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 Showing 1-20 of 32 Articles

The neuropsychiatric impact of World War I, World War II, and the Korean War was described in terms such as shell shock, neurasthenia, psychoneurosis, and battle fatigue. For the Vietnam generation, readjustment problems were initially attributed to alcohol or substance use, followed by growing ...

Original Investigation 
J. Daniel Ragland, PhD; Charan Ranganath, PhD; Michael P. Harms, PhD; Deanna M. Barch, PhD; James M. Gold, PhD; Evan Layher, BA; Tyler A. Lesh, PhD; Angus W. MacDonald III, PhD; Tara A. Niendam, PhD; Joshua Phillips, BA; Steven M. Silverstein, PhD; Andrew P. Yonelinas, PhD; Cameron S. Carter, MD
Includes: Supplemental Content

Importance  Individuals with schizophrenia can encode item-specific information to support familiarity-based recognition but are disproportionately impaired encoding interitem relationships (relational encoding) and recollecting information. The Relational and Item-Specific Encoding (RiSE) paradigm has been used to disentangle these encoding and retrieval processes, which may depend on specific medial ...

Original Investigation  FREE
Charles R. Marmar, MD; William Schlenger, PhD; Clare Henn-Haase, PsyD; Meng Qian, PhD; Emily Purchia, MPH; Meng Li, MA; Nida Corry, PhD; Christianna S. Williams, PhD; Chia-Lin Ho, PhD; Danny Horesh, PhD; Karen-Inge Karstoft, PhD; Arieh Shalev, MD; Richard A. Kulka, PhD
Includes: Supplemental Content

Importance  The long-term course of readjustment problems in military personnel has not been evaluated in a nationally representative sample. The National Vietnam Veterans Longitudinal Study (NVVLS) is a congressionally mandated assessment of Vietnam veterans who underwent previous assessment in the National Vietnam Veterans Readjustment Study (NVVRS).

Objective...

Editorial: Long-term Impact of War-Zone Military Service; Charles W. Hoge, MD
Neuroscience and Psychiatry 
Martin Lepage, PhD; Colin Hawco, PhD; Michael Bodnar, PhD

This Neuroscience and Psychiatry article discusses the implications of relational memory deficits in schizophrenia and whether they are a reliable cognitive marker for the disease.

There is now strong and often replicated evidence from prospective longitudinal studies that psychopathology in childhood and adolescence robustly predicts psychopathology in adulthood.14 This evidence suggests a degree of specificity over time, such as childhood conduct disorder predicting adult antisocial personality, but also a considerable ...

Original Investigation 
Andrew Zalesky, PhD; Christos Pantelis, MD; Vanessa Cropley, PhD; Alex Fornito, PhD; Luca Cocchi, PhD; Harrison McAdams, PhD; Liv Clasen, PhD; Deanna Greenstein, PhD; Judith L. Rapoport, MD; Nitin Gogtay, MD

Importance  Abnormalities in structural brain connectivity have been observed in patients with schizophrenia. Mapping these abnormalities longitudinally and understanding their genetic risk via sibship studies will provide crucial insight into progressive developmental changes associated with schizophrenia.

Objectives  To identify corticocortical connections exhibiting an altered developmental trajectory ...

Original Investigation  FREE
William E. Copeland, PhD; Dieter Wolke, PhD; Lilly Shanahan, PhD; E. Jane Costello, PhD
Includes: Supplemental Content

Importance  Psychiatric problems are among the most common health problems of childhood.

Objective  To test whether these health problems adversely affect adult functioning even if the problems themselves do not persist.

Design, Setting, and Participants  Prospective, population-based study of 1420 participants from 11 predominantly rural ...

Neuroscience and Psychiatry 
Matcheri S. Keshavan, MD; Tomas Paus, MD, PhD

This Neuroscience and Psychiatry article discusses white matter alterations and brain connectivity in schizophrenia.

Original Investigation  FREE
Robert J. Ursano, MD; Ronald C. Kessler, PhD; Murray B. Stein, MD, MPH; James A. Naifeh, PhD; Pablo A. Aliaga, MA; Carol S. Fullerton, PhD; Nancy A. Sampson, BA; Tzu-Cheg Kao, PhD; Lisa J. Colpe, PhD, MPH; Michael Schoenbaum, PhD; Kenneth L. Cox, MD, MPH; Steven G. Heeringa, PhD; for the Army Study to Assess Risk and Resilience in Servicemembers (STARRS) collaborators
Includes: Supplemental Content

Importance  The rate of suicide attempts in the US Army increased sharply during the wars in Afghanistan and Iraq. Research on this important health outcome has been hampered by the lack of integration among Army administrative data systems.

Objective  To identify risk factors for suicide attempts ...

Comment & Response 
Theodore J. Cicero, PhD; Matthew S. Ellis, MPE

In Reply We appreciate the opportunity to comment on the points raised by Ruan et al and Dart et al. Starting with the latter, Dart et al replicated our findings and came to the same conclusion that we did: abuse-deterrent formulations (ADFs) of opioid drugs are quite effective ...

Comment & Response 
Xiulu Ruan, MD; Srinivas Chiravuri, MD; Alan D. Kaye, MD, Ph.D

To the Editor It is with interest that we read the article “Abuse-Deterrent Formulations and the Prescription Opioid Abuse Epidemic in the United States: Lessons Learned From OxyContin” published in JAMA Psychiatry.1 Through their survey study, Cicero and Ellis1 concluded that abuse-deterrent formulations (ADFs) can ...

Comment & Response 
Richard C. Dart, MD, PhD; S. Geoff Severtson, PhD; Jody L. Green, PhD

To the Editor Cicero and Ellis1 reported that 25% to 30% of individuals entering a group of substance abuse treatment centers endorse the reformulated OxyContin as a drug they had abused in the previous 30 days. Although Cicero and Ellis1 reported that the rate of endorsement ...

Editorial 
Christoph U. Correll, MD; Joseph C. Blader, PhD
Original Investigation  FREE
Mark Olfson, MD, MPH; Marissa King, PhD; Michael Schoenbaum, PhD
Includes: Supplemental Content

Importance  Despite concerns about rising treatment of young people with antipsychotic medications, little is known about trends and patterns of their use in the United States.

Objective  To describe antipsychotic prescription patterns among young people in the United States, focusing on age and sex.

Design, Setting, ...

Editorial: Antipsychotic Use in Youth Without Psychosis; Christoph U. Correll, MD; Joseph C. Blader, PhD
Original Investigation 
Ariel Graff-Guerrero, MD, PhD; Tarek K. Rajji, MD; Benoit H. Mulsant, MD, MS; Shinichiro Nakajima, MD, PhD; Fernando Caravaggio, BSc; Takefumi Suzuki, MD, PhD; Hiroyuki Uchida, MD, PhD; Philip Gerretsen, MD, MSW; Wanna Mar, MA; Bruce G. Pollock, MD, PhD; David C. Mamo, MD, MSc
Includes: Supplemental Content

Importance  Patients with late-life schizophrenia (LLS) are highly susceptible to antipsychotic adverse effects. Treatment guidelines endorse lower antipsychotic doses. However, the optimal dose of antipsychotics and associated dopamine D2/3 receptor (D2/3R) occupancies remain largely unexplored in patients with LLS.

Objective  To evaluate effects ...

Editorial 
William T. Carpenter Jr, MD; Robert W. Buchanan, MD

Long-acting injectable (LAI) antipsychotic medications are significantly underused. In light of their documented efficacy for treatment of psychotic symptoms and robust effect on relapse prevention, their relative lack of use is unfortunate. There are several reasons for this therapeutic neglect, including clinical settings where injections are not part ...

Original Investigation 
Kenneth L. Subotnik, PhD; Laurie R. Casaus, MD; Joseph Ventura, PhD; John S. Luo, MD; Gerhard S. Hellemann, PhD; Denise Gretchen-Doorly, PhD; Stephen Marder, MD; Keith H. Nuechterlein, PhD
Includes: Supplemental Content

Importance  Long-acting, injectable, second-generation antipsychotic medication has tremendous potential to bring clinical stability to persons with schizophrenia. However, long-acting medications are rarely used following a first episode of schizophrenia.

Objective  To compare the clinical efficacy of the long-acting injectable formulation of risperidone with the oral formulation ...

Editorial: Long-Acting Antipsychotic Medication for Treating Schizophrenia; William T. Carpenter Jr, MD; Robert W. Buchanan, MD
Original Investigation 
Eileen A. Curran, MPH; Christina Dalman, PhD, MD; Patricia M. Kearney, PhD, MRCPI; Louise C. Kenny, PhD, MRCOG; John F. Cryan, PhD; Timothy G. Dinan, PhD, MD; Ali S. Khashan, PhD
Includes: Supplemental Content

Importance  Because the rates of cesarean section (CS) are increasing worldwide, it is becoming increasingly important to understand the long-term effects that mode of delivery may have on child development.

Objective  To investigate the association between obstetric mode of delivery and autism spectrum disorder (ASD).

Design, ...

Comment & Response 
Matthew L. Goldman, MD, MS; Ravi N. Shah, MD; Carol A. Bernstein, MD

In Reply We agree with Khan and colleagues about the need to implement programs aimed at trainee wellness starting in medical school. Preclinical training offers an excellent opportunity for mandatory sessions to educate students on the issues of depression, suicide, and substance abuse among physicians. Use of screening ...

Comment & Response 
Rida Khan, BS; Jamie S. Lin, MD; Douglas A. Mata, MD, MPH

To the Editor In a JAMA Psychiatry Viewpoint, Goldman and colleagues1 addressed the current lack of concrete programs for the promotion of mental health among medical residents. Highlighting the success of programs implemented by the US Air Force and University of California, San Diego, they put forth ...

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