http://archpsyc.jamanetwork.com/ en-us Mon, 31 Dec 2012 00:00:00 GMT Tue, 01 Jan 2013 00:53:07 GMT Silverchair editor@archpsyc.jamanetwork.com webmaster@archpsyc.jamanetwork.com http://archpsyc.jamanetwork.com/article.aspx?articleID=1383212 Sat, 01 Dec 2012 00:00:00 GMT Lyoo I, Yoon S, Jacobson AM, et al. <span class="paragraphSection"><div class="boxTitle">Context</div>Neural substrates that may be responsible for the high prevalence of depression in type 1 diabetes mellitus (T1DM) have not yet been elucidated.<div class="boxTitle">Objective</div>To investigate neuroanatomic correlates of depression in T1DM.<div class="boxTitle">Design</div>Case-control study using high-resolution brain magnetic resonance images.<div class="boxTitle">Settings</div>Joslin Diabetes Center and McLean Hospital, Massachusetts, and Seoul National University Hospital, South Korea.<div class="boxTitle">Participants</div>A total of 125 patients with T1DM (44 subjects with ≥1 previous depressive episodes [T1DM-depression group] and 81 subjects who had never experienced depressive episodes [T1DM-only group]), 23 subjects without T1DM but with 1 or more previous depressive episodes (depression group), and 38 healthy subjects (control group).<div class="boxTitle">Main Outcome Measures</div>Spatial distributions of cortical thickness for each diagnostic group were compared with the control group using a surface-based approach. Among patients with T1DM, associations between metabolic control measures and cortical thickness deficits were examined.<div class="boxTitle">Results</div>Thickness reduction in the bilateral superior prefrontal cortical regions was observed in the T1DM-depression, T1DM-only, and depression groups relative to the control group at corrected P < .01. Conjunction analyses demonstrated that thickness reductions related to the influence of T1DM and those related to past depressive episode influence were observed primarily in the superior prefrontal cortical region. Long-term glycemic control levels were associated with superior prefrontal cortical deficits in patients with T1DM (β = −0.19, P = .02).<div class="boxTitle">Conclusions</div>This study provides evidence that thickness reduction of prefrontal cortical regions in patients with T1DM, as modified by long-term glycemic control, could contribute to the increased risk for comorbid depression.</span> 69 12 1267 1276 10.1001/archgenpsychiatry.2012.543 http://archpsyc.jamanetwork.com/article.aspx?articleID=1383212