Takayanagi et al examine the lifetime prevalence estimates of mental and physical disorders during midlife to late life using both retrospective and cumulative evaluations. Compton and Lopez provide commentary in a related editorial.
Researchers conducted extensive investigations of hallucinogens in the 1950s and 1960s. By the early 1970s, however, political and cultural pressures forced the cessation of all projects. This investigation reexamines a potentially promising clinical application of hallucinogens in the treatment of anxiety reactive to advanced-stage cancer.
To explore the safety and efficacy of psilocybin in patients with advanced-stage cancer and reactive anxiety.
A double-blind, placebo-controlled study of patients with advanced-stage cancer and anxiety, with subjects acting as their own control, using a moderate dose (0.2 mg/kg) of psilocybin.
A clinical research unit within a large public sector academic medical center.
Twelve adults with advanced-stage cancer and anxiety.
In addition to monitoring safety and subjective experience before and during experimental treatment sessions, follow-up data including results from the Beck Depression Inventory, Profile of Mood States, and State-Trait Anxiety Inventory were collected unblinded for 6 months after treatment.
Safe physiological and psychological responses were documented during treatment sessions. There were no clinically significant adverse events with psilocybin. The State-Trait Anxiety Inventory trait anxiety subscale demonstrated a significant reduction in anxiety at 1 and 3 months after treatment. The Beck Depression Inventory revealed an improvement of mood that reached significance at 6 months; the Profile of Mood States identified mood improvement after treatment with psilocybin that approached but did not reach significance.
This study established the feasibility and safety of administering moderate doses of psilocybin to patients with advanced-stage cancer and anxiety. Some of the data revealed a positive trend toward improved mood and anxiety. These results support the need for more research in this long-neglected field.
clinicaltrials.gov Identifier: NCT00302744
This cohort study examines the risk for developing mental disorders, suicidal behavior, and physical disorders and experiencing adverse social events among people bereaved by spousal suicide.
This population-based case-crossover study uses the Taiwan National Health Insurance Research Database to determine whether the use of antipsychotics is associated with an increased risk of acute respiratory failure in patients with chronic obstructive pulmonary disease.
This nationwide cohort study investigates whether the use of hormonal contraception is positively associated with subsequent use of antidepressants and a diagnosis of depression among women in Denmark.
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