmacotherapy, with and without complicated grief psychotherapy, in the treatment of complicated grief.

Objective  To confirm the efficacy of a targeted complicated grief treatment (CGT), determine whether citalopram ...

Original Investigation 
Alexander Jarde, PhD; Michelle Morais, MD; Dawn Kingston, PhD; Rebecca Giallo, PhD; Glenda M. MacQueen, MD; Lucy Giglia, MD; Joseph Beyene, PhD; Yi Wang, BHSc; Sarah D. McDonald, MD
Includes: Supplemental Content

Importance  Despite the prevalence of antenatal depression and the fact that only one-third of pregnant women with depression consider it acceptable to take antidepressants, the effect of untreated depression on neonatal outcomes remains to be addressed thoroughly.

Objective  To undertake a systematic review and meta-analysis to ...

Graham Thornicroft, PhD, MSc, MBBS; Claire Henderson, PhD, MSc, MBBS

The article by de Jong et al1 in this issue of JAMA Psychiatry raises fundamental questions about the practice of psychiatry. In essence, the review finds that advance statements can reduce the occurrence of compulsory admissions by approximately one-quarter, while community treatment orders, medication compliance enhancement, and ...

Original Investigation 
Mark H. de Jong, MD; Astrid M. Kamperman, PhD; Margreet Oorschot, PhD; Stefan Priebe, FRCPsych; Wichor Bramer, BSc; Roland van de Sande, PhD; Arthur R. Van Gool, PhD; Cornelis L. Mulder, PhD
Includes: Supplemental Content

Importance  Compulsory admissions, defined as admissions against the will of the patient (according to local judicial procedures), have a strong effect on psychiatric patients. In several Western countries, the rate of such admissions is tending to rise. Its reduction is urgently needed.

Objective  To establish which ...

Editorial: Joint Decision Making and Reduced Compulsory Psychiatric Admissions; Graham Thornicroft, PhD, MSc, MBBS; Claire Henderson, PhD, MSc, MBBS
Original Investigation 
Madeline H. Meier, PhD; Avshalom Caspi, PhD; Magdalena Cerdá, DrPH; Robert J. Hancox, MD; HonaLee Harrington, BA; Renate Houts, PhD; Richie Poulton, PhD; Sandhya Ramrakha, PhD; W. Murray Thomson, PhD; Terrie E. Moffitt, PhD
Includes: Supplemental Content

Importance  After major policy changes in the United States, policymakers, health care professionals, and the general public seek information about whether recreational cannabis use is associated with physical health problems later in life.

Objective  To test associations between cannabis use over 20 years and a variety ...

Comment & Response 
Michael Pascal Hengartner, PhD, MSc

To the Editor In their article in JAMA Psychiatry, Georgakis et al1 report an odds ratio of 0.98 (95% CI, 0.96-0.99) for a 2-year increment in age at menopause in association with depression. I was surprised that the authors attribute this minor effect to estrogen exposure ...

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