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 Showing 1-19 of 19 Articles
Daphne J. Holt, MD, PhD

Abnormalities in emotional function are thought to play a central role in many of the core symptoms of schizophrenia. However, it has been unexpectedly difficult to pinpoint the changes in emotional processing that occur in the illness. Despite this, it has become increasingly important to make progress on ...

Editorial  FREE
Christopher C. Abbott, MD, MS; Dyani Loo, MD; Jing Sui, PhD

In this issue of JAMA Psychiatry, Redlich et al1 assess the predictive potential of baseline (before electroconvulsive therapy [ECT]) structural neuroimaging with a set of machine-learning–based approaches. In the pre-ECT evaluation and consent process, the ECT health care professional must balance the anticipated benefits and risks for ...

Original Investigation 
Hengyi Cao, MB, MMedSc; Alessandro Bertolino, MD, PhD; Henrik Walter, MD, PhD; Michael Schneider, MD; Axel Schäfer, PhD; Paolo Taurisano, PhD; Giuseppe Blasi, MD, PhD; Leila Haddad, PhD; Oliver Grimm, MD; Kristina Otto, MSc; Luanna Dixson, BSc; Susanne Erk, MD, PhD; Sebastian Mohnke, MSc; Andreas Heinz, MD, PhD; Nina Romanczuk-Seiferth, PhD; Thomas W. Mühleisen, PhD; Manuel Mattheisen, MD; Stephanie H. Witt, PhD; Sven Cichon, PhD; Markus Noethen, MD, PhD; Marcella Rietschel, MD, PhD; Heike Tost, MD, PhD; Andreas Meyer-Lindenberg, MD, PhD
Includes: Supplemental Content

Importance  Although deficits in emotional processing are prominent in schizophrenia, it has been difficult to identify neural mechanisms related to the genetic risk for this highly heritable illness. Prior studies have not found consistent regional activation or connectivity alterations in first-degree relatives compared with healthy controls, suggesting ...

Original Investigation 
Guillermo Horga, MD, PhD; Clifford M. Cassidy, PhD; Xiaoyan Xu, PhD; Holly Moore, PhD; Mark Slifstein, PhD; Jared X. Van Snellenberg, PhD; Anissa Abi-Dargham, MD
Includes: Supplemental Content

Importance  Despite the well-established role of striatal dopamine in psychosis, current views generally agree that cortical dysfunction is likely necessary for the emergence of psychotic symptoms. The topographic organization of striatal-cortical connections is central to gating and integration of higher-order information, so a disruption of such topography ...

Original Investigation  FREE
Ronny Redlich, PhD; Nils Opel, MD; Dominik Grotegerd, MSc; Katharina Dohm, MSc; Dario Zaremba, MSc; Christian Bürger, MSc; Sandra Münker; Lisa Mühlmann, MD; Patricia Wahl, MSc; Walter Heindel, MD; Volker Arolt, MD, PhD; Judith Alferink, MD; Peter Zwanzger, MD, PhD; Maxim Zavorotnyy, MD; Harald Kugel, PhD; Udo Dannlowski, MD, PhD
Includes: Supplemental Content

Importance  Electroconvulsive therapy (ECT) is one of the most effective treatments for severe depression. However, biomarkers that accurately predict a response to ECT remain unidentified.

Objective  To investigate whether certain factors identified by structural magnetic resonance imaging (MRI) techniques are able to predict ECT response.

Design, ...

Editorial: Determining Electroconvulsive Therapy Response; Christopher C. Abbott, MD, MS; Dyani Loo, MD; Jing Sui, PhD
Original Investigation 
Elina Jokiranta-Olkoniemi, MA; Keely Cheslack-Postava, PhD; Dan Sucksdorff, MD; Auli Suominen, MSc; David Gyllenberg, MD, PhD; Roshan Chudal, MD, PhD; Susanna Leivonen, MD; Mika Gissler, PhD; Alan S. Brown, MD, MPH; Andre Sourander, MD, PhD
Includes: Supplemental Content

Importance  Previous research has focused on examining the familial clustering of schizophrenia, bipolar disorder, and autism spectrum disorders (ASD). Little is known about the clustering of other psychiatric and neurodevelopmental disorders among siblings of persons with ASD.

Objective  To examine the risk for psychiatric and neurodevelopmental ...

Mindfulness-based approaches to clinical interventions are receiving increasing attention in psychiatric research.1 The article in this issue of JAMA Psychiatry by Kuyken et al2 is an important meta-analysis of mindfulness-based cognitive therapy (MBCT) in the prevention of depression relapse. This meta-analysis was conducted at the individual ...

Rachel L. Kember, PhD; Maja Bućan, PhD

Bipolar disorder (BD) is a severe mental disorder characterized by alternating periods of depression and mania. It is a highly heritable disorder, and the underlying etiology is thought to be largely genetic, although the identification of specific causal variants has remained challenging. In this issue of JAMA Psychiatry...

Original Investigation 
Willem Kuyken, PhD; Fiona C. Warren, PhD; Rod S. Taylor, PhD; Ben Whalley, PhD; Catherine Crane, PhD; Guido Bondolfi, MD, PhD; Rachel Hayes, PhD; Marloes Huijbers, MSc; Helen Ma, PhD; Susanne Schweizer, PhD; Zindel Segal, PhD; Anne Speckens, MD; John D. Teasdale, PhD; Kees Van Heeringen, PhD; Mark Williams, PhD; Sarah Byford, PhD; Richard Byng, PhD; Tim Dalgleish, PhD
Includes: Supplemental Content

Importance  Relapse prevention in recurrent depression is a significant public health problem, and antidepressants are the current first-line treatment approach. Identifying an equally efficacious nonpharmacological intervention would be an important development.

Objective  To conduct a meta-analysis on individual patient data to examine the efficacy of mindfulness-based ...

Original Investigation 
Fernando S. Goes, MD; Mehdi Pirooznia, MD, PhD; Jennifer S. Parla, PhD; Melissa Kramer, BS; Elena Ghiban, BA; Senem Mavruk, BA; Yun-Ching Chen, PhD; Eric T. Monson, BS; Virginia L. Willour, PhD; Rachel Karchin, PhD; Matthew Flickinger, PhD; Adam E. Locke, PhD; Shawn E. Levy, PhD; Laura J. Scott, PhD; Michael Boehnke, PhD; Eli Stahl, PhD; Jennifer L. Moran, PhD; Christina M. Hultman, PhD; Mikael Landén, MD; Shaun M. Purcell, PhD; Pamela Sklar, MD, PhD; Peter P. Zandi, PhD; W. Richard McCombie, PhD; James B. Potash, MD, MPH
Includes: Supplemental Content

Importance  Complex disorders, such as bipolar disorder (BD), likely result from the influence of both common and rare susceptibility alleles. While common variation has been widely studied, rare variant discovery has only recently become feasible with next-generation sequencing.

Objective  To utilize a combined family-based and case-control ...

Editorial: Promising 2-Pronged Approach to Genetic Basis of Bipolar Disorder; Rachel L. Kember, PhD; Maja Bućan, PhD
Original Investigation 
Babak Hooshmand, MD, PhD, MPH; Francesca Mangialasche, MD, PhD; Grégoria Kalpouzos, PhD; Alina Solomon, MD, PhD; Ingemar Kåreholt, MD, PhD; David Smith, PhD; Helga Refsum, MD, PhD; Rui Wang, PhD; Marc Mühlmann, MD; Birgit Ertl-Wagner, MD; Erika Jonsson Laukka, PhD; Lars Bäckman, PhD; Laura Fratiglioni, MD, PhD; Miia Kivipelto, MD, PhD
Includes: Supplemental Content

Importance  Vitamin B12, folate, and sulfur amino acids may be modifiable risk factors for structural brain changes that precede clinical dementia.

Objective  To investigate the association of circulating levels of vitamin B12, red blood cell folate, and sulfur amino acids with the ...

Natalie Mota, PhD; Robert H. Pietrzak, PhD, MPH; Jitender Sareen, MD

Using data from the US Veterans Health Administration (VHA) from more than 600 000 veterans who served in Iraq or Afghanistan, Brignone et al1 report in this issue of JAMA Psychiatry that a history of military sexual trauma (MST) is independently associated with postdeployment homelessness over a 5-year ...

Andreas Heinz, MD, PhD; Anne Beck, PhD; Michael A. Rapp, MD, PhD

Alcohol is a major environmental hazard, with negative effects on many organs, including the brain, liver, pancreas, and heart.1 It is a leading cause of mortality in industrialized countries.2 Whether the mortality effects of alcohol are due to genetic or environmental effects or a combination of ...

Original Investigation 
Emily Brignone, BS; Adi V. Gundlapalli, MD, PhD, MS; Rebecca K. Blais, PhD; Marjorie E. Carter, MSPH; Ying Suo, MS; Matthew H. Samore, MD; Rachel Kimerling, PhD; Jamison D. Fargo, PhD, MS
Includes: Supplemental Content

Importance  Military sexual trauma (MST) is associated with adverse physical and mental health outcomes following military separation. Recent research suggests that MST may be a determinant in several factors associated with postdeployment homelessness.

Objective  To evaluate MST as an independent risk factor for homelessness and to ...

Editorial: Preventing Veteran Homelessness by Reducing Military Sexual Trauma; Natalie Mota, PhD; Robert H. Pietrzak, PhD, MPH; Jitender Sareen, MD
Original Investigation 
Malin Björnsdotter, MSc, PhD; Nancy Wang; Kevin Pelphrey; Martha D. Kaiser
Includes: Supplemental Content

Importance  Autism spectrum disorder (ASD) is marked by social disability and is associated with dysfunction in brain circuits supporting social cue perception. The degree to which neural functioning reflects individual-level behavioral phenotype is unclear, slowing the search for functional neuroimaging biomarkers of ASD.

Objective  To examine ...

Original Investigation 
Kenneth S. Kendler, MD; Henrik Ohlsson, PhD; Jan Sundquist, MD, PhD; Kristina Sundquist, MD, PhD
Includes: Supplemental Content

Importance  Excess alcohol consumption and alcohol use disorders (AUDs) are associated with substantially increased mortality. Efforts to reduce this toll require an understanding of their causes.

Objective  To clarify the degree to which the excess mortality associated with AUDs arises (1) from the predispositions of the ...

Editorial: Alcohol as An Environmental Mortality Hazard; Andreas Heinz, MD, PhD; Anne Beck, PhD; Michael A. Rapp, MD, PhD
Comment & Response 
Steven D. Hollon, PhD; Robert J. DeRubeis, PhD; Jan Fawcett, MD; Jay D. Amsterdam, MD; Richard C. Shelton, MD; John Zajecka, MD; Paula R. Young, PhD; Robert Gallop, PhD

To the Editor We write to report that we have discovered a number of pervasive errors in our published trial comparing recovery rates for major depressive disorder with cognitive therapy and medication vs medication alone (Effect of Cognitive Therapy With Antidepressant Medications vs Antidepressants Alone on the Rate ...

Comment & Response 
Jim van Os, MD, PhD

To the Editor We read with interest the findings by Jones et al.1 However, the authors may have overinterpreted the findings. First, correlations between the different dimensions of the Community Assessment of Psychic Experiences (CAPE) (positive, depressive, and negative) typically are in the order of 0.6 to ...

Comment & Response 
Hannah J. Jones, PhD; Stanley Zammit, MRCPsych, PhD

In Reply We thank van Os for his interest in our article.1 We agree that the evidence of association between schizophrenia genetic risk and negative symptoms, but not with psychotic experiences, could be due to greater measurement error when assessing psychotic experiences, as stated in the Discussion ...

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