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 Showing 1-20 of 20 Articles
Editorial 
Christoph U. Correll, MD; Joseph C. Blader, PhD
Original Investigation  FREE
Mark Olfson, MD, MPH; Marissa King, PhD; Michael Schoenbaum, PhD
Includes: Supplemental Content

Importance  Despite concerns about rising treatment of young people with antipsychotic medications, little is known about trends and patterns of their use in the United States.

Objective  To describe antipsychotic prescription patterns among young people in the United States, focusing on age and sex.

Design, Setting, ...

Editorial: Antipsychotic Use in Youth Without Psychosis; Christoph U. Correll, MD; Joseph C. Blader, PhD
Original Investigation 
Ariel Graff-Guerrero, MD, PhD; Tarek K. Rajji, MD; Benoit H. Mulsant, MD, MS; Shinichiro Nakajima, MD, PhD; Fernando Caravaggio, BSc; Takefumi Suzuki, MD, PhD; Hiroyuki Uchida, MD, PhD; Philip Gerretsen, MD, MSW; Wanna Mar, MA; Bruce G. Pollock, MD, PhD; David C. Mamo, MD, MSc
Includes: Supplemental Content

Importance  Patients with late-life schizophrenia (LLS) are highly susceptible to antipsychotic adverse effects. Treatment guidelines endorse lower antipsychotic doses. However, the optimal dose of antipsychotics and associated dopamine D2/3 receptor (D2/3R) occupancies remain largely unexplored in patients with LLS.

Objective  To evaluate effects ...

Editorial 
William T. Carpenter Jr, MD; Robert W. Buchanan, MD

Long-acting injectable (LAI) antipsychotic medications are significantly underused. In light of their documented efficacy for treatment of psychotic symptoms and robust effect on relapse prevention, their relative lack of use is unfortunate. There are several reasons for this therapeutic neglect, including clinical settings where injections are not part ...

Original Investigation 
Kenneth L. Subotnik, PhD; Laurie R. Casaus, MD; Joseph Ventura, PhD; John S. Luo, MD; Gerhard S. Hellemann, PhD; Denise Gretchen-Doorly, PhD; Stephen Marder, MD; Keith H. Nuechterlein, PhD
Includes: Supplemental Content

Importance  Long-acting, injectable, second-generation antipsychotic medication has tremendous potential to bring clinical stability to persons with schizophrenia. However, long-acting medications are rarely used following a first episode of schizophrenia.

Objective  To compare the clinical efficacy of the long-acting injectable formulation of risperidone with the oral formulation ...

Editorial: Long-Acting Antipsychotic Medication for Treating Schizophrenia; William T. Carpenter Jr, MD; Robert W. Buchanan, MD
Original Investigation 
Eileen A. Curran, MPH; Christina Dalman, PhD, MD; Patricia M. Kearney, PhD, MRCPI; Louise C. Kenny, PhD, MRCOG; John F. Cryan, PhD; Timothy G. Dinan, PhD, MD; Ali S. Khashan, PhD
Includes: Supplemental Content

Importance  Because the rates of cesarean section (CS) are increasing worldwide, it is becoming increasingly important to understand the long-term effects that mode of delivery may have on child development.

Objective  To investigate the association between obstetric mode of delivery and autism spectrum disorder (ASD).

Design, ...

Comment & Response 
Matthew L. Goldman, MD, MS; Ravi N. Shah, MD; Carol A. Bernstein, MD

In Reply We agree with Khan and colleagues about the need to implement programs aimed at trainee wellness starting in medical school. Preclinical training offers an excellent opportunity for mandatory sessions to educate students on the issues of depression, suicide, and substance abuse among physicians. Use of screening ...

Comment & Response 
Rida Khan, BS; Jamie S. Lin, MD; Douglas A. Mata, MD, MPH

To the Editor In a JAMA Psychiatry Viewpoint, Goldman and colleagues1 addressed the current lack of concrete programs for the promotion of mental health among medical residents. Highlighting the success of programs implemented by the US Air Force and University of California, San Diego, they put forth ...

Original Investigation 
Andreas Frick, MSc; Fredrik Åhs, PhD; Jonas Engman, MSc; My Jonasson, MSc; Iman Alaie, MSc; Johannes Björkstrand, MSc; Örjan Frans, PhD; Vanda Faria, PhD; Clas Linnman, PhD; Lieuwe Appel, PhD; Kurt Wahlstedt, MD, PhD; Mark Lubberink, PhD; Mats Fredrikson, PhD, DMSc; Tomas Furmark, PhD
Includes: Supplemental Content

Importance  Serotonin is involved in negative affect, but whether anxiety syndromes, such as social anxiety disorder (SAD), are characterized by an overactive or underactive serotonin system has not been established. Serotonin 1A autoreceptors, which inhibit serotonin synthesis and release, are downregulated in SAD, and serotonin transporter availability ...

Original Investigation 
David Mataix-Cols, PhD; Kayoko Isomura, MD, PhD; Ana Pérez-Vigil, MD; Zheng Chang, PhD; Christian Rück, MD, PhD; K. Johan Larsson, MD; James F. Leckman, MD, PhD; Eva Serlachius, MD, PhD; Henrik Larsson, PhD; Paul Lichtenstein, PhD
Includes: Supplemental Content

Importance  Tic disorders, including Tourette syndrome (TS) and chronic tic disorders (CTDs), are assumed to be strongly familial and heritable. Although gene-searching efforts are well under way, precise estimates of familial risk and heritability are lacking. Previous controlled family studies were small and typically conducted within specialist ...

Original Investigation 
Manabu Kubota, MD, PhD; Neeltje E. M. van Haren, PhD; Sander V. Haijma, MD; Hugo G. Schnack, PhD; Wiepke Cahn, MD, PhD; Hilleke E. Hulshoff Pol, PhD; René S. Kahn, MD, PhD
Includes: Supplemental Content

Importance  Although schizophrenia is characterized by impairments in intelligence and the loss of brain volume, the relationship between changes in IQ and brain measures is not clear.

Objective  To investigate the association between IQ and brain measures in patients with schizophrenia across time.

Design, Setting, and ...

Neuroscience and Psychiatry 
Murray B. Stein, MD, MPH; Anne M. Andrews, PhD

This Neuroscience and Psychiatry article discusses the role in social anxiety of a novel disrupted regulatory sequence in serotonin neurochemistry resulting from overactive serotonin signaling.

Editorial 
Neil D. Woodward, PhD; Carissa J. Cascio, PhD

The idea that serious mental illnesses, such as autism and schizophrenia, result from abnormal connectivity among large-scale brain networks is gaining widespread acceptance. Efforts to test hypotheses of dysconnectivity have historically been hindered by tools with insufficient spatial resolution to investigate human brain connectivity in vivo and an ...

Original Investigation 
Leonardo Cerliani, PhD; Maarten Mennes, PhD; Rajat M. Thomas, PhD; Adriana Di Martino, MD; Marc Thioux, PhD; Christian Keysers, PhD
Includes: Supplemental Content

Importance  Individuals with autism spectrum disorder (ASD) exhibit severe difficulties in social interaction, motor coordination, behavioral flexibility, and atypical sensory processing, with considerable interindividual variability. This heterogeneous set of symptoms recently led to investigating the presence of abnormalities in the interaction across large-scale brain networks. To date, ...

Editorial: Resting-State Functional Connectivity in Psychiatric Disorders; Neil D. Woodward, PhD; Carissa J. Cascio, PhD
Original Investigation 
Shulamite A. Green, PhD; Leanna Hernandez, MA; Nim Tottenham, PhD; Kate Krasileva, BA; Susan Y. Bookheimer, PhD; Mirella Dapretto, PhD
Includes: Supplemental Content

Importance  More than half of youth with autism spectrum disorders (ASDs) have sensory overresponsivity (SOR), an extreme negative reaction to sensory stimuli. However, little is known about the neurobiological basis of SOR, and there are few effective treatments. Understanding whether SOR is due to an initial heightened ...

Original Investigation 
Sohei Kimoto, MD, PhD; Mark M. Zaki; H. Holly Bazmi, MS; David A. Lewis, MD
Includes: Supplemental Content

Importance  In schizophrenia, working memory deficits appear to reflect abnormalities in the generation of gamma oscillations in the dorsolateral prefrontal cortex. The generation of gamma oscillations requires the phasic excitation of inhibitory parvalbumin-containing interneurons. Thus, gamma oscillations depend, in part, on the number of synaptic glutamate receptors ...

Original Investigation  FREE
Bridget F. Grant, PhD; Risë B. Goldstein, PhD, MPH; Tulshi D. Saha, PhD; S. Patricia Chou, PhD; Jeesun Jung, PhD; Haitao Zhang, PhD; Roger P. Pickering, MS; W. June Ruan, MA; Sharon M. Smith, PhD; Boji Huang, MD, PhD; Deborah S. Hasin, PhD
Includes: Supplemental Content

Importance  National epidemiologic information from recently collected data on the new DSM-5 classification of alcohol use disorder (AUD) using a reliable, valid, and uniform data source is needed.

Objective  To present nationally representative findings on the prevalence, correlates, psychiatric comorbidity, associated disability, and treatment of DSM-5...

Special Communication 
Daniel H. Mathalon, PhD, MD; Vikaas S. Sohal, MD, PhD

Neural oscillations are rhythmic fluctuations over time in the activity or excitability of single neurons, local neuronal populations or “assemblies,” and/or multiple regionally distributed neuronal assemblies. Synchronized oscillations among large numbers of neurons are evident in electrocorticographic, electroencephalographic, magnetoencephalographic, and local field potential recordings and are generally understood ...

Original Investigation 
Joris Berwaerts, MD; Yanning Liu, MS; Srihari Gopal, MD, MHS; Isaac Nuamah, PhD; Haiyan Xu, PhD; Adam Savitz, MD, PhD; Danielle Coppola, MD; Alain Schotte, PhD; Bart Remmerie, Chem Eng; Nataliya Maruta, MD, PhD; David W. Hough, MD
Includes: Supplemental Content

Importance  Treatment nonadherence and relapse are common problems in patients with schizophrenia. The long-acting 3-month formulation of paliperidone palmitate, owing to its extended elimination half-life, may offer a valuable therapeutic option for these patients.

Objective  To evaluate the efficacy and safety of the 3-month formulation of ...

Original Investigation 
Yoji Hirano, MD, PhD; Naoya Oribe, MD, PhD; Shigenobu Kanba, MD, PhD; Toshiaki Onitsuka, MD, PhD; Paul G. Nestor, PhD; Kevin M. Spencer, PhD
Includes: Supplemental Content

Importance  A major goal of translational neuroscience is to identify neural circuit abnormalities in neuropsychiatric disorders that can be studied in animal models to facilitate the development of new treatments. Oscillations in the gamma band (30-100 Hz) of the electroencephalogram have received considerable interest as the basic ...

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