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 Showing 1-17 of 17 Articles
Nicholas Moore, MD, PhD; Antoine Pariente, MD, PhD; Bernard Bégaud, MD, PhD
In this issue of JAMA Psychiatry, Olfson et al1 report a very comprehensive study of the use of benzodiazepines in the United States. This study confirmed what has been found in several other countries, that benzodiazepines are used predominantly in elderly persons, mostly women, and for long periods of time.2,3 ...
Original Investigation  FREE
Mark Olfson, MD, MPH; Marissa King, PhD; Michael Schoenbaum, PhD
Includes: Supplemental Content

Importance  Although concern exists regarding the rate of benzodiazepine use, especially long-term use by older adults, little information is available concerning patterns of benzodiazepine use in the United States.

Objective  To describe benzodiazepine prescription patterns in the United States focusing on patient age and duration of ...

“The apple doesn’t fall far from the tree.” This maxim presents the intuitive notion that, for reasons related to inherited genes, environment, or most likely both, a child’s phenotype correlates with the parents’ phenotype. In this issue of JAMA Psychiatry, Moreno-De-Luca et al1 quantify the effect size of de novo ...
Original Investigation 
Andres Moreno-De-Luca, MD; David W. Evans, PhD; K. B. Boomer, PhD; Ellen Hanson, PhD; Raphael Bernier, PhD; Robin P. Goin-Kochel, PhD; Scott M. Myers, MD; Thomas D. Challman, MD; Daniel Moreno-De-Luca, MD; Mylissa M. Slane, MS; Abby E. Hare, PhD; Wendy K. Chung, MD; John E. Spiro, PhD; W. Andrew Faucett, MS; Christa L. Martin, PhD; David H. Ledbetter, PhD
Includes: Supplemental Content

Importance  Most disorders caused by copy number variants (CNVs) display significant clinical variability, often referred to as incomplete penetrance and variable expressivity. Genetic and environmental sources of this variability are not well understood.

Objectives  To investigate the contributors to phenotypic variability in probands with CNVs involving ...

Kelly C. Young-Wolff, PhD, MPH; Lori D. Karan, MD; Judith J. Prochaska, PhD, MPH
This Viewpoint discusses the potential health and other impacts of electronic cigarette use in US jails.
H. Richard Lamb, MD
When Lionel Penrose published his study, “Mental Disease and Crime: Outline of a Comparative Study of European Statistics”1 75 years ago, he had no way of knowing that his research would still be the subject of interest, and even controversy, in major psychiatric journals 3 quarters of a century later.2 ...
Original Investigation 
Adrian P. Mundt, MD; Winnie S. Chow, MA, MSc; Margarita Arduino, MD; Hugo Barrionuevo, MD; Rosemarie Fritsch, MD; Nestor Girala, MD; Alberto Minoletti, MD; Flávia Mitkiewicz, MSc; Guillermo Rivera, MD; María Tavares, MD; Stefan Priebe, FRCPsych
Includes: Supplemental Content

Importance  In 1939, English mathematician, geneticist, and psychiatrist Lionel Sharples Penrose hypothesized that the numbers of psychiatric hospital beds and the sizes of prison populations were inversely related; 75 years later, the question arises as to whether the hypothesis applies to recent developments in South America.

Objective  To explore ...

Original Investigation 
Karen M. Abram, PhD; Naomi A. Zwecker, PhD; Leah J. Welty, PhD; Jennifer A. Hershfield, MA; Mina K. Dulcan, MD; Linda A. Teplin, PhD
Includes: Supplemental Content

Importance  Psychiatric disorders and comorbidity are prevalent among incarcerated juveniles. To date, no large-scale study has examined the comorbidity and continuity of psychiatric disorders after youth leave detention.

Objective  To determine the comorbidity and continuity of psychiatric disorders among youth 5 years after detention.

Design, Setting, ...

Original Investigation 
Daniel J. Safer, MD; Thiyagu Rajakannan, PhD; Mehmet Burcu, MS; Julie M. Zito, PhD

Importance  Patterns and trends of subthreshold DSM-IV mental health diagnoses for youth within US community treatment settings merit systematic research.

Objective  To quantify and assess temporal patterns of DSM-IV diagnoses not otherwise specified (NOS) among youth during physician office visits.

Design, Setting, and Participants  We ...

Original Investigation 
John C. Fortney, PhD; Jeffrey M. Pyne, MD; Timothy A. Kimbrell, MD; Teresa J. Hudson, PharmD; Dean E. Robinson, MD; Ronald Schneider, MD; William M. Moore, PhD; Paul J. Custer, PhD; Kathleen M. Grubbs, PhD; Paula P. Schnurr, PhD
Includes: Supplemental Content

Importance  Posttraumatic stress disorder (PTSD) is prevalent, persistent, and disabling. Although psychotherapy and pharmacotherapy have proven efficacious in randomized clinical trials, geographic barriers impede rural veterans from engaging in these evidence-based treatments.

Objective  To test a telemedicine-based collaborative care model designed to improve engagement in evidence-based ...

Original Investigation 
Tim Hahn, PhD; Tilo Kircher, MD; Benjamin Straube, PhD; Hans-Ulrich Wittchen, PhD ; Carsten Konrad, MD; Andreas Ströhle, MD; André Wittmann, PhD; Bettina Pfleiderer, MD, PhD; Andreas Reif, MD; Volker Arolt, MD; Ulrike Lueken, PhD
Includes: Supplemental Content

Importance  Although neuroimaging research has made substantial progress in identifying the large-scale neural substrate of anxiety disorders, its value for clinical application lags behind expectations. Machine-learning approaches have predictive potential for individual-patient prognostic purposes and might thus aid translational efforts in psychiatric research.

Objective  To predict ...

Original Investigation 
Andy C. Belden, PhD; Deanna M. Barch, PhD; Timothy J. Oakberg, MA; Laura M. April, BA; Michael P. Harms, PhD; Kelly N. Botteron, MD; Joan L. Luby, MD
Includes: Supplemental Content

Importance  This is the first study to date to examine volumetric alterations in the anterior insula (AI) as a potential biomarker for the course of childhood major depressive disorder (MDD).

Objectives  To examine whether children with a history of preschool-onset (PO) MDD show reduced AI volume, ...

Original Investigation 
Ronald C. Kessler, PhD; Christopher H. Warner, MD; Christopher Ivany, MD; Maria V. Petukhova, PhD; Sherri Rose, PhD; Evelyn J. Bromet, PhD; Millard Brown III, MD, MB; Tianxi Cai, ScD; Lisa J. Colpe, PhD, MPH; Kenneth L. Cox, MD, MPH; Carol S. Fullerton, PhD; Stephen E. Gilman, ScD; Michael J. Gruber, MS; Steven G. Heeringa, PhD; Lisa Lewandowski-Romps, PhD; Junlong Li, PhD; Amy M. Millikan-Bell, MD, MPH; James A. Naifeh, PhD; Matthew K. Nock, PhD; Anthony J. Rosellini, PhD; Nancy A. Sampson, BA; Michael Schoenbaum, PhD; Murray B. Stein, MD, MPH; Simon Wessely, PhD; Alan M. Zaslavsky, PhD; Robert J. Ursano, MD; for the Army STARRS Collaborators

Importance  The US Army experienced a sharp increase in soldier suicides beginning in 2004. Administrative data reveal that among those at highest risk are soldiers in the 12 months after inpatient treatment of a psychiatric disorder.

Objective  To develop an actuarial risk algorithm predicting suicide in ...

Original Investigation 
S. Darius Tandon, PhD; Amanda D. Latimore, PhD; Eric Clay, BS; Lois Mitchell, MSW; Margaret Tucker, MSPH; Freya L. Sonenstein, PhD
Includes: Supplemental Content

Importance  Recent estimates indicate that 6.5 million adolescents and young adults in the United States are neither in school nor working. These youth have significant mental health concerns that require intervention.

Objective  To determine whether a mental health intervention, integrated into an employment training program that ...

Original Investigation 
Dimitris N. Kiosses, PhD; Lisa D. Ravdin, PhD; James J. Gross, PhD; Patrick Raue, PhD; Nabil Kotbi, MD; George S. Alexopoulos, MD
Includes: Supplemental Content

Importance  Problem adaptation therapy (PATH) is a treatment for older adults with major depression, cognitive impairment (from mild cognitive deficits to moderate dementia), and disability. Antidepressants have limited efficacy in this population and psychosocial interventions are inadequately investigated.

Objective  To test the efficacy of 12-week PATH ...

Original Investigation 
Deepak K. Sarpal, MD; Delbert G. Robinson, MD; Todd Lencz, PhD; Miklos Argyelan, MD, MSc; Toshikazu Ikuta, PhD; Katherine Karlsgodt, PhD; Juan A. Gallego, MD, MS; John M. Kane, MD; Philip R. Szeszko, PhD; Anil K. Malhotra, MD
Includes: Supplemental Content

Importance  Previous evidence has implicated corticostriatal abnormalities in the pathophysiology of psychosis. Although the striatum is the primary target of all efficacious antipsychotics, the relationship between its functional connectivity and symptomatic reduction remains unknown.

Objective  To explore the longitudinal effect of treatment with second-generation antipsychotics on ...

Original Investigation 
Toshi A. Furukawa, MD, PhD; Stephen Z. Levine, PhD; Shiro Tanaka, PhD; Yair Goldberg, PhD; Myrto Samara, MD; John M. Davis, MD; Andrea Cipriani, MD, PhD; Stefan Leucht, MD
Includes: Supplemental Content

Importance  Antipsychotic drugs constitute the mainstay in the treatment of schizophrenia, and their efficacy is well established in hundreds of randomized clinical trials. However, it is not known whether they are effective or how effective they are across the wide range of baseline symptom severity.

Objective  ...

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