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Viewpoint | May 22, 2013 
Neurosteroids as Therapeutic Leads in Psychiatry
Charles F. Zorumski, MD; Steven Mennerick, PhD
Considerable progress has been made in understanding how neural circuits contribute to mental processing and psychiatric disorders. This research has highlighted the ...
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JAMA Psychiatry. Published online May 22, 2013. doi:10.1001/jamapsychiatry.2013.245
Original Article | May 22, 2013 
Population-Based, Multigenerational Family Clustering Study of Obsessive-Compulsive Disorder
David Mataix-Cols, PhD; Marcus Boman, BSc; Benedetta Monzani, MSc; Christian Rück, MD; Eva Serlachius, MD; Niklas Långström, MD; Paul Lichtenstein, PhD
Includes: Supplemental Content
ImportanceImportance Controlled family studies have consistently found that obsessive-compulsive disorder (OCD) aggregates in families but have typically relied on samples recruited from ...
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JAMA Psychiatry. Published online May 22, 2013. doi:10.1001/jamapsychiatry.2013.3
Original Article | May 22, 2013 
Noncancer Pain Conditions and Risk of Suicide
Mark A. Ilgen, PhD; Felicia Kleinberg, MSW; Rosalinda V. Ignacio, MS; Amy S. B. Bohnert, PhD; Marcia Valenstein, MD; John F. McCarthy, PhD; Frederic C. Blow, PhD; Ira R. Katz, MD, PhD
ImportanceImportance There are limited data on the extent to which suicide mortality is associated with specific pain conditions.ObjectiveObjective To examine the associations ...
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JAMA Psychiatry. Published online May 22, 2013. doi:10.1001/jamapsychiatry.2013.908
Original Article | May 15, 2013 
Repetitive Traumatic Brain Injury, Psychological Symptoms, and Suicide Risk in a Clinical Sample of Deployed Military Personnel
Craig J. Bryan, PsyD, ABPP; Tracy A. Clemans, PsyD
ImportanceImportance Traumatic brain injury (TBI) is believed to be one factor contributing to rising suicide rates among military personnel and veterans. This ...
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JAMA Psychiatry. Published online May 15, 2013. doi:10.1001/jamapsychiatry.2013.1093
Original Article | May 15, 2013 
Behavioral and Neurophysiological Correlates of Autobiographical Memory Deficits in Patients With Depression and Individuals at High Risk for Depression
Kymberly D. Young, PhD; Patrick S. F. Bellgowan, PhD; Jerzy Bodurka, PhD; Wayne C. Drevets, MD
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ImportanceImportance Individuals with major depressive disorder (MDD) compared with healthy control subjects (HCs) consistently recall fewer specific and more categorical autobiographical memories ...
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JAMA Psychiatry. Published online May 15, 2013. doi:10.1001/jamapsychiatry.2013.1189
Original Article | May 8, 2013 
Rapid Improvement of Acute Schizophrenia Symptoms After Intravenous Sodium Nitroprusside:  A Randomized, Double-blind, Placebo-Controlled Trial
Jaime E. C. Hallak, MD, PhD; Joao Paulo Maia-de-Oliveira, MD; Joao Abrao, MD, PhD; Paulo R. Evora, MD, PhD; Antonio W. Zuardi, MD, PhD; Jose A. S. Crippa, MD, PhD; Paulo Belmonte-de-Abreu, MD; Glen B. Baker, PhD, DSc; Serdar M. Dursun, MD, PhD, FRCPC
ImportanceImportance The treatment of schizophrenia remains a challenge, and the currently available antipsychotic drugs are slow acting and produce a number of ...
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JAMA Psychiatry. Published online May 08, 2013. doi:10.1001/jamapsychiatry.2013.1292
Editorial | May 8, 2013 
Nitric Oxide and Symptom Reduction in Schizophrenia
Joseph T. Coyle, MD
In this issue of the journal, Hallack et al1 report results from a placebo-controlled clinical trial showing that infusion of sodium nitroprusside ...
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JAMA Psychiatry. Published online May 08, 2013. doi:10.1001/jamapsychiatry.2013.210
Original Article | May 8, 2013 
Gestational Influenza and Bipolar Disorder in Adult Offspring
Raveen Parboosing, MBChB, MMed, FCPath(SA)(Viro), MS; Yuanyuan Bao, MS; Ling Shen, PhD; Catherine A. Schaefer, PhD; Alan S. Brown, MD, MPH
ImportanceImportance Gestational influenza has been associated previously with schizophrenia in offspring, but the relationship between this exposure and bipolar disorder (BD) is ...
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JAMA Psychiatry. Published online May 08, 2013. doi:10.1001/jamapsychiatry.2013.896
Original Article | May 1, 2013 
A Prospective Assessment of Reports of Drinking to Self-medicate Mood Symptoms With the Incidence and Persistence of Alcohol Dependence
Rosa M. Crum, MD, MHS; Ramin Mojtabai, MD, PhD; Samuel Lazareck, MD, MSc; James M. Bolton, MD, FRCPC; Jennifer Robinson, MA; Jitender Sareen, MD; Kerry M. Green, PhD; Elizabeth A. Stuart, PhD; Lareina La Flair, MPH; Anika A. H. Alvanzo, MD, MS; Carla L. Storr, ScD
Includes: Supplemental Content
ImportanceImportance Mood disorders and alcohol dependence frequently co-occur. Etiologic theories concerning the comorbidity often focus on drinking to self-medicate or cope with ...
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JAMA Psychiatry. Published online May 01, 2013. doi:10.1001/jamapsychiatry.2013.1098
Editorial | May 1, 2013  FREE
Brain Imaging Biomarkers to Predict Relapse in Alcohol Addiction
Nora D. Volkow, MD; Ruben D. Baler, PhD
Nearly 15 million Americans 12 years of age and older were dependent on or abused alcohol in 2010.1 The high prevalence of ...
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JAMA Psychiatry. Published online May 01, 2013. doi:10.1001/jamapsychiatry.2013.1141
Original Article | May 1, 2013  FREE
Disrupted Ventromedial Prefrontal Function, Alcohol Craving, and Subsequent Relapse Risk
Dongju Seo, PhD; Cheryl M. Lacadie, BA; Keri Tuit, PsyD; Kwang-Ik Hong, MS; R. Todd Constable, PhD; Rajita Sinha, PhD
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ImportanceImportance Alcohol dependence is a chronic relapsing illness; stress, alcohol-related cues, and neutral-relaxing states significantly influence craving and relapse risk. However, neural ...
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JAMA Psychiatry. Published online May 01, 2013. doi:10.1001/jamapsychiatry.2013.762
Original Article | April 24, 2013 
Brain Response to Empathy-Eliciting Scenarios Involving Pain in Incarcerated Individuals With Psychopathy
Jean Decety, PhD; Laurie R. Skelly, PhD; Kent A. Kiehl, PhD
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ImportanceImportance A marked lack of empathy is a hallmark characteristic of individuals with psychopathy. However, neural processes associated with empathic processing have ...
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JAMA Psychiatry. Published online April 24, 2013. doi:10.1001/jamapsychiatry.2013.27
Original Article | April 17, 2013 
Abnormally High Degree Connectivity of the Orbitofrontal Cortex in Obsessive-Compulsive Disorder
Jan C. Beucke, MS; Jorge Sepulcre, MD, PhD; Tanveer Talukdar, MS; Clas Linnman, PhD; Katja Zschenderlein, MS; Tanja Endrass, PhD; Christian Kaufmann, MS; Norbert Kathmann, PhD
Includes: Supplemental Content
ImportanceImportance Neurobiological models of obsessive-compulsive disorder (OCD) predict hyperactivity in brain circuits involving the orbitofrontal cortex and the basal ganglia, but it ...
JAMA Psychiatry. Published online April 17, 2013. doi:10.1001/jamapsychiatry.2013.173
Original Article | April 17, 2013 
Evidence for Multiple Genetic Factors Underlying DSM-IV Criteria for Major Depression
Kenneth S. Kendler, MD; Steven H. Aggen, PhD; Michael C. Neale, PhD
ImportanceImportance We do not know whether the clinical criteria for major depression (MD) reflect a single or multiple dimensions of genetic risk.ObjectiveObjective ...
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JAMA Psychiatry. Published online April 17, 2013. doi:10.1001/jamapsychiatry.2013.751
Original Article | April 17, 2013 
Deficits in Conditioned Fear Extinction in Obsessive-Compulsive Disorder and Neurobiological Changes in the Fear Circuit
Mohammed R. Milad, PhD; Sharon C. Furtak, PhD; Jennifer L. Greenberg, PsyD; Aparna Keshaviah, ScM; Jooyeon J. Im, BA; Martha J. Falkenstein, BS; Michael Jenike, MD; Scott L. Rauch, MD; Sabine Wilhelm, PhD
Includes: Supplemental Content
ImportanceImportance Obsessive-compulsive disorder (OCD) may be characterized by impaired self-regulation and behavioral inhibition. Elevated fear and anxiety are common characteristics of this ...
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JAMA Psychiatry. Published online April 17, 2013. doi:10.1001/jamapsychiatry.2013.914
Editorial | April 10, 2013 
The Potential Value of a Negative Finding:  An Illustrative Example
Kenneth Silverman, PhD; Anthony DeFulio, PhD; Jeannie-Marie Leoutsakos, PhD
Clinical trials with positive findings are more likely to be submitted and published than those with negative findings,1 but negative findings can ...
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JAMA Psychiatry. Published online April 10, 2013. doi:10.1001/jamapsychiatry.2013.1116
Original Article | April 10, 2013 
Genetic Association, Mutation Screening, and Functional Analysis of a Kozak Sequence Variant in the Metabotropic Glutamate Receptor 3 Gene in Bipolar Disorder
Radhika Kandaswamy, MSc, MPhil, PhD; Andrew McQuillin, PhD; Sally I. Sharp, PhD; Alessia Fiorentino, PhD; Adebayo Anjorin, MBchB, MSc, MRCPsych; Robert A. Blizard, MSc, MSc; David Curtis, MBBS, MD, PhD, MRCPsych; Hugh M. D. Gurling, MBBS, MD, MPhil, FRCPsych
Includes: Supplemental Content
ImportanceImportance Genetic markers at the gene encoding the metabotropic glutamate receptor 3 (GRM3) showed allelic association with bipolar disorder.ObjectiveObjective To screen the ...
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JAMA Psychiatry. Published online April 10, 2013. doi:10.1001/jamapsychiatry.2013.38
Original Article | April 10, 2013 
A Multisite, Double-blind, Placebo-Controlled Clinical Trial to Evaluate the Safety and Efficacy of Vigabatrin for Treating Cocaine Dependence
Eugene C. Somoza, MD, PhD; Douglas Winship, BS; Charles W. Gorodetzky, MD, PhD; Daniel Lewis, BS; Domenic A. Ciraulo, MD; Gantt P. Galloway, PharmD; Scott D. Segal, MD; Michael Sheehan, MD; John D. Roache, PhD; Warren K. Bickel, PhD; Donald Jasinski, MD; Donnie W. Watson, PhD; Steven R. Miller, PhD; Peggy Somoza, MS; Theresa Winhusen, PhD
Includes: Supplemental Content
ImportanceImportance Cocaine dependence is a significant public health problem, yet no validated pharmacological treatment exists. The potent γ-aminobutyric acid (GABA)ergic medication vigabatrin ...
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JAMA Psychiatry. Published online April 10, 2013. doi:10.1001/jamapsychiatry.2013.872
Editorial | April 9, 2013 
Psychiatric Genetics:  Are We There Yet?
John Hardy, PhD
The familiality of the major psychiatric disorders, bipolar disease and schizophrenia, has been long recognized and yet, uniquely, the identification of accepted ...
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JAMA Psychiatry. Published online April 09, 2013. doi:10.1001/jamapsychiatry.2013.216
Original Article | April 9, 2013 
A Comprehensive Family-Based Replication Study of Schizophrenia Genes
Karolina A. Aberg, PhD; Youfang Liu, PhD; Jozsef Bukszár, PhD; Joseph L. McClay, PhD; Amit N. Khachane, PhD; Ole A. Andreassen, PhD; Douglas Blackwood, PhD; Aiden Corvin, PhD; Srdjan Djurovic, PhD; Hugh Gurling, PhD; Roel Ophoff, PhD; Carlos N. Pato, MD; Michele T. Pato, MD; Brien Riley, PhD; Todd Webb, PhD; Kenneth Kendler, MD; Mick O’Donovan, PhD; Nick Craddock, PhD; George Kirov, PhD; Mike Owen, PhD; Dan Rujescu, PhD; David St Clair, PhD; Thomas Werge, PhD; Christina M. Hultman, PhD; Lynn E. Delisi, MD; Patrick Sullivan, MD; Edwin J. van den Oord, PhD
Includes: Supplemental Content
ImportanceImportance Schizophrenia (SCZ) is a devastating psychiatric condition. Identifying the specific genetic variants and pathways that increase susceptibility to SCZ is critical ...
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JAMA Psychiatry. Published online April 09, 2013. doi:10.1001/jamapsychiatry.2013.288

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