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Basic View | Expanded View
 Showing 1-20 of 25 Articles
Viewpoint 
Yuhua Bao, PhD; Yan Tang, MS; Julie Donohue, PhD
This Viewpoint briefly reviews evidence on the range of antidepressant choices needed for depression treatment, examines current antidepressant use patterns in Part D, and assesses how the proposed change would affect the quality of antidepressant treatment in Medicare.
Original Investigation 
Jesse R. Fann, MD, MPH; Charles H. Bombardier, PhD; J. Scott Richards, PhD; Catherine S. Wilson, PsyD; Allen W. Heinemann, PhD; Ann Marie Warren, PhD; Larry Brooks, PhD; Cheryl B. McCullumsmith, MD, PhD; Nancy R. Temkin, PhD; Catherine Warms, PhD; Denise G. Tate, PhD; for the PRISMS Investigators

Importance  Depression is prevalent and associated with negative outcomes in individuals with spinal cord injury (SCI). Antidepressants are used routinely to treat depression, yet no placebo-controlled trials have been published in this population to our knowledge.

Objective  To determine the efficacy and tolerability of venlafaxine hydrochloride ...

Original Investigation 
David P. G. van den Berg, MSc; Paul A. J. M. de Bont, MSc; Berber M. van der Vleugel, MSc; Carlijn de Roos, MSc; Ad de Jongh, PhD; Agnes Van Minnen, PhD; Mark van der Gaag, PhD

Importance  The efficacy of posttraumatic stress disorder (PTSD) treatments in psychosis has not been examined in a randomized clinical trial to our knowledge. Psychosis is an exclusion criterion in most PTSD trials.

Objective  To examine the efficacy and safety of prolonged exposure (PE) therapy and eye ...

Research Letter 
M. Justin Coffey, MD; C. Edward Coffey, MD; Brian K. Ahmedani, PhD
The US Surgeon General and the Institute of Medicine have called for health care systems to help reduce the number of suicides.1,2 However, the few assessments of suicide in such systems have examined specific patient groups rather than the entire population of health plan members.3,4 Here we report, to our ...
Original Investigation 
Jeanne M. Madden, PhD; Alyce S. Adams, PhD; Robert F. LeCates, MA; Dennis Ross-Degnan, ScD; Fang Zhang, PhD; Haiden A. Huskamp, PhD; Daniel M. Gilden, MS; Stephen B. Soumerai, ScD
Includes: Supplemental Content

Importance  More than 1 in 5 disabled people with dual Medicare-Medicaid enrollment have schizophrenia or a bipolar disorder (ie, a serious mental illness). The effect of their transition from Medicaid drug coverage, which varies in generosity across states, to the Medicare Part D drug benefit is unknown. ...

Original Investigation 
Tyler A. Lesh, PhD; Costin Tanase, PhD; Benjamin R. Geib, MS; Tara A. Niendam, PhD; Jong H. Yoon, MD; Michael J. Minzenberg, MD; J. Daniel Ragland, PhD; Marjorie Solomon, PhD; Cameron S. Carter, MD
Includes: Supplemental Content

Importance  Recent data suggest that treatment with antipsychotics is associated with reductions in cortical gray matter in patients with schizophrenia. These findings have led to concerns about the effect of antipsychotic treatment on brain structure and function; however, no studies to date have measured cortical function directly ...

Original Investigation 
Susan L. McElroy, MD; James I. Hudson, MD, ScD; James E. Mitchell, MD; Denise Wilfley, PhD; M. Celeste Ferreira-Cornwell, PhD; Joseph Gao, PhD; Jiannong Wang, PhD; Timothy Whitaker, MD; Jeffrey Jonas, MD; Maria Gasior, MD, PhD

Importance  Binge-eating disorder (BED), a public health problem associated with psychopathological symptoms and obesity and possibly with metabolic syndrome, lacks approved pharmacotherapies.

Objective  To examine the efficacy and safety of lisdexamfetamine dimesylate, a dextroamphetamine prodrug, to treat moderate to severe BED.

Design, Setting, and Participants  ...

Original Investigation 
Yoji Hirano, MD, PhD; Naoya Oribe, MD, PhD; Shigenobu Kanba, MD, PhD; Toshiaki Onitsuka, MD, PhD; Paul G. Nestor, PhD; Kevin M. Spencer, PhD
Includes: Supplemental Content

Importance  A major goal of translational neuroscience is to identify neural circuit abnormalities in neuropsychiatric disorders that can be studied in animal models to facilitate the development of new treatments. Oscillations in the gamma band (30-100 Hz) of the electroencephalogram have received considerable interest as the basic ...

Research Letter 
Lee M. Hampton, MD, MSc; Matthew Daubresse, MHS; Hsien-Yen Chang, PhD; G. Caleb Alexander, MD, MS; Daniel S. Budnitz, MD, MPH
The per capita number of outpatient visits in which an antipsychotic drug was supplied or prescribed increased approximately 660% among children and 380% among adolescents between the mid-1990s and the mid-2000s in the United States,1 prompting concerns about possible inappropriate prescribing. The most recent revisions to the DSM-5 were intended ...
Viewpoint 
Theresa S. Betancourt, ScD, MA
This Viewpoint discusses the effect of the exposure of children to violence. A deeper understanding of the different perspectives on the intergenerational effect of war is central to the work of health care professionals around the world.
Original Investigation 
Kenneth S. Kendler, MD; Jianguang Ji, PhD; Alexis C. Edwards, PhD; Henrik Ohlsson, PhD; Jan Sundquist, MD, PhD; Kristina Sundquist, MD, PhD
Includes: Supplemental Content

Importance  Alcohol use disorder (AUD) runs strongly in families. It is unclear to what extent the cross-generational transmission of AUD results from genetic vs environmental factors.

Objective  To determine to what extent genetic and environmental factors contribute to the risk for AUD.

Design, Setting, and Participants...

Original Investigation 
Andrea L. Roberts, PhD; Jessica C. Agnew-Blais, ScD; Donna Spiegelman, ScD; Laura D. Kubzansky, MPH, PhD; Susan M. Mason, PhD; Sandro Galea, MD; Frank B. Hu, MD; Janet W. Rich-Edwards, ScD; Karestan C. Koenen, PhD
Includes: Supplemental Content

Importance  Posttraumatic stress disorder (PTSD) is a common, debilitating mental disorder that has been associated with type 2 diabetes mellitus (T2D) and its risk factors, including obesity, in cross-sectional studies. If PTSD increases risk of incident T2D, enhanced surveillance in high-risk populations may be warranted.

Objective  ...

Original Investigation 
Joseph A. Simonetti, MD, MPH; Jessica L. Mackelprang, PhD; Ali Rowhani-Rahbar, MD, MPH, PhD; Douglas Zatzick, MD; Frederick P. Rivara, MD, MPH
Includes: Supplemental Content

Importance  Suicide is the second leading cause of death among US adolescents, and in-home firearm access is an independent risk factor for suicide. Given recommendations to limit firearm access by those with mental health risk factors for suicide, we hypothesized that adolescents with such risk factors would ...

Original Investigation 
David A. Brent, MD; Nadine M. Melhem, PhD; Maria Oquendo, MD; Ainsley Burke, PhD; Boris Birmaher, MD; Barbara Stanley, PhD; Candice Biernesser, LSW, MPH; John Keilp, PhD; David Kolko, PhD; Steve Ellis, PhD; Giovanna Porta, MS; Jamie Zelazny, MPH, RN; Satish Iyengar, PhD; J. John Mann, MD
Includes: Supplemental Content

Importance  Suicide attempts are strong predictors of suicide, a leading cause of adolescent mortality. Suicide attempts are highly familial, although the mechanisms of familial transmission are not understood. Better delineation of these mechanisms could help frame potential targets for prevention.

Objective  To examine the mechanisms and ...

Original Investigation 
Gregory M. Sullivan, MD; Maria A. Oquendo, MD; Matthew Milak, MD; Jeffrey M. Miller, MD; Ainsley Burke, PhD; R. Todd Ogden, PhD; Ramin V. Parsey, MD, PhD; J. John Mann, MD

Importance  Serotonergic system dysfunction has been associated with increased lethal suicide attempts and suicide. Dysfunction includes higher binding of serotonin1A autoreceptor in the brainstem raphe of individuals who die by suicide.

Objectives  To determine the relationships between brain serotonin1A binding and suicidal behavior in ...

Editorial 
Odile A. van den Heuvel, MD, PhD
The article by Banks and colleagues1 in this issue of JAMA Psychiatry is an elegant example of how the brain imaging field struggles to translate information on brain mechanisms at the group level to guide clinical practice for individuals. The authors describe the results of a small retrospective study in ...
Original Investigation 
David P. J. Osborn, PhD; Sarah Hardoon, PhD; Rumana Z. Omar, PhD; Richard I. G. Holt, PhD; Michael King, PhD; John Larsen, PhD; Louise Marston, PhD; Richard W. Morris, PhD; Irwin Nazareth, PhD; Kate Walters, PhD; Irene Petersen, PhD
Includes: Supplemental Content

Importance  People with severe mental illness (SMI), including schizophrenia and bipolar disorder, have excess rates of cardiovascular disease (CVD). Risk prediction models validated for the general population may not accurately estimate cardiovascular risk in this group.

Objective  To develop and validate a risk model exclusive to ...

Original Investigation 
Garrett P. Banks, BS; Charles B. Mikell, MD; Brett E. Youngerman, MD; Bryan Henriques, BS; Kathleen M. Kelly, BS; Andrew K. Chan, BS; Diana Herrera; Darin D. Dougherty, MD; Emad N. Eskandar, MD; Sameer A. Sheth, MD, PhD
Includes: Supplemental Content

Importance  Approximately 10% of patients with obsessive-compulsive disorder (OCD) have symptoms that are refractory to pharmacologic and cognitive-behavioral therapies. Neurosurgical interventions can be effective therapeutic options in these patients, but not all individuals respond. The mechanisms underlying this response variability are poorly understood.

Objective  To identify ...

Editorial 
Nicholas Moore, MD, PhD; Antoine Pariente, MD, PhD; Bernard Bégaud, MD, PhD
In this issue of JAMA Psychiatry, Olfson et al1 report a very comprehensive study of the use of benzodiazepines in the United States. This study confirmed what has been found in several other countries, that benzodiazepines are used predominantly in elderly persons, mostly women, and for long periods of time.2,3 ...
Original Investigation 
Mark Olfson, MD, MPH; Marissa King, PhD; Michael Schoenbaum, PhD
Includes: Supplemental Content

Importance  Although concern exists regarding the rate of benzodiazepine use, especially long-term use by older adults, little information is available concerning patterns of benzodiazepine use in the United States.

Objective  To describe benzodiazepine prescription patterns in the United States focusing on patient age and duration of ...

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