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 Showing 1-14 of 14 Articles
Original Investigation  FREE
Angela Heck, PhD; Matthias Fastenrath, PhD; David Coynel, PhD; Bianca Auschra, MS; Horst Bickel, PhD; Virginie Freytag, MS; Leo Gschwind, MS; Francina Hartmann, MS; Frank Jessen, MD; Hanna Kaduszkiewicz, MD; Wolfgang Maier, MD; Annette Milnik, MD; Michael Pentzek, PhD; Steffi G. Riedel-Heller, MD; Klara Spalek, PhD; Christian Vogler, PhD; Michael Wagner, PhD; Siegfried Weyerer, PhD; Steffen Wolfsgruber, MS; Dominique J.-F. de Quervain, MD; Andreas Papassotiropoulos, MD
Includes: Supplemental Content

Importance  Human episodic memory performance is linked to the function of specific brain regions, including the hippocampus; declines as a result of increasing age; and is markedly disturbed in Alzheimer disease (AD), an age-associated neurodegenerative disorder that primarily affects the hippocampus. Exploring the molecular underpinnings of human ...

Original Investigation 
Chris H. Miller, BS; J. Paul Hamilton, PhD; Matthew D. Sacchet, ScB; Ian H. Gotlib, PhD
Includes: Supplemental Content

Importance  Despite its high prevalence and morbidity, the underlying neural basis of major depressive disorder (MDD) in youth is not well understood.

Objectives  To identify in youth diagnosed as having MDD the most reliable neural abnormalities reported in existing functional neuroimaging studies and characterize their relations ...

Editorial 
David Goldman, MD

Cannabis is widely used, psychoactive, and addictive. Given the choice, people in several US states and the District of Columbia have voted to legalize it. In the nation’s capital, it is now legal to possess as many as 3 Cannabis sativa plants. Meanwhile, it remains illegal to have ...

Original Investigation 
David Pagliaccio, PhD; Deanna M. Barch, PhD; Ryan Bogdan, PhD; Phillip K. Wood, PhD; Michael T. Lynskey, PhD; Andrew C. Heath, DPhil; Arpana Agrawal, PhD
Includes: Supplemental Content

Importance  Prior neuroimaging studies have suggested that alterations in brain structure may be a consequence of cannabis use. Siblings discordant for cannabis use offer an opportunity to use cross-sectional data to disentangle such causal hypotheses from shared effects of genetics and familial environment on brain structure and ...

Editorial: America’s Cannabis Experiment; David Goldman, MD
Original Investigation 
Leon French, PhD; Courtney Gray, MSc; Gabriel Leonard, PhD; Michel Perron, PhD; G. Bruce Pike, PhD; Louis Richer, PhD; Jean R. Séguin, PhD; Suzanne Veillette, PhD; C. John Evans, PhD; Eric Artiges, MD, PhD; Tobias Banaschewski, MD, PhD; Arun W. L. Bokde, PhD; Uli Bromberg, PhD; Ruediger Bruehl, PhD; Christian Buchel, MD; Anna Cattrell, PhD; Patricia J. Conrod, PhD; Herta Flor, PhD; Vincent Frouin, PhD; Jurgen Gallinat, MD; Hugh Garavan, PhD; Penny Gowland, PhD; Andreas Heinz, MD; Herve Lemaitre, PhD; Jean-Luc Martinot, MD; Frauke Nees, PhD; Dimitri Papadopoulos Orfanos, PhD; Melissa Marie Pangelinan, PhD; Luise Poustka, MD; Marcella Rietschel, MD; Michael N. Smolka, PhD; Henrik Walter, MD; Robert Whelan, PhD; Nic J. Timpson, PhD; Gunter Schumann, MD; George Davey Smith, MD, DSc; Zdenka Pausova, MD; Tomáš Paus, MD, PhD
Includes: Supplemental Content

Importance  Cannabis use during adolescence is known to increase the risk for schizophrenia in men. Sex differences in the dynamics of brain maturation during adolescence may be of particular importance with regard to vulnerability of the male brain to cannabis exposure.

Objective  To evaluate whether the ...

Editorial: America’s Cannabis Experiment; David Goldman, MD
Original Investigation 
Stephen F. Smagula, PhD; Meryl A. Butters, PhD; Stewart J. Anderson, PhD; Eric J. Lenze, MD; Mary Amanda Dew, PhD; Benoit H. Mulsant, MD; Francis E. Lotrich, MD, PhD; Howard Aizenstein, MD, PhD; Charles F. Reynolds III, MD
Includes: Supplemental Content

Importance  More than 50% of older adults with late-life major depressive disorder fail to respond to initial treatment with first-line pharmacological therapy.

Objectives  To assess typical patterns of response to an open-label trial of extended-release venlafaxine hydrochloride (venlafaxine XR) for late-life depression and to evaluate which ...

Comment & Response 
Roberto Lozano, PhD

To the Editor In their article, Maust et al1 concluded that the absolute effect of antipsychotics on mortality in elderly patients with dementia may be higher than previously reported. To assess this, they compared the estimated mortality risk associated with each antipsychotic agent (eg, haloperidol, risperidone, olanzapine, ...

Comment & Response 
Donovan T. Maust, MD, MS; Lon S. Schneider, MD, MS; Helen C. Kales, MD

In Reply Dr Lozano suggests that in our article,1 we failed to take into account the variation in depression prevalence between the various medication user groups and matched nonusers and that our findings were therefore biased.

Viewpoint 
Bronwyn M. Graham, PhD/MPsychol(Clin); Rick Richardson, PhD

This Viewpoint discusses the use of fibroblast growth factor 2 as an adjunct for treating anxiety.

Editorial 
Helena Chmura Kraemer, PhD

Concern about erroneous conclusions of many published research findings has led to the conclusion that most published research findings are wrong.1,2 What can be done about that? In what follows, I will focus on one common source of false findings: adjusting for covariates.

Original Investigation 
Gretchen A. Brenes, PhD; Suzanne C. Danhauer, PhD; Mary F. Lyles, MD; Patricia E. Hogan, MS; Michael E. Miller, PhD
Includes: Supplemental Content

Importance  Generalized anxiety disorder (GAD) is common in older adults; however, access to treatment may be limited, particularly in rural areas.

Objective  To examine the effects of telephone-delivered cognitive behavioral therapy (CBT) compared with telephone-delivered nondirective supportive therapy (NST) in rural older adults with GAD.

Design, ...

Editorial 
Eric D. Caine, MD

Suicide evokes the image of a lonely, hopeless, deeply distressed person—nearly 80% are men—often influenced by alcohol or drugs, taking their lives following losses or disruptive life experiences. Younger persons’ suicides may be less contemplated but typically just as lonely and disconnected. Older persons, for whom planning is ...

Original Investigation 
Alexander C. Tsai, MD, PhD; Michel Lucas, PhD, RD; Ichiro Kawachi, MD, PhD
Includes: Supplemental Content

Importance  Suicide is one of the top 10 leading causes of mortality among middle-aged women. Most work in the field emphasizes the psychiatric, psychological, or biological determinants of suicide.

Objective  To estimate the association between social integration and suicide.

Design, Setting, and Participants  We used ...

Editorial: Suicide and Social Processes; Eric D. Caine, MD

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