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Basic View | Expanded View
 Showing 1-17 of 17 Articles
Viewpoint 
Matthew L. Goldman, MD, MS; Ravi N. Shah, MD; Carol A. Bernstein, MD
This Viewpoint suggests that national organizations should address the mental health of residents and fellows by proposing strategies for comprehensive education, screening, and treatment.
Original Investigation 
Tiziano Pramparo, PhD; Karen Pierce, PhD; Michael V. Lombardo, PhD; Cynthia Carter Barnes, PhD; Steven Marinero, BS; Clelia Ahrens-Barbeau, BS; Sarah S. Murray, PhD; Linda Lopez, MA; Ronghui Xu, PhD; Eric Courchesne, PhD
Includes: Supplemental Content

Importance  The identification of genomic signatures that aid early identification of individuals at risk for autism spectrum disorder (ASD) in the toddler period remains a major challenge because of the genetic and phenotypic heterogeneity of the disorder. Generally, ASD is not diagnosed before the fourth to fifth ...

Original Investigation 
Emma Colvert, PhD; Beata Tick, MSc; Fiona McEwen, PhD; Catherine Stewart, PhD; Sarah R. Curran, MD; Emma Woodhouse, BSc; Nicola Gillan, BSc; Victoria Hallett, PhD; Stephanie Lietz, PhD; Tracy Garnett, DClinPsych; Angelica Ronald, PhD; Robert Plomin, PhD; Frühling Rijsdijk, PhD; Francesca Happé, PhD; Patrick Bolton, MD
Includes: Supplemental Content

Importance  Most evidence to date highlights the importance of genetic influences on the liability to autism and related traits. However, most of these findings are derived from clinically ascertained samples, possibly missing individuals with subtler manifestations, and obtained estimates may not be representative of the population.

Objectives...

Original Investigation 
W. Brad Ruzicka, MD, PhD; Sivan Subburaju, PhD; Francine M. Benes, MD, PhD
Includes: Supplemental Content

Importance  Dysfunction related to γ-aminobutyric acid (GABA)–ergic neurotransmission in the pathophysiology of major psychosis has been well established by the work of multiple groups across several decades, including the widely replicated downregulation of GAD1. Prior gene expression and network analyses within the human hippocampus implicate a ...

Original Investigation 
Amelia Versace, MD; Heather Acuff, BS; Michele A. Bertocci, PhD; Genna Bebko, PhD; Jorge R. C. Almeida, MD, PhD; Susan B. Perlman, PhD; Alexander Leemans, PhD; Claudiu Schirda, PhD; Haris Aslam, BA; Amanda Dwojak, BA; Lisa Bonar, BS; Michael Travis, MD; Mary Kay Gill, RN, MSN; Christine Demeter, MA; Vaibhav A. Diwadkar, PhD; Jeffrey L. Sunshine, MD, PhD; Scott K. Holland, PhD; Robert. A. Kowatch, MD, PhD; Boris Birmaher, MD; David Axelson, MD; Sarah M. Horwitz, PhD; Thomas W. Frazier, PhD; L. Eugene Arnold, MD, MEd; Mary. A Fristad, PhD, ABPP; Eric A. Youngstrom, PhD; Robert L. Findling, MD, MBA; Mary L. Phillips, MD, MD(Cantab)
Includes: Supplemental Content

Importance  Psychiatric disorders in youth characterized by behavioral and emotional dysregulation are often comorbid and difficult to distinguish. An alternative approach to conceptualizing these disorders is to move toward a diagnostic system based on underlying pathophysiologic processes that may cut across conventionally defined diagnoses. Neuroimaging techniques have ...

Original Investigation 
Jacob A. S. Vorstman, MD, PhD; Elemi J. Breetvelt, MD, PhD; Sasja N. Duijff, PhD; Stephan Eliez, MD; Maude Schneider, MSc; Maria Jalbrzikowski, PhD; Marco Armando, MD, PhD; Stefano Vicari, MD, PhD; Vandana Shashi, MD; Stephen R. Hooper, PhD; Eva W. C. Chow, MD, MPH, FRCPC; Wai Lun Alan Fung, MD, ScD, FRCPC; Nancy J. Butcher, MSc; Donald A. Young, PhD, EdD; Donna M. McDonald-McGinn, MS, CGC; Annick Vogels, MD, PhD; Therese van Amelsvoort, MD, PhD; Doron Gothelf, MD; Ronnie Weinberger, MA; Abraham Weizman, MD; Petra W. J. Klaassen, MSc; Sanne Koops, MSc; Wendy R. Kates, PhD; Kevin M. Antshel, PhD; Tony J. Simon, PhD; Opal Y. Ousley, PhD; Ann Swillen, PhD; Raquel E. Gur, MD, PhD; Carrie E. Bearden, PhD; René S. Kahn, MD, PhD; Anne S. Bassett, MD, FRCPC; for the International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome
Includes: Supplemental Content

Importance  Patients with 22q11.2 deletion syndrome (22q11DS) have an elevated (25%) risk of developing schizophrenia. Recent reports have suggested that a subgroup of children with 22q11DS display a substantial decline in cognitive abilities starting at a young age.

Objective  To determine whether early cognitive decline is ...

Original Investigation 
Matthew P. Hyett, BSc, PGDipPsych; Michael J. Breakspear, MBBS, PhD, FRANZCP; Karl J. Friston, MBBS, MRCPsych, FRS; Christine C. Guo, PhD; Gordon B. Parker, MD, PhD, FRANZCP
Includes: Supplemental Content

Importance  Patients with melancholia report a distinct and intrusive dysphoric state during internally generated thought. Melancholia has long been considered to have a strong biological component, but evidence for its specific neurobiological origins is limited. The distinct neurocognitive, psychomotor, and mood disturbances observed in melancholia do, however, ...

Original Investigation 
Heidi A. Browne, BSc; Stefan N. Hansen, MSc; Joseph D. Buxbaum, PhD; Shannon L. Gair, BA; Judith B. Nissen, MD, PhD; Kathrine H. Nikolajsen, MD; Diana E. Schendel, PhD; Abraham Reichenberg, PhD; Erik T. Parner, PhD; Dorothy E. Grice, MD
Includes: Supplemental Content

Importance  Tourette syndrome/chronic tic disorder (TS/CT) and obsessive-compulsive disorder (OCD) overlap in their phenomenological features and often co-occur in affected individuals and families. Understanding how these disorders cluster in families provides important clinical information and is an important step in understanding the causes of these disorders.

Objective...

Research Letter 
Robert H. Pietrzak, PhD, MPH; Lynnette A. Averill, PhD; Chadi G. Abdallah, MD; Alexander Neumeister, MD; John H. Krystal, MD; Ifat Levy, PhD; Ilan Harpaz-Rotem, PhD
The amygdala and hippocampus have been implicated consistently in the pathophysiology of posttraumatic stress disorder (PTSD).1,2 While several studies have observed reduced hippocampal volume in PTSD, studies of amygdala volume and PTSD have been mixed.1- 3
Original Investigation 
Jeffrey F. Scherrer, PhD; Hong Xian, PhD; Wendy S. Slutske, PhD; Seth A. Eisen, MD, MSc; Marc N. Potenza, MD, PhD
Includes: Supplemental Content

Importance  Because of shared characteristics, pathological gambling (PG) has been variously conceptualized as an obsessive-compulsive (OC) spectrum disorder or as an addictive disorder. Prior community-based studies have not systematically determined the association between PG and OC features and whether common genetic factors contribute to both conditions.

Objective...

Original Investigation 
Elizabeth Reisinger Walker, PhD, MPH, MAT; Robin E. McGee, MPH; Benjamin G. Druss, MD, MPH
Includes: Supplemental Content

Importance  Despite the potential importance of understanding excess mortality among people with mental disorders, no comprehensive meta-analyses have been conducted quantifying mortality across mental disorders.

Objective  To conduct a systematic review and meta-analysis of mortality among people with mental disorders and examine differences in mortality risks ...

Original Investigation 
Matthew E. Hirschtritt, MD, MPH; Paul C. Lee, MD, MPH; David L. Pauls, PhD; Yves Dion, MD; Marco A. Grados, MD; Cornelia Illmann, PhD; Robert A. King, MD; Paul Sandor, MD; William M. McMahon, MD; Gholson J. Lyon, MD, PhD; Danielle C. Cath, MD, PhD; Roger Kurlan, MD; Mary M. Robertson, MBChB, MD, DSc(Med), FRCP, FRCPCH, FRCPsych; Lisa Osiecki, BA; Jeremiah M. Scharf, MD, PhD; Carol A. Mathews, MD; for the Tourette Syndrome Association International Consortium for Genetics
Includes: Supplemental Content

Importance  Tourette syndrome (TS) is characterized by high rates of psychiatric comorbidity; however, few studies have fully characterized these comorbidities. Furthermore, most studies have included relatively few participants (<200), and none has examined the ages of highest risk for each TS-associated comorbidity or their etiologic relationship to ...

Research Letter 
Stacey C. Sigmon, PhD
Opioid abuse and dependence are reaching epidemic proportions in the United States, resulting in a staggering number of overdose deaths1 and economic costs that exceed $56 billion annually.2 Medication-assisted therapies, such as buprenorphine (Suboxone) and methadone, represent the most efficacious treatments for opioid dependence. Office-based buprenorphine treatment is especially well ...
Viewpoint 
Arthur Robin Williams, MD, MBE; Mark Olfson, MD, MPH; Marc Galanter, MD
This Viewpoint discusses the differences between patients experiencing denial and those exhibiting lack of insight and addresses interventions that may improve care for patients exhibiting lack of insight.
Original Investigation 
Madeleine Goodkind, PhD; Simon B. Eickhoff, DrMed; Desmond J. Oathes, PhD; Ying Jiang, MD; Andrew Chang, BS; Laura B. Jones-Hagata, MA; Brissa N. Ortega, BS; Yevgeniya V. Zaiko, BA; Erika L. Roach, BA; Mayuresh S. Korgaonkar, PhD; Stuart M. Grieve, DPhil; Isaac Galatzer-Levy, PhD; Peter T. Fox, MD; Amit Etkin, MD, PhD
Includes: Supplemental Content

Importance  Psychiatric diagnoses are currently distinguished based on sets of specific symptoms. However, genetic and clinical analyses find similarities across a wide variety of diagnoses, suggesting that a common neurobiological substrate may exist across mental illness.

Objective  To conduct a meta-analysis of structural neuroimaging studies across ...

Original Investigation 
Mark Slifstein, PhD; Elsmarieke van de Giessen, MD, PhD; Jared Van Snellenberg, PhD; Judy L. Thompson, PhD; Rajesh Narendran, MD; Roberto Gil, MD; Elizabeth Hackett, RT; Ragy Girgis, MD; Najate Ojeil, MS; Holly Moore, PhD; Deepak D’Souza, MD; Robert T. Malison, MD; Yiyun Huang, PhD; Keunpoong Lim, PhD; Nabeel Nabulsi, PhD; Richard E. Carson, PhD; Jeffrey A. Lieberman, MD; Anissa Abi-Dargham, MD
Includes: Supplemental Content

Importance  Multiple lines of evidence suggest a deficit in dopamine release in the prefrontal cortex (PFC) in schizophrenia. Despite the prevalence of the concept of prefrontal cortical hypodopaminergia in schizophrenia, in vivo imaging of dopamine release in the PFC has not been possible until now, when the ...

Original Investigation 
Yoji Hirano, MD, PhD; Naoya Oribe, MD, PhD; Shigenobu Kanba, MD, PhD; Toshiaki Onitsuka, MD, PhD; Paul G. Nestor, PhD; Kevin M. Spencer, PhD
Includes: Supplemental Content

Importance  A major goal of translational neuroscience is to identify neural circuit abnormalities in neuropsychiatric disorders that can be studied in animal models to facilitate the development of new treatments. Oscillations in the gamma band (30-100 Hz) of the electroencephalogram have received considerable interest as the basic ...

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