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 Showing 1-14 of 14 Articles
Constantine G. Lyketsos, MD, MHS; Matthew E. Peters, MD

It has been known for some time that individuals with schizophrenia develop progressive dementia later in life at higher rates than the general population. Some have argued that this association is a byproduct of the higher rates of chronic medical conditions or addiction in individuals with schizophrenia compared ...

Original Investigation 
Anette Riisgaard Ribe, MD; Thomas Munk Laursen, PhD; Morten Charles, MD, PhD; Wayne Katon, MD†; Morten Fenger-Grøn, MSc; Dimitry Davydow, MD, MPH; Lydia Chwastiak, MD, MPH; Joseph M. Cerimele, MD, MPH; Mogens Vestergaard, MD, PhD
Includes: Supplemental Content

Importance  Although schizophrenia is associated with several age-related disorders and considerable cognitive impairment, it remains unclear whether the risk of dementia is higher among persons with schizophrenia compared with those without schizophrenia.

Objective  To determine the risk of dementia among persons with schizophrenia compared with those ...

Editorial: Dementia in Patients With Schizophrenia: Evidence for Heterogeneity; Constantine G. Lyketsos, MD, MHS; Matthew E. Peters, MD
Original Investigation 
Kathryn Magruder, PhD, MPH; Tracey Serpi, PhD; Rachel Kimerling, PhD; Amy M. Kilbourne, PhD; Joseph F. Collins, ScD; Yasmin Cypel, PhD, MS; Susan M. Frayne, MD, MPH; Joan Furey, RN, MA; Grant D. Huang, MPH, PhD; Theresa Gleason, PhD; Matthew J. Reinhard, PsyD; Avron Spiro, PhD; Han Kang, DrPH
Includes: Supplemental Content

Importance  Many Vietnam-era women veterans served in or near war zones and may have experienced stressful or traumatic events during their service. Although posttraumatic stress disorder (PTSD) is well studied among men who served in Vietnam, no major epidemiologic investigation of PTSD among women has been performed....

Original Investigation 
Karen E. Lythe, PhD; Jorge Moll, MD, PhD; Jennifer A. Gethin, MRes; Clifford I. Workman, BS; Sophie Green, PhD; Matthew A. Lambon Ralph, PhD; John F. W. Deakin, PhD; Roland Zahn, MD
Includes: Supplemental Content

Importance  Patients with remitted major depressive disorder (MDD) were previously found to display abnormal functional magnetic resonance imaging connectivity (fMRI) between the right superior anterior temporal lobe (RSATL) and the subgenual cingulate cortex and adjacent septal region (SCSR) when experiencing self-blaming emotions relative to emotions related to ...

Patricio O’Donnell, MD, PhD; Michael D. Ehlers, MD, PhD

This Viewpoint discusses steps to accelerate innovation and advance new medicines for psychiatric disease.

The article by Peciña and colleagues1 in this issue of JAMA Psychiatry reports the results of a study evaluating with a neuroimaging paradigm the neurochemical mechanisms underlying the formation of placebo effects in patients with major depressive disorder (MDD). Their study involved performing a single-blinded 2-week crossover ...

Original Investigation 
Marta Peciña, MD, PhD; Amy S. B. Bohnert, PhD; Magdalena Sikora, BS; Erich T. Avery, BA; Scott A. Langenecker, PhD; Brian J. Mickey, MD, PhD; Jon-Kar Zubieta, MD, PhD
Includes: Supplemental Content

Importance  High placebo responses have been observed across a wide range of pathologies, severely impacting drug development.

Objective  To examine neurochemical mechanisms underlying the formation of placebo effects in patients with major depressive disorder (MDD).

Design, Setting, and Participants  In this study involving 2 placebo ...

Editorial: Placebo Response in Major Depressive Disorder; Maurizio Fava, MD
Original Investigation 
David A. Brent, MD; Steven M. Brunwasser, PhD; Steven D. Hollon, PhD; V. Robin Weersing, PhD; Gregory N. Clarke, PhD; John F. Dickerson, PhD; William R. Beardslee, MD; Tracy R. G. Gladstone, PhD; Giovanna Porta, MS; Frances L. Lynch, PhD; Satish Iyengar, PhD; Judy Garber, PhD
Includes: Supplemental Content

Importance  Adolescents whose parents have a history of depression are at risk for developing depression and functional impairment. The long-term effects of prevention programs on adolescent depression and functioning are not known.

Objective  To determine whether a cognitive-behavioral prevention (CBP) program reduced the incidence of depressive ...

Original Investigation 
Erica S. Weitz, MA; Steven D. Hollon, PhD; Jos Twisk, PhD; Annemieke van Straten, PhD; Marcus J. H. Huibers, PhD; Daniel David, PhD; Robert J. DeRubeis, PhD; Sona Dimidjian, PhD; Boadie W. Dunlop, MD, MS; Ioana A. Cristea, PhD; Mahbobeh Faramarzi, PhD; Ulrich Hegerl, MD, PhD; Robin B. Jarrett, PhD; Farzan Kheirkhah, MD; Sidney H. Kennedy, MD; Roland Mergl, PhD; Jeanne Miranda, PhD; David C. Mohr, PhD; A. John Rush, MD; Zindel V. Segal, PhD; Juned Siddique, DrPH; Anne D. Simons, PhD; Jeffrey R. Vittengl, PhD; Pim Cuijpers, PhD
Includes: Supplemental Content

Importance  Current guidelines recommend treating severe depression with pharmacotherapy. Randomized clinical trials as well as traditional meta-analyses have considerable limitations in testing for moderators of treatment outcomes.

Objectives  To conduct a systematic literature search, collect primary data from trials, and analyze baseline depression severity as a ...

Comment & Response 
Melissa Raven, PhD

To the Editor The analysis by Walker et al1 of mortality in mental disorders inappropriately generalizes mortality estimates derived from clinical (primarily tertiary) samples, including high proportions of patients with psychotic disorders, to cases identified in population surveys. This markedly exaggerates the population mortality due to mental ...

Comment & Response 
Elizabeth Reisinger Walker, PhD, MPH, MAT; Robin E. McGee, MPH; Benjamin G. Druss, MD, MPH

In Reply Dr Raven highlights the importance of developing accurate population-based estimates of excess mortality among people with mental disorders. She raises several methodological issues that are relevant to developing estimates of disease burden in general and to understanding excess mortality in individuals with mental disorders in particular.

Ian R. H. Rockett, PhD, MPH; Eric D. Caine, MD

This Viewpoint discusses the false dichotomy of separating suicides from fatal self-injurious acts that are labeled “accidents” or “unintentional” deaths.

Sarah N. Garfinkel, PhD; Jessica A. Eccles, MBChB, MRCPsych; Hugo D. Critchley, MBChB, DPhil, FRCPsych, FRSB

Müller and colleagues1 present a study showing that an electroencephalographic signature of the brain’s representation of internal bodily responses (the amplitude of heartbeat evoked potential) is abnormally attenuated in patients with borderline personality disorder (BPD). This deficit predicts symptoms, including the degree of emotional instability, and correlates ...

Original Investigation 
Laura E. Müller, MSc; André Schulz, PhD; Martin Andermann, Dipl-Psych; Andrea Gäbel, PhD; Dorothee Maria Gescher, MD; Angelika Spohn, Dipl-Psych; Sabine C. Herpertz, MD; Katja Bertsch, PhD
Includes: Supplemental Content

Importance  The ability to perceive and regulate one’s own emotions has been tightly linked to the processing of afferent bodily signals (interoception). Thus, disturbed interoception might contribute to the core feature of emotional dysregulation in borderline personality disorder (BPD), as increased levels of depersonalization, body image disturbances, ...

Editorial: The Heart, the Brain, and the Regulation of Emotion; Sarah N. Garfinkel, PhD; Jessica A. Eccles, MBChB, MRCPsych; Hugo D. Critchley, MBChB, DPhil, FRCPsych, FRSB

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