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Basic View | Expanded View
 Showing 1-20 of 32 Articles
Original Investigation  FREE
Craig Rodriguez-Seijas, BSc; Malki Stohl, MS; Deborah S. Hasin, PhD; Nicholas R. Eaton, PhD
Includes: Supplemental Content

Importance  Multivariable comorbidity research indicates that many common mental disorders are manifestations of 2 latent transdiagnostic factors, internalizing and externalizing. Environmental stressors are known to increase the risk for experiencing particular mental disorders, but their relationships with transdiagnostic disorder constructs are unknown. The present study investigated one ...

Research Letter 
Matthew J. Kempton, MSc, PhD; Ilaria Bonoldi, MD; Lucia Valmaggia, PhD; Philip McGuire, MBChB, MD, PhD, FRCPsych, FMedSci; Paolo Fusar-Poli, MD, PhD, RCPsych
This meta-analysis discusses the speed of psychosis progression in patients at ultra-high risk.
Original Investigation  FREE
Frances R. Levin, MD; John J. Mariani, MD; Sheila Specker, MD; Marc Mooney, PhD; Amy Mahony, LMHC; Daniel J. Brooks, MA; David Babb, BA; Yun Bai, MS; Lynn E. Eberly, PhD; Edward V. Nunes, MD; John Grabowski, PhD
Includes: Supplemental Content

Importance  Adult attention-deficit/hyperactivity disorder (ADHD) is prevalent but often unrecognized, in part because it tends to co-occur with other disorders such as substance use disorders. Cocaine use disorder is one such disorder with high co-occurrence of ADHD.

Objective  To examine whether treatment of co-occurring ADHD and ...

Original Investigation  FREE
Wayne Katon, MD†; Henrik Sondergaard Pedersen, MSc; Anette Riisgaard Ribe, MD; Morten Fenger-Grøn, MSc; Dimitry Davydow, MD, MPH; Frans Boch Waldorff, MD, PhD; Mogens Vestergaard, MD, PhD
Includes: Supplemental Content

Importance  Although depression and type 2 diabetes mellitus (DM) may independently increase the risk for dementia, no studies have examined whether the risk for dementia among people with comorbid depression and DM is higher than the sum of each exposure individually.

Objective  To examine the risk ...

Invited Commentary: Healthy Brain Aging; Charles F. Reynolds III, MD
Invited Commentary 
Charles F. Reynolds III, MD
The co-occurrence of diabetes mellitus and depression, especially in persons younger than 65 years, poses an important hazard to healthy brain aging and cognitive fitness in the later years of life. Katon and colleagues1 from Denmark contribute this key observation in this issue of JAMA Psychiatry.
Viewpoint 
Andrew H. Miller, MD; Charles L. Raison, MD
This Viewpoint reports on the accumulating data indicating that inflammation may play a role in a host of psychiatric illnesses.
Original Investigation 
Yuzheng Hu, PhD; Betty Jo Salmeron, MD; Hong Gu, PhD; Elliot A. Stein, PhD; Yihong Yang, PhD
Includes: Supplemental Content

Importance  Converging evidence has long identified both impulsivity and compulsivity as key psychological constructs in drug addiction. Although dysregulated striatal-cortical network interactions have been identified in cocaine addiction, the association between these brain networks and addiction is poorly understood.

Objectives  To test the hypothesis that cocaine ...

Original Investigation 
Addie Weaver, PhD; Joseph A. Himle, PhD; Robert Joseph Taylor, PhD; Niki N. Matusko, MA; Jamie M. Abelson, MSW

Importance  There is a paucity of research among African Americans and rural residents. Little is known about the association between urbanicity and depression or about the interaction of urbanicity, race/ethnicity, and sex on depression and mood disorder prevalence.

Objective  To examine the interaction of urbanicity and ...

Original Investigation 
Sophia Mueller, MD; Danhong Wang, MD; Ruiqi Pan, BS; Daphne J. Holt, MD, PhD; Hesheng Liu, PhD
Includes: Supplemental Content

Importance  Hemispheric specialization of the human brain is a marker of successful neurodevelopment. Altered brain asymmetry that has been repeatedly reported in schizophrenia may represent consequences of disrupted neurodevelopment in the disorder. However, a complete picture of functional specialization in the schizophrenic brain and its connectional substrates ...

Original Investigation 
Yaron Finkelstein, MD, ABCP(Dip); Erin M. Macdonald, MSc; Simon Hollands, MSc; Marco L. A. Sivilotti, MD, MSc; Janine R. Hutson, MD, PhD; Muhammad M. Mamdani, PharmD, MA, MPH; Gideon Koren, MD; David N. Juurlink, MD, PhD; for the Canadian Drug Safety and Effectiveness Research Network (CDSERN)
Includes: Supplemental Content

Importance  Suicide is the tenth leading cause of death in the United States, and its rate has risen by 16% in the past decade. Deliberate self-poisoning is the leading method of attempted suicide. Unlike more violent methods, which are almost universally fatal, survival following self-poisoning is common, ...

Original Investigation 
Mark A. Reger, PhD; Derek J. Smolenski, MPH, PhD; Nancy A. Skopp, PhD; Melinda J. Metzger-Abamukang, BS; Han K. Kang, DrPH; Tim A. Bullman, MA; Sondra Perdue, DrPH; Gregory A. Gahm, PhD

Importance  A pressing question in military suicide prevention research is whether deployment in support of Operation Enduring Freedom or Operation Iraqi Freedom relates to suicide risk. Prior smaller studies report differing results and often have not included suicides that occurred after separation from military service.

Objective  ...

Original Investigation  FREE
Esben Agerbo, DrMedSc; Patrick F. Sullivan, FRANZCP; Bjarni J. Vilhjálmsson, PhD; Carsten B. Pedersen, DrMedSc; Ole Mors, PhD; Anders D. Børglum, PhD; David M. Hougaard, DrMedSc; Mads V. Hollegaard, PhD; Sandra Meier, PhD; Manuel Mattheisen, PhD; Stephan Ripke, MD; Naomi R. Wray, PhD; Preben B. Mortensen, DrMedSc
Includes: Supplemental Content

Importance  Schizophrenia has a complex etiology influenced both by genetic and nongenetic factors but disentangling these factors is difficult.

Objective  To estimate (1) how strongly the risk for schizophrenia relates to the mutual effect of the polygenic risk score, parental socioeconomic status, and family history of ...

Comment & Response 
Vladan Starcevic, MD, PhD, FRANZCP
To the Editor In an article, Olfson et al1 reported higher rates of long-term benzodiazepine use among older adults in the United States. They assumed that benzodiazepines are prescribed to older individuals mainly for insomnia and anxiety and stated alarmingly that “most physicians do not view continuous use of benzodiazepines ...
Comment & Response 
Mark Olfson, MD, MPH; Marissa King, PhD; Michael Schoenbaum, PhD
In Reply Dr Starcevic questions whether long-term benzodiazepine use poses health risks to older adults. He suggests that for older adults, long-term use of benzodiazepines does not increase the risk for fractures, is much safer than antidepressants, and generally maintains its clinical effectiveness over time.
Original Investigation 
Joris Berwaerts, MD; Yanning Liu, MS; Srihari Gopal, MD, MHS; Isaac Nuamah, PhD; Haiyan Xu, PhD; Adam Savitz, MD, PhD; Danielle Coppola, MD; Alain Schotte, PhD; Bart Remmerie, Chem Eng; Nataliya Maruta, MD, PhD; David W. Hough, MD
Includes: Supplemental Content

Importance  Treatment nonadherence and relapse are common problems in patients with schizophrenia. The long-acting 3-month formulation of paliperidone palmitate, owing to its extended elimination half-life, may offer a valuable therapeutic option for these patients.

Objective  To evaluate the efficacy and safety of the 3-month formulation of ...

Original Investigation 
Michaeline Bresnahan, PhD, MPH; Mady Hornig, MD; Andrew F. Schultz, MS; Nina Gunnes, PhD; Deborah Hirtz, MD; Kari Kveim Lie, MD; Per Magnus, MD, PhD; Ted Reichborn-Kjennerud, MD, PhD; Christine Roth, PhD; Synnve Schjølberg, LPsy; Camilla Stoltenberg, MD, PhD; Pål Surén, MD, MPH; Ezra Susser, MD, DrPH; W. Ian Lipkin, MD
Includes: Supplemental Content

Importance  Gastrointestinal (GI) comorbidities are frequently described in association with autism spectrum disorder (ASD). However, the prevalence of GI disturbances and the age at which such problems first appear are unclear, and their specificity for ASD compared with other neurodevelopmental disorders is uncertain.

Objective  To compare ...

Original Investigation 
Marsha M. Linehan, PhD; Kathryn E. Korslund, PhD; Melanie S. Harned, PhD; Robert J. Gallop, PhD; Anita Lungu, PhD; Andrada D. Neacsiu, PhD; Joshua McDavid, MD; Katherine Anne Comtois, PhD; Angela M. Murray-Gregory, MSW
Includes: Supplemental Content

Importance  Dialectical behavior therapy (DBT) is an empirically supported treatment for suicidal individuals. However, DBT consists of multiple components, including individual therapy, skills training, telephone coaching, and a therapist consultation team, and little is known about which components are needed to achieve positive outcomes.

Objective  To ...

Original Investigation 
Jean-Paul Selten, MD, PhD; Michael Lundberg, MPH; Dheeraj Rai, MRCPsych, PhD; Cecilia Magnusson, MD, PhD
Includes: Supplemental Content

Importance  Whether individuals with autism spectrum disorder (ASD) are at increased risk for nonaffective psychotic disorder (NAPD) or bipolar disorder (BD) is unknown.

Objective  To test whether the risks for NAPD and BD in individuals with ASD are increased and whether these risks are higher than ...

Original Investigation 
Annelieke M. Roest, PhD; Peter de Jonge, PhD; Craig D. Williams, PharmD; Ymkje Anna de Vries, MSc; Robert A. Schoevers, MD, PhD; Erick H. Turner, MD
Includes: Supplemental Content

Importance  Studies have shown that the scientific literature has overestimated the efficacy of antidepressants for depression, but other indications for these drugs have not been considered.

Objective  To examine reporting biases in double-blind, placebo-controlled trials on the pharmacologic treatment of anxiety disorders and quantify the extent ...

Original Investigation 
Bradley S. Peterson, MD; Virginia A. Rauh, ScD; Ravi Bansal, PhD; Xuejun Hao, PhD; Zachary Toth, BA; Giancarlo Nati, BA; Kirwan Walsh, BA; Rachel L. Miller, MD; David Semanek, BA; Frederica Perera, DrPH, PhD
Includes: Supplemental Content

Importance  Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous and neurotoxic environmental contaminants. Prenatal PAH exposure is associated with subsequent cognitive and behavioral disturbances in childhood.

Objectives  To identify the effects of prenatal PAH exposure on brain structure and to assess the cognitive and behavioral correlates of those ...

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