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 Showing 1-20 of 28 Articles
Editorial  FREE
Christopher J. McDougle, MD

In this issue of JAMA Psychiatry, Anagnostou et al1 present results of a double-blind, placebo-controlled study of metformin for weight management in children and adolescents with autism spectrum disorder (ASD) treated with an atypical antipsychotic medication. Metformin was significantly more efficacious than the placebo for decreasing weight ...

Original Investigation  FREE
Evdokia Anagnostou, MD; Michael G. Aman, PhD; Benjamin L. Handen, PhD; Kevin B. Sanders, MD; Amy Shui, MA; Jill A. Hollway, PhD; Jessica Brian, PhD; L. Eugene Arnold, MD; Lucia Capano, MD; Jessica A. Hellings, MD; Eric Butter, PhD; Deepali Mankad, MD; Rameshwari Tumuluru, MD; Jessica Kettel, MD; Cassandra R. Newsom, PsyD; Stasia Hadjiyannakis, MD; Naomi Peleg, MSc; Dina Odrobina, BMSc; Sarah McAuliffe-Bellin, MEd; Pearl Zakroysky, MPH; Sarah Marler, MA; Alexis Wagner, BS; Taylor Wong, BS; Eric A. Macklin, PhD; Jeremy Veenstra-VanderWeele, MD
Includes: Supplemental Content

Importance  Atypical antipsychotic medications are indicated for the treatment of irritability and agitation symptoms in children with autism spectrum disorder (ASD). Unfortunately, these medications are associated with weight gain and metabolic complications that are especially troubling in children and with long-term use.

Objective  To evaluate the ...

Editorial: Atypical Antipsychotic-Induced Weight Gain in Youths; Christopher J. McDougle, MD
Original Investigation 
Ian R. H. Rockett, PhD, MPH; Christa L. Lilly, PhD; Haomiao Jia, PhD; Gregory L. Larkin, MD, MSPH; Ted R. Miller, PhD; Lewis S. Nelson, MD; Kurt B. Nolte, MD; Sandra L. Putnam, PhD; Gordon S. Smith, MD, MPH; Eric D. Caine, MD

Importance  Fatal self-injury in the United States associated with deliberate behaviors is seriously underestimated owing to misclassification of poisoning suicides and mischaracterization of most drug poisoning deaths as “accidents” on death certificates.

Objective  To compare national trends and patterns of self-injury mortality (SIM) with mortality from ...

Megan C. Lytle, PhD; Vincent M. B. Silenzio, MD, MPH; Eric D. Caine, MD

This Viewpoint addresses suicide prevention in the context of successful lay-led disease advocacy efforts.

Katherine L. Wisner, MD, MS; Hyunyoung Jeong, PharmD, PhD; Christina Chambers, PhD, MPH

The blunt subtitle focuses attention on the pregnant woman as “the last true therapeutic orphan.”1(p227) Because of ethical, medicolegal, and fetal safety concerns, they have been excluded from treatment studies. Pregnant women constitute a disadvantaged population that has been “protected” from participation in research, only to ...

Child maltreatment is a debilitating problem and a global public health issue.1 According to the World Health Organization, 1 in 4 adults report having been physically maltreated and 1 in 5 women disclose having been sexually abused in childhood. The extent of the problem is even larger ...

Original Investigation 
Krista F. Huybrechts, MS, PhD; Sonia Hernández-Díaz, MD, DrPH; Elisabetta Patorno, MD, DrPH; Rishi J. Desai, PhD; Helen Mogun, MS; Sara Z. Dejene, BS; Jacqueline M. Cohen, PhD; Alice Panchaud, PhD; Lee Cohen, MD; Brian T. Bateman, MD, MSc
Includes: Supplemental Content

Importance  The frequency of antipsychotic (AP) use during pregnancy has approximately doubled during the last decade. However, little is known about their safety for the developing fetus, and concerns have been raised about a potential association with congenital malformations.

Objective  To examine the risk for congenital ...

Editorial: Use of Antipsychotics During Pregnancy; Katherine L. Wisner, MD, MS; Hyunyoung Jeong, PharmD, PhD; Christina Chambers, PhD, MPH
Original Investigation 
Edith Chen, PhD; Nicholas A. Turiano, PhD; Daniel K. Mroczek, PhD; Gregory E. Miller, PhD
Includes: Supplemental Content

Importance  Research has linked childhood abuse to a variety of adult psychiatric problems, but little is known about associations of child abuse with adult mortality.

Objective  To test associations of retrospective reports of physical and emotional abuse in childhood with all-cause mortality rates in adulthood.

Design, ...

Editorial: Child Maltreatment and Mortality Disparities; Idan Shalev, PhD; Christine M. Heim, PhD; Jennie G. Noll, PhD
Original Investigation 
Maria Panagioti, PhD; Peter Bower, PhD; Evangelos Kontopantelis, PhD; Karina Lovell, PhD; Simon Gilbody, DPhil; Waquas Waheed, MD; Chris Dickens, PhD; Janine Archer, PhD; Gregory Simon, MD; Kathleen Ell, PhD; Jeff C. Huffman, MD; David A. Richards, PhD; Christina van der Feltz-Cornelis, MD; David A. Adler, MD; Martha Bruce, PhD; Marta Buszewicz, MD; Martin G. Cole, MD; Karina W. Davidson, PhD; Peter de Jonge, PhD; Jochen Gensichen, MD; Klaas Huijbregts, PhD; Marco Menchetti, MD; Vikram Patel, PhD; Bruce Rollman, PhD; Jonathan Shaffer, PhD; Moniek C. Zijlstra-Vlasveld, PhD; Peter A. Coventry, PhD
Includes: Supplemental Content

Importance  Collaborative care is an intensive care model involving several health care professionals working together, typically a physician, a case manager, and a mental health professional. Meta-analyses of aggregate data have shown that collaborative care is particularly effective in people with depression and comorbid chronic physical conditions. ...

Original Investigation 
Elliott Rees, PhD; Kimberley Kendall, MBBCh; Antonio F. Pardiñas, PhD; Sophie E. Legge, PhD; Andrew Pocklington, PhD; Valentina Escott-Price, PhD; James H. MacCabe, PhD, MRCPsych; David A. Collier, PhD; Peter Holmans, PhD; Michael C. O’Donovan, PhD, FRCPsych; Michael J. Owen, PhD, FRCPsych; James T. R. Walters, MRCPsych, PhD; George Kirov, PhD, MRCPsych
Includes: Supplemental Content

Importance  At least 11 rare copy number variants (CNVs) have been shown to be major risk factors for schizophrenia (SZ). These CNVs also increase the risk for other neurodevelopmental disorders, such as intellectual disability. It is possible that additional intellectual disability–associated CNVs increase the risk for SZ ...

Comment & Response 
Marij Zuidersma, PhD; Richard C. Oude Voshaar, MD, PhD

To the Editor It is often debated whether depression is a risk factor for dementia, whether it is a prodromal state of dementia, or whether depression and dementia share a common underlying pathology, with evidence supporting all these hypotheses. With interest, we read the study of Kaup et ...

Lena C. Brundin, MD, PhD; Jamie Grit, BSc

Mounting evidence points to an up-regulated inflammatory response in patients who experience suicidal ideation, attempt, or commit suicide. Translational and clinical studies are now disentangling the neurobiological mechanisms that generate the symptoms in inflammation-induced depression. But what are the actual causes of the low-grade, long-term inflammation that is ...

Topics: infection; suicide
Original Investigation 
Myrna M. Weissman, PhD; Obianuju O. Berry, MD, MPH; Virginia Warner, DrPH; Marc J. Gameroff, PhD; Jamie Skipper, MS; Ardesheer Talati, PhD; Daniel J. Pilowsky, MD, MPH; Priya Wickramaratne, PhD
Includes: Supplemental Content

Importance  The increased risk of major depression in the offspring of depressed parents is well known. Whether the risk is transmitted beyond 2 generations is less well known. To our knowledge, no published study with direct interviews of family members and the generations in the age of ...

Original Investigation 
Helene Lund-Sørensen, BM; Michael E. Benros, PhD; Trine Madsen, PhD; Holger J. Sørensen, MD; William W. Eaton, PhD; Teodor T. Postolache, MD; Merete Nordentoft, DrMedSc; Annette Erlangsen, PhD
Includes: Supplemental Content

Importance  Findings suggest that infections might be linked to the development of psychiatric disorders and suicidal behavior. Large-scale studies are needed to investigate the effect of infection on the risk of suicide.

Objective  To estimate the association between hospitalization with infection and the risk of death ...

Topics: infection; suicide
Editorial: Ascertaining Whether Suicides Are Caused by Infections; Lena C. Brundin, MD, PhD; Jamie Grit, BSc
Research Letter 
G. David Batty, DSc; Steven Bell, PhD; Emmanuel Stamatakis, PhD; Mika Kivimäki, PhD

This study uses UK national survey data to investigate the association between C-reactive protein levels and risk of suicide.

Allan A. Abbass, MD, FRCPC; Joel M. Town, DClinPsy

This Editorial discusses the effectiveness of short-term psychodynamic psychotherapy for major depressive disorder.

Original Investigation 
Anouk Schrantee, MSc; Hyke G. H. Tamminga, MSc; Cheima Bouziane, MSc; Marco A. Bottelier, MD; Esther E. Bron, MSc; Henk-Jan M. M. Mutsaerts, MD, PhD; Aeilko H. Zwinderman, PhD; Inge R. Groote, PhD; Serge A. R. B. Rombouts, PhD; Ramon J. L. Lindauer, MD, PhD; Stefan Klein, PhD; Wiro J. Niessen, PhD; Brent C. Opmeer, PhD; Frits Boer, MD, PhD; Paul J. Lucassen, PhD; Susan L. Andersen, PhD; Hilde M. Geurts, PhD; Liesbeth Reneman, MD, PhD
Includes: Supplemental Content

Importance  Although numerous children receive methylphenidate hydrochloride for the treatment of attention-deficit/hyperactivity disorder (ADHD), little is known about age-dependent and possibly lasting effects of methylphenidate on the human dopaminergic system.

Objectives  To determine whether the effects of methylphenidate on the dopaminergic system are modified by age ...

Original Investigation 
Mary Beth Connolly Gibbons, PhD; Robert Gallop, PhD; Donald Thompson, PhD; Debra Luther, PhD; Kathryn Crits-Christoph, PhD; Julie Jacobs, PhD; Seohyun Yin, BA; Paul Crits-Christoph, PhD
Includes: Supplemental Content

Importance  Dynamic psychotherapy (DT) is widely practiced in the community, but few trials have established its effectiveness for specific mental health disorders relative to control conditions or other evidence-based psychotherapies.

Objective  To determine whether DT is not inferior to cognitive therapy (CT) in the treatment of ...

Editorial: Effectiveness of Brief Psychotherapies for Depression; Allan A. Abbass, MD, FRCPC; Joel M. Town, DClinPsy
Stuart B. Murray, PhD; Katharine L. Loeb, PhD; Daniel Le Grange, PhD

This Viewpoint argues that individualized exposure therapy distinguishing between fear of food vs weight gain is important for successful management of anorexia nervosa.

Original Investigation 
Maria A. Oquendo, MD; Hanga Galfalvy, PhD; Gregory M. Sullivan, MD; Jeffrey M. Miller, MD; Matthew M. Milak, MD; M. Elizabeth Sublette, MD, PhD; Sebastian Cisneros-Trujillo, MD; Ainsley K. Burke, PhD; Ramin V. Parsey, MD, PhD; J. John Mann, MD
Includes: Supplemental Content

Importance  Biomarkers that predict suicidal behavior, especially highly lethal behavior, are urgently needed. In cross-sectional studies, individuals with depression who attempt suicide have lower midbrain serotonin transporter binding potential compared with those who do not attempt suicide, and higher serotonin1A binding potential in the raphe nuclei ...

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