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 Showing 1-20 of 29 Articles
David Goldman, MD

Cannabis is widely used, psychoactive, and addictive. Given the choice, people in several US states and the District of Columbia have voted to legalize it. In the nation’s capital, it is now legal to possess as many as 3 Cannabis sativa plants. Meanwhile, it remains illegal to have ...

Original Investigation  FREE
David Pagliaccio, PhD; Deanna M. Barch, PhD; Ryan Bogdan, PhD; Phillip K. Wood, PhD; Michael T. Lynskey, PhD; Andrew C. Heath, DPhil; Arpana Agrawal, PhD
Includes: Supplemental Content

Importance  Prior neuroimaging studies have suggested that alterations in brain structure may be a consequence of cannabis use. Siblings discordant for cannabis use offer an opportunity to use cross-sectional data to disentangle such causal hypotheses from shared effects of genetics and familial environment on brain structure and ...

Editorial: America’s Cannabis Experiment; David Goldman, MD
Original Investigation 
Leon French, PhD; Courtney Gray, MSc; Gabriel Leonard, PhD; Michel Perron, PhD; G. Bruce Pike, PhD; Louis Richer, PhD; Jean R. Séguin, PhD; Suzanne Veillette, PhD; C. John Evans, PhD; Eric Artiges, MD, PhD; Tobias Banaschewski, MD, PhD; Arun W. L. Bokde, PhD; Uli Bromberg, PhD; Ruediger Bruehl, PhD; Christian Buchel, MD; Anna Cattrell, PhD; Patricia J. Conrod, PhD; Herta Flor, PhD; Vincent Frouin, PhD; Jurgen Gallinat, MD; Hugh Garavan, PhD; Penny Gowland, PhD; Andreas Heinz, MD; Herve Lemaitre, PhD; Jean-Luc Martinot, MD; Frauke Nees, PhD; Dimitri Papadopoulos Orfanos, PhD; Melissa Marie Pangelinan, PhD; Luise Poustka, MD; Marcella Rietschel, MD; Michael N. Smolka, PhD; Henrik Walter, MD; Robert Whelan, PhD; Nic J. Timpson, PhD; Gunter Schumann, MD; George Davey Smith, MD, DSc; Zdenka Pausova, MD; Tomáš Paus, MD, PhD
Includes: Supplemental Content

Importance  Cannabis use during adolescence is known to increase the risk for schizophrenia in men. Sex differences in the dynamics of brain maturation during adolescence may be of particular importance with regard to vulnerability of the male brain to cannabis exposure.

Objective  To evaluate whether the ...

Editorial: America’s Cannabis Experiment; David Goldman, MD
Original Investigation  FREE
Stephen F. Smagula, PhD; Meryl A. Butters, PhD; Stewart J. Anderson, PhD; Eric J. Lenze, MD; Mary Amanda Dew, PhD; Benoit H. Mulsant, MD; Francis E. Lotrich, MD, PhD; Howard Aizenstein, MD, PhD; Charles F. Reynolds III, MD
Includes: Supplemental Content

Importance  More than 50% of older adults with late-life major depressive disorder fail to respond to initial treatment with first-line pharmacological therapy.

Objectives  To assess typical patterns of response to an open-label trial of extended-release venlafaxine hydrochloride (venlafaxine XR) for late-life depression and to evaluate which ...

Comment & Response 
Roberto Lozano, PhD

To the Editor In their article, Maust et al1 concluded that the absolute effect of antipsychotics on mortality in elderly patients with dementia may be higher than previously reported. To assess this, they compared the estimated mortality risk associated with each antipsychotic agent (eg, haloperidol, risperidone, olanzapine, ...

Comment & Response 
Donovan T. Maust, MD, MS; Lon S. Schneider, MD, MS; Helen C. Kales, MD

In Reply Dr Lozano suggests that in our article,1 we failed to take into account the variation in depression prevalence between the various medication user groups and matched nonusers and that our findings were therefore biased.

Bronwyn M. Graham, PhD/MPsychol(Clin); Rick Richardson, PhD

This Viewpoint discusses the use of fibroblast growth factor 2 as an adjunct for treating anxiety.

Original Investigation  FREE
Alan Anticevic, PhD; Kristen Haut, PhD; John D. Murray, PhD; Grega Repovs, PhD; Genevieve J. Yang, BS; Caroline Diehl, BS; Sarah C. McEwen, PhD; Carrie E. Bearden, PhD; Jean Addington, PhD; Bradley Goodyear, PhD; Kristin S. Cadenhead, MD; Heline Mirzakhanian, PhD; Barbara A. Cornblatt, PhD, MBA; Doreen Olvet, PhD; Daniel H. Mathalon, MD, PhD; Thomas H. McGlashan, MD; Diana O. Perkins, MD; Aysenil Belger, PhD; Larry J. Seidman, PhD; Ming T. Tsuang, MD, PhD, DSc; Theo G. M. van Erp, PhD; Elaine F. Walker, PhD; Stephan Hamann, PhD; Scott W. Woods, MD; Maolin Qiu, PhD; Tyrone D. Cannon, PhD
Includes: Supplemental Content

Importance  Severe neuropsychiatric conditions, such as schizophrenia, affect distributed neural computations. One candidate system profoundly altered in chronic schizophrenia involves the thalamocortical networks. It is widely acknowledged that schizophrenia is a neurodevelopmental disorder that likely affects the brain before onset of clinical symptoms. However, no investigation has ...

Editorial: Search for the Koplik Spots of Psychosis; Paolo Fusar-Poli, MD, PhD, RCPsych
Helena Chmura Kraemer, PhD

Concern about erroneous conclusions of many published research findings has led to the conclusion that most published research findings are wrong.1,2 What can be done about that? In what follows, I will focus on one common source of false findings: adjusting for covariates.

Original Investigation  FREE
Gretchen A. Brenes, PhD; Suzanne C. Danhauer, PhD; Mary F. Lyles, MD; Patricia E. Hogan, MS; Michael E. Miller, PhD
Includes: Supplemental Content

Importance  Generalized anxiety disorder (GAD) is common in older adults; however, access to treatment may be limited, particularly in rural areas.

Objective  To examine the effects of telephone-delivered cognitive behavioral therapy (CBT) compared with telephone-delivered nondirective supportive therapy (NST) in rural older adults with GAD.

Design, ...

Eric D. Caine, MD

Suicide evokes the image of a lonely, hopeless, deeply distressed person—nearly 80% are men—often influenced by alcohol or drugs, taking their lives following losses or disruptive life experiences. Younger persons’ suicides may be less contemplated but typically just as lonely and disconnected. Older persons, for whom planning is ...

Original Investigation 
Alexander C. Tsai, MD, PhD; Michel Lucas, PhD, RD; Ichiro Kawachi, MD, PhD
Includes: Supplemental Content

Importance  Suicide is one of the top 10 leading causes of mortality among middle-aged women. Most work in the field emphasizes the psychiatric, psychological, or biological determinants of suicide.

Objective  To estimate the association between social integration and suicide.

Design, Setting, and Participants  We used ...

Editorial: Suicide and Social Processes; Eric D. Caine, MD
Comment & Response 
Craig J. Bryan, PsyD, ABPP

To the Editor The study by Reger et al1 published in JAMA Psychiatry reported that deployment history was not associated with suicide death among military personnel who had deployed to Iraq or Afghanistan. Their results converge with several previously published studies2,3 but contradict findings ...

Comment & Response 
Mark A. Reger, PhD; Nancy A. Skopp, PhD; Derek J. Smolenski, PhD, MPH

In Reply We are grateful for Dr Bryan’s careful consideration of our article.1 His analysis was helpful in summarizing and emphasizing some points from our article. It was unclear whether he felt deployment history should not have been used as an exposure variable in our study or ...

The neuropsychiatric impact of World War I, World War II, and the Korean War was described in terms such as shell shock, neurasthenia, psychoneurosis, and battle fatigue. For the Vietnam generation, readjustment problems were initially attributed to alcohol or substance use, followed by growing ...

Original Investigation 
J. Daniel Ragland, PhD; Charan Ranganath, PhD; Michael P. Harms, PhD; Deanna M. Barch, PhD; James M. Gold, PhD; Evan Layher, BA; Tyler A. Lesh, PhD; Angus W. MacDonald III, PhD; Tara A. Niendam, PhD; Joshua Phillips, BA; Steven M. Silverstein, PhD; Andrew P. Yonelinas, PhD; Cameron S. Carter, MD
Includes: Supplemental Content

Importance  Individuals with schizophrenia can encode item-specific information to support familiarity-based recognition but are disproportionately impaired encoding interitem relationships (relational encoding) and recollecting information. The Relational and Item-Specific Encoding (RiSE) paradigm has been used to disentangle these encoding and retrieval processes, which may depend on specific medial ...

Original Investigation 
Charles R. Marmar, MD; William Schlenger, PhD; Clare Henn-Haase, PsyD; Meng Qian, PhD; Emily Purchia, MPH; Meng Li, MA; Nida Corry, PhD; Christianna S. Williams, PhD; Chia-Lin Ho, PhD; Danny Horesh, PhD; Karen-Inge Karstoft, PhD; Arieh Shalev, MD; Richard A. Kulka, PhD
Includes: Supplemental Content

Importance  The long-term course of readjustment problems in military personnel has not been evaluated in a nationally representative sample. The National Vietnam Veterans Longitudinal Study (NVVLS) is a congressionally mandated assessment of Vietnam veterans who underwent previous assessment in the National Vietnam Veterans Readjustment Study (NVVRS).


Editorial: Long-term Impact of War-Zone Military Service; Charles W. Hoge, MD
Neuroscience and Psychiatry 
Martin Lepage, PhD; Colin Hawco, PhD; Michael Bodnar, PhD

This Neuroscience and Psychiatry article discusses the implications of relational memory deficits in schizophrenia and whether they are a reliable cognitive marker for the disease.

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