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 Showing 1-19 of 19 Articles
Original Investigation 
John C. Fortney, PhD; Jeffrey M. Pyne, MD; Timothy A. Kimbrell, MD; Teresa J. Hudson, PharmD; Dean E. Robinson, MD; Ronald Schneider, MD; William M. Moore, PhD; Paul J. Custer, PhD; Kathleen M. Grubbs, PhD; Paula P. Schnurr, PhD
Includes: Supplemental Content

Importance  Posttraumatic stress disorder (PTSD) is prevalent, persistent, and disabling. Although psychotherapy and pharmacotherapy have proven efficacious in randomized clinical trials, geographic barriers impede rural veterans from engaging in these evidence-based treatments.

Objective  To test a telemedicine-based collaborative care model designed to improve engagement in evidence-based ...

Original Investigation 
Tim Hahn, PhD; Tilo Kircher, MD; Benjamin Straube, PhD; Hans-Ulrich Wittchen, PhD ; Carsten Konrad, MD; Andreas Ströhle, MD; André Wittmann, PhD; Bettina Pfleiderer, MD, PhD; Andreas Reif, MD; Volker Arolt, MD; Ulrike Lueken, PhD
Includes: Supplemental Content

Importance  Although neuroimaging research has made substantial progress in identifying the large-scale neural substrate of anxiety disorders, its value for clinical application lags behind expectations. Machine-learning approaches have predictive potential for individual-patient prognostic purposes and might thus aid translational efforts in psychiatric research.

Objective  To predict ...

Original Investigation 
Andy C. Belden, PhD; Deanna M. Barch, PhD; Timothy J. Oakberg, MA; Laura M. April, BA; Michael P. Harms, PhD; Kelly N. Botteron, MD; Joan L. Luby, MD
Includes: Supplemental Content

Importance  This is the first study to date to examine volumetric alterations in the anterior insula (AI) as a potential biomarker for the course of childhood major depressive disorder (MDD).

Objectives  To examine whether children with a history of preschool-onset (PO) MDD show reduced AI volume, ...

Original Investigation 
Ronald C. Kessler, PhD; Christopher H. Warner, MD; Christopher Ivany, MD; Maria V. Petukhova, PhD; Sherri Rose, PhD; Evelyn J. Bromet, PhD; Millard Brown III, MD, MB; Tianxi Cai, ScD; Lisa J. Colpe, PhD, MPH; Kenneth L. Cox, MD, MPH; Carol S. Fullerton, PhD; Stephen E. Gilman, ScD; Michael J. Gruber, MS; Steven G. Heeringa, PhD; Lisa Lewandowski-Romps, PhD; Junlong Li, PhD; Amy M. Millikan-Bell, MD, MPH; James A. Naifeh, PhD; Matthew K. Nock, PhD; Anthony J. Rosellini, PhD; Nancy A. Sampson, BA; Michael Schoenbaum, PhD; Murray B. Stein, MD, MPH; Simon Wessely, PhD; Alan M. Zaslavsky, PhD; Robert J. Ursano, MD; for the Army STARRS Collaborators

Importance  The US Army experienced a sharp increase in soldier suicides beginning in 2004. Administrative data reveal that among those at highest risk are soldiers in the 12 months after inpatient treatment of a psychiatric disorder.

Objective  To develop an actuarial risk algorithm predicting suicide in ...

Original Investigation 
S. Darius Tandon, PhD; Amanda D. Latimore, PhD; Eric Clay, BS; Lois Mitchell, MSW; Margaret Tucker, MSPH; Freya L. Sonenstein, PhD
Includes: Supplemental Content

Importance  Recent estimates indicate that 6.5 million adolescents and young adults in the United States are neither in school nor working. These youth have significant mental health concerns that require intervention.

Objective  To determine whether a mental health intervention, integrated into an employment training program that ...

Original Investigation 
Dimitris N. Kiosses, PhD; Lisa D. Ravdin, PhD; James J. Gross, PhD; Patrick Raue, PhD; Nabil Kotbi, MD; George S. Alexopoulos, MD
Includes: Supplemental Content

Importance  Problem adaptation therapy (PATH) is a treatment for older adults with major depression, cognitive impairment (from mild cognitive deficits to moderate dementia), and disability. Antidepressants have limited efficacy in this population and psychosocial interventions are inadequately investigated.

Objective  To test the efficacy of 12-week PATH ...

Original Investigation  FREE
Deepak K. Sarpal, MD; Delbert G. Robinson, MD; Todd Lencz, PhD; Miklos Argyelan, MD, MSc; Toshikazu Ikuta, PhD; Katherine Karlsgodt, PhD; Juan A. Gallego, MD, MS; John M. Kane, MD; Philip R. Szeszko, PhD; Anil K. Malhotra, MD
Includes: Supplemental Content

Importance  Previous evidence has implicated corticostriatal abnormalities in the pathophysiology of psychosis. Although the striatum is the primary target of all efficacious antipsychotics, the relationship between its functional connectivity and symptomatic reduction remains unknown.

Objective  To explore the longitudinal effect of treatment with second-generation antipsychotics on ...

Original Investigation  FREE
Toshi A. Furukawa, MD, PhD; Stephen Z. Levine, PhD; Shiro Tanaka, PhD; Yair Goldberg, PhD; Myrto Samara, MD; John M. Davis, MD; Andrea Cipriani, MD, PhD; Stefan Leucht, MD
Includes: Supplemental Content

Importance  Antipsychotic drugs constitute the mainstay in the treatment of schizophrenia, and their efficacy is well established in hundreds of randomized clinical trials. However, it is not known whether they are effective or how effective they are across the wide range of baseline symptom severity.

Objective  ...

Original Investigation 
Kate M. Scott, PhD; Ali Obaid Al-Hamzawi, DM, FICMS; Laura H. Andrade, MD, PhD; Guilherme Borges, DrSc; Jose Miguel Caldas-de-Almeida, MD, PhD; Fabian Fiestas, MD, PhD; Oye Gureje, MD, PhD; Chiyi Hu, MD, PhD; Elie G. Karam, MD; Norito Kawakami, MD, DMSc; Sing Lee, MB, BS; Daphna Levinson, PhD; Carmen C. W. Lim, MSc; Fernando Navarro-Mateu, MD, PhD; Michail Okoliyski, PhD; Jose Posada-Villa, MD; Yolanda Torres, DrHC; David R. Williams, PhD; Victoria Zakhozha, MA; Ronald C. Kessler, PhD

Importance  The inverse social gradient in mental disorders is a well-established research finding with important implications for causal models and policy. This research has used traditional objective social status (OSS) measures, such as educational level, income, and occupation. Recently, subjective social status (SSS) measurement has been advocated ...

Original Investigation 
Lynn M. Almli, PhD; Richard Duncan, PhD; Hao Feng, MSPH; Debashis Ghosh, PhD; Elisabeth B. Binder, MD, PhD; Bekh Bradley, PhD; Kerry J. Ressler, MD, PhD; Karen N. Conneely, PhD; Michael P. Epstein, PhD
Includes: Supplemental Content

Importance  Genetic association studies of psychiatric outcomes often consider interactions with environmental exposures and, in particular, apply tests that jointly consider gene and gene-environment interaction effects for analysis. Using a genome-wide association study (GWAS) of posttraumatic stress disorder (PTSD), we report that heteroscedasticity (defined as variability in ...

Original Investigation 
Thomas Vanicek, MD; Marie Spies, MD; Christina Rami-Mark, MSc; Markus Savli, PhD; Anna Höflich, MD; Georg S. Kranz, MSc, PhD; Andreas Hahn, MSc, PhD; Alexandra Kutzelnigg, MD; Tatjana Traub-Weidinger, MD; Markus Mitterhauser, MSc, PhD; Wolfgang Wadsak, MSc, PhD; Marcus Hacker, MD; Nora D. Volkow, MD; Siegfried Kasper, MD; Rupert Lanzenberger, MD

Importance  Attention-deficit/hyperactivity disorder (ADHD) research has long focused on the dopaminergic system’s contribution to pathogenesis, although the results have been inconclusive. However, a case has been made for the involvement of the noradrenergic system, which modulates cognitive processes, such as arousal, working memory, and response inhibition, all ...

Original Investigation 
Richard A. Bryant, PhD; Lucy Kenny, PhD; Amy Joscelyne, PhD; Natasha Rawson, MPsychol; Fiona Maccallum, PhD; Catherine Cahill, MPsychol; Sally Hopwood, MPsychol; Idan Aderka, PhD; Angela Nickerson, PhD

Importance  Prolonged grief disorder (PGD) is a potentially disabling condition that affects approximately 10% of bereaved people. Grief-focused cognitive behavior therapy (CBT) has been shown to be effective in treating PGD. Although treatments for PGD have focused on exposure therapy, much debate remains about whether exposure therapy ...

Original Investigation 
Snehal M. Pinto Pereira, PhD; Marie-Claude Geoffroy, PhD; Christine Power, PhD

Importance  Associations have been documented between physical activity and depressive symptoms, but the direction of this association is unclear.

Objective  To examine whether depressive symptoms are concurrent with physical activity and to examine the direction of the relationship from 23 to 50 years of age.

Design, ...

Original Investigation 
Ole Köhler, MD; Michael E. Benros, PhD; Merete Nordentoft, PhD; Michael E. Farkouh, MD, MSc; Rupa L. Iyengar, MPH; Ole Mors, PhD; Jesper Krogh, MD
Includes: Supplemental Content

Importance  Several studies have reported antidepressant effects of anti-inflammatory treatment; however, the results have been conflicting and detrimental adverse effects may contraindicate the use of anti-inflammatory agents.

Objective  To systematically review the antidepressant and possible adverse effects of anti-inflammatory interventions.

Data Sources  Trials published prior ...

Original Investigation 
Christoph U. Correll, MD; Delbert G. Robinson, MD; Nina R. Schooler, PhD; Mary F. Brunette, MD; Kim T. Mueser, PhD; Robert A. Rosenheck, MD; Patricia Marcy, BSN; Jean Addington, PhD; Sue E. Estroff, PhD; James Robinson, MEd; David L. Penn, PhD; Susan Azrin, PhD; Amy Goldstein, PhD; Joanne Severe, MS; Robert Heinssen, PhD; John M. Kane, MD
Includes: Supplemental Content

Importance  The fact that individuals with schizophrenia have high cardiovascular morbidity and mortality is well established. However, risk status and moderators or mediators in the earliest stages of illness are less clear.

Objective  To assess cardiometabolic risk in first-episode schizophrenia spectrum disorders (FES) and its relationship ...

Original Investigation 
Bret R. Rutherford, MD; Emily Pott, BA; Jane M. Tandler, BA; Melanie M. Wall, PhD; Steven P. Roose, MD; Jeffrey A. Lieberman, MD
Includes: Supplemental Content

Importance  Because increasing placebo response rates decrease drug-placebo differences and increase the number of failed trials, it is imperative to determine what is causing this trend.

Objectives  To investigate the relationship between antipsychotic medication and placebo response by publication year, and to identify associated study design ...

Viewpoint 
Kenneth S. Kendler, MD; Michael C. O'Donovan, MD
This Viewpoint discusses lessons learned from a recent article from the Schizophrenia Working Group of the Psychiatric Genomics Consortium on 108 schizophrenia-associated genetic loci.
Original Investigation 
Martin Gevonden, MSc; Jan Booij, PhD, MD; Wim van den Brink, PhD, MD; Dennis Heijtel, MSc; Jim van Os, PhD, MD; Jean-Paul Selten, PhD, MD
Includes: Supplemental Content

Importance  An increased risk for psychosis is observed in people with hearing impairment. According to the social defeat hypothesis, the long-term experience of exclusion leads to enhanced baseline activity and/or sensitization of the dopamine system and puts the individual at increased risk for psychosis.

Objective  To ...

Original Investigation 
Glenn T. Konopaske, MD; Nicholas Lange, DSc; Joseph T. Coyle, MD; Francine M. Benes, MD, PhD
Includes: Supplemental Content

Importance  Prior studies have demonstrated reduced dendritic spine density in the dorsolateral prefrontal cortex (DLPFC) in schizophrenia. However, it remains unclear how generalizable this finding is in schizophrenia and if it is seen in bipolar disorder, a historically distinct psychiatric condition.

Objective  To assess whether spine ...

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