http://archpsyc.jamanetwork.com/ en-us Wed, 19 Dec 2012 00:00:00 GMT Tue, 01 Jan 2013 00:45:26 GMT Silverchair editor@archpsyc.jamanetwork.com webmaster@archpsyc.jamanetwork.com http://archpsyc.jamanetwork.com/article.aspx?articleID=209841 Sun, 01 Oct 2006 00:00:00 GMT Lieberman JA. <span class="paragraphSection">Despite schizophrenia's longstanding affliction of humankind, effective treatments for this debilitating disorder only became available in the middle of the 20th century. Numerous, now landmark, studies demonstrated incontrovertibly that chlorpromazine, the prototypic antipsychotic, was more effective than nonpharmacologic treatment (eg, placebo, psychotherapy) in alleviating the acute symptoms of schizophrenia and preventing their recurrence. Although many effective antipsychotics have been introduced in the wake of chlorpromazine, the pace of real progress through drug development and innovation has been arduous and slow.</span> 63 10 1069 1072 10.1001/archpsyc.63.10.1069 http://archpsyc.jamanetwork.com/article.aspx?articleID=209841